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Cited by 57 publications
(47 citation statements)
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“…In fact, the flavonoids that possessed a catechol moiety had a lower IC 50 than the non-catechol type substances ( Table 1), indicating that the position and number of hydroxyl group on the aromatic ring is important for the determination of aggregation inhibition potency. This result is consistent with previous reports concerning Aβ, 12,13,15,16) but confirmed, in this research, for hIAPP aggregation inhibition.…”
Section: Resultssupporting
confidence: 94%
See 1 more Smart Citation
“…In fact, the flavonoids that possessed a catechol moiety had a lower IC 50 than the non-catechol type substances ( Table 1), indicating that the position and number of hydroxyl group on the aromatic ring is important for the determination of aggregation inhibition potency. This result is consistent with previous reports concerning Aβ, 12,13,15,16) but confirmed, in this research, for hIAPP aggregation inhibition.…”
Section: Resultssupporting
confidence: 94%
“…4) The similarities in Aβ and IAPP oligomers can be used to investigate the prevention of oxidative stress and amyloid aggregation inhibition related to AD and T2D, since potent therapeutic agents such as antioxidants with a catechol moiety, proved to inhibit Aβ aggregation, [12][13][14][15][16] may play a key role inhibiting the aggregation of human IAPP (hIAPP) in case of patients with diabetes.…”
mentioning
confidence: 99%
“…Other reports indicated that total phenylethanoid glycosides of Cistanche species or acteoside could protect the memory deficits or neuronal damage caused by Aβ 25-35 through an antioxidant mechanism and decreasing the ratio of Bax/Bcl2 in vivo or in vitro [6,24]. Recent report further indicated that acteoside inhibited Aβ 1-42 aggregation in a dose-dependent manner by using the thioflavin-T assay [25]. Echinacoside decreased AChE activity in SAMP/8 mice [12].…”
Section: Discussionmentioning
confidence: 99%
“…Compound 121 strongly inhibited the aggregation of 42-mer amyloid β protein in a dose-dependent manner [107]. In another study, compound 121 appeared an inhibitory effect on DHT-induced secretion of both free and total prostate-specific antigen at all tested concentration in an in vitro model of human prostate epithelium [108].…”
Section: Other Pharmacological Effectsmentioning
confidence: 94%