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Cited by 5 publications
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“…αSyn is up‐regulated in a subset of neurons in response to chronic OS and is associated with neuroprotection from relatively low levels of OS. Formation of αSyn protofibrils is stimulated by translational modifications that occur under conditions of OS, while its aggregation is inhibited by antioxidants and various proteins with chaperone activity [242]. Many of the above factors demonstrated in Human PD and animal models indicate a multicomponent process in this NDD [see 243] and cell death pathways in PD are caused by many interacting factors [244, 245].…”
Section: Oxidative Injurymentioning
confidence: 99%
“…αSyn is up‐regulated in a subset of neurons in response to chronic OS and is associated with neuroprotection from relatively low levels of OS. Formation of αSyn protofibrils is stimulated by translational modifications that occur under conditions of OS, while its aggregation is inhibited by antioxidants and various proteins with chaperone activity [242]. Many of the above factors demonstrated in Human PD and animal models indicate a multicomponent process in this NDD [see 243] and cell death pathways in PD are caused by many interacting factors [244, 245].…”
Section: Oxidative Injurymentioning
confidence: 99%