Inhibition of Adenovirus Replication in Vitro by Trifluridine

Antiadenoviral Effect of the α5β1 Integrin Receptor Ligand, GRGDSP Peptide, in Serotypes That Cause Acute Keratoconjunctivitis

“…Among nucleotide analogues, ribavirin [11], trifluridine [12] and cidofovir [13] are reported to be effective in vitro against AdV. Cidofovir and ribavirin are widely used in patients with disseminated adenoviral infection [14, 15].…”

Antiadenoviral Effect of the α5β1 Integrin Receptor Ligand, GRGDSP Peptide, in Serotypes That Cause Acute Keratoconjunctivitis

“…Among nucleotide analogues, ribavirin [11], trifluridine [12] and cidofovir [13] are reported to be effective in vitro against AdV. Cidofovir and ribavirin are widely used in patients with disseminated adenoviral infection [14, 15].…”

Trifluridine, Cidofovir, and Penciclovir in the Treatment of Experimental Herpetic Keratitis

“…Trifluridine has been found to inhibit the growth of adenovirus in tissue culture. 7 Penciclovir(9-[4-hydroxy-3-hydroxymethylbutyl]guanine) (and its betterabsorbed oral prodrug, famciclovir, which is hydrolyzed to penciclovir) is a nucleoside similar to acyclovir. Famciclovir has been approved by the Food and Drug Ad- ministration for use in treating herpes zoster and appears to reduce postzoster pain.…”

Adenoviruses in the immunocompromised host

“…Live, oral entericcoated vaccines against types 4 and 7, which have been effectively used in the military to prevent epidemics of acute respiratory disease (115), have not been approved for use in civilian populations because of the multitude of other serotypes that can cause equally severe illness; no other adenovirus vaccines are planned at present. More recently, purine and pyrimidine base analogs, such as ganciclovir, have been studied as both topical and internal medications and may show some promise (9,11,23,24,41,78,94,116,128,131,138). Otherwise, the best strategies are those of prevention, which have been successfully applied to curtail adenovirus outbreaks in ophthalmologic clinics, hospitals, and nurseries (15,96,129).…”

Antiadenoviral Effect of the α5β1 Integrin Receptor Ligand, GRGDSP Peptide, in Serotypes That Cause Acute Keratoconjunctivitis

“…Among nucleotide analogues, ribavirin [11], trifluridine [12] and cidofovir [13] are reported to be effective in vitro against AdV. Cidofovir and ribavirin are widely used in patients with disseminated adenoviral infection [14, 15].…”

Trifluridine, Cidofovir, and Penciclovir in the Treatment of Experimental Herpetic Keratitis

“…Trifluridine has been found to inhibit the growth of adenovirus in tissue culture. 7 Penciclovir(9-[4-hydroxy-3-hydroxymethylbutyl]guanine) (and its betterabsorbed oral prodrug, famciclovir, which is hydrolyzed to penciclovir) is a nucleoside similar to acyclovir. Famciclovir has been approved by the Food and Drug Ad- ministration for use in treating herpes zoster and appears to reduce postzoster pain.…”

Adenoviruses in the immunocompromised host

“…Live, oral entericcoated vaccines against types 4 and 7, which have been effectively used in the military to prevent epidemics of acute respiratory disease (115), have not been approved for use in civilian populations because of the multitude of other serotypes that can cause equally severe illness; no other adenovirus vaccines are planned at present. More recently, purine and pyrimidine base analogs, such as ganciclovir, have been studied as both topical and internal medications and may show some promise (9,11,23,24,41,78,94,116,128,131,138). Otherwise, the best strategies are those of prevention, which have been successfully applied to curtail adenovirus outbreaks in ophthalmologic clinics, hospitals, and nurseries (15,96,129).…”

Antiadenoviral Effect of the α5β1 Integrin Receptor Ligand, GRGDSP Peptide, in Serotypes That Cause Acute Keratoconjunctivitis

“…Among nucleotide analogues, ribavirin [11], trifluridine [12] and cidofovir [13] are reported to be effective in vitro against AdV. Cidofovir and ribavirin are widely used in patients with disseminated adenoviral infection [14, 15].…”

Trifluridine, Cidofovir, and Penciclovir in the Treatment of Experimental Herpetic Keratitis

“…Trifluridine has been found to inhibit the growth of adenovirus in tissue culture. 7 Penciclovir(9-[4-hydroxy-3-hydroxymethylbutyl]guanine) (and its betterabsorbed oral prodrug, famciclovir, which is hydrolyzed to penciclovir) is a nucleoside similar to acyclovir. Famciclovir has been approved by the Food and Drug Ad- ministration for use in treating herpes zoster and appears to reduce postzoster pain.…”

Adenoviruses in the immunocompromised host

“…Live, oral entericcoated vaccines against types 4 and 7, which have been effectively used in the military to prevent epidemics of acute respiratory disease (115), have not been approved for use in civilian populations because of the multitude of other serotypes that can cause equally severe illness; no other adenovirus vaccines are planned at present. More recently, purine and pyrimidine base analogs, such as ganciclovir, have been studied as both topical and internal medications and may show some promise (9,11,23,24,41,78,94,116,128,131,138). Otherwise, the best strategies are those of prevention, which have been successfully applied to curtail adenovirus outbreaks in ophthalmologic clinics, hospitals, and nurseries (15,96,129).…”