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Cited by 60 publications
(47 citation statements)
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“…These results indicate that kainate receptors are coupled to G proteins of the G i /G o group in rat hippocampal membranes and substantiate the proposal that the presynaptic inhibition of GABA release by kainate receptor activation in the hippocampus (Cunha et al, 1997;Rodríguez-Moreno et al, 1997) involves a metabotropic transduction system (Rodríguez-Moreno and . This G protein coupling of kainate receptors is also a candidate molecular basis for the inhibition of synaptic transmission in the hippocampus (Vignes et al, 1998) or for the hyperpolarization of CA1 neurons caused by a kainate receptor (GLuR5) agonist (Clarke et al, 1997), with both effects being difficult to reconciliate with the activation of ionotropic receptors permeable to cations.…”
Section: Resultssupporting
confidence: 82%
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“…These results indicate that kainate receptors are coupled to G proteins of the G i /G o group in rat hippocampal membranes and substantiate the proposal that the presynaptic inhibition of GABA release by kainate receptor activation in the hippocampus (Cunha et al, 1997;Rodríguez-Moreno et al, 1997) involves a metabotropic transduction system (Rodríguez-Moreno and . This G protein coupling of kainate receptors is also a candidate molecular basis for the inhibition of synaptic transmission in the hippocampus (Vignes et al, 1998) or for the hyperpolarization of CA1 neurons caused by a kainate receptor (GLuR5) agonist (Clarke et al, 1997), with both effects being difficult to reconciliate with the activation of ionotropic receptors permeable to cations.…”
Section: Resultssupporting
confidence: 82%
“…The pellets were then resuspended in the incubation solution containing 50 mM Tris ⅐ HCl and 0.5 mM MgCl 2 (pH 7.4) and maintained at 4°C (incubation buffer). In some experiments, hippocampal synaptosomes were first prepared by sucrose/Percoll isopicnic centrifugations (Cunha et al, 1997), and membranes were prepared after sonication of the synaptosomes.…”
Section: Drugs and Solutions [mentioning
confidence: 99%
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“…The inhibitory synaptic transmission in the hippocampus may be depressed following activation of presynaptic kainate receptors (Clarke et al, 1996), which may be attributed to the inhibition of GABA release, in accordance to the observation made in rat hippocampal synaptosomes (Cunha et al, 1997). Inhibition of GABA release by presynaptic kainate receptors may contribute to the increase in neuronal excitability induced by kainate receptor agonists, eventually causing neuronal toxicity.…”
Section: Presynaptic Kainate Receptors and Regulation Ojneurotransmitmentioning
confidence: 59%
“…Activation of these Ka receptors facilitated transmitter release at such sites as the dorsal root ganglia 347 . Short-term synaptic facilitation is reduced in knockout mice lacking the GluR6, but not the GluR5, Ka receptor subunit suggesting that Ka receptors act as presynaptic autoreceptors o n m o s s y f i b e r t e r m i n a l s t o f a c i l i t a t e s y n a p t i c transmission 348 , but inhibition of GABA release 349 . Also they are involved post synaptically in neurotransmission in some pathways 345,[350][351][352] .…”
Section: ) Kainate Receptorsmentioning
confidence: 99%