Inhibition effect of phenyl compounds from theOryza sativaroots on melanin production in murine B16-F10 melanoma cells

Cho, Jin‐Gyeong; Huh, Jeongran; Jeong, Rak-Hun; Cha, Byeong-Ju; Shrestha, Sabina; Lee, Dong-Geol; Kang, Hee-Cheol; Kim, Jiyoung; Baek, Nam‐In

doi:10.1080/14786419.2014.968155

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…O. sativa has bioactive compounds, including many phenolic compounds as an antioxidant 17 . Five phenyl compounds isolated from the roots of O. sativa L. are vanillin, methyl trans-ferulate, trans-p-coumaric acid methyl ester, N-benzoyltryptamine, and N-(trans-cinnamoyl) tryptamine 40 . Phenols can be divided into two subgroups according to their structure, p-hydroxybenzoic acid derivatives such as gallic, protocatechuic and syringic acids, and hydroxycinnamic derivatives such as caffeic, ferulic, p-coumaric and chlorogenic acids 19 .…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti Aging Assays of Oryza sativa Extracts, Vanillin and Coumaric Acid

Widowati

Fauziah

Herdiman

et al. 2016

JNR

152

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti Aging Assays of Oryza sativa Extracts, Vanillin and Coumaric Acid

Widowati

Fauziah

Herdiman

et al. 2016

JNR

152

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“…The phenolic acid moieties in phenylamide phytoalexins suggest that they likely act as allelochemicals in rice. In addition to UV and pathogen induced accumulation of phenylamide phytoalexins in rice leaves, CinTrp and BenTrp were isolated from rice roots without external stimulus [ 57 ]. A recent study also demonstrated that the phenylamide CinTyr isolated from rice acts as an allelochemical that inhibited root and hypocotyl growth of cress, barnyard grass, and red sprangletop [ 58 ].…”

Section: Phenolic Phytoalexins In Ricementioning

confidence: 99%

Phenolic Phytoalexins in Rice: Biological Functions and Biosynthesis

Cho

Lee

2015

IJMS

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Phytoalexins are inducible secondary metabolites possessing antimicrobial activity against phytopathogens. Rice produces a wide array of phytoalexins in response to pathogen attacks and environmental stresses. With few exceptions, most phytoalexins identified in rice are diterpenoid compounds. Until very recently, flavonoid sakuranetin was the only known phenolic phytoalexin in rice. However, recent studies have shown that phenylamides are involved in defense against pathogen attacks in rice. Phenylamides are amine-conjugated phenolic acids that are induced by pathogen infections and abiotic stresses including ultra violet (UV) radiation in rice. Stress-induced phenylamides, such as N-trans-cinnamoyltryptamine, N-p-coumaroylserotonin and N-cinnamoyltyramine, have been reported to possess antimicrobial activities against rice bacterial and fungal pathogens, an indication of their direct inhibitory roles against invading pathogens. This finding suggests that phenylamides act as phytoalexins in rice and belong to phenolic phytoalexins along with sakuranetin. Phenylamides also have been implicated in cell wall reinforcement for disease resistance and allelopathy of rice. Synthesis of phenolic phytoalexins is stimulated by phytopathogen attacks and abiotic challenges including UV radiation. Accumulating evidence has demonstrated that biosynthetic pathways including the shikimate, phenylpropanoid and arylmonoamine pathways are coordinately activated for phenolic phytoalexin synthesis, and related genes are induced by biotic and abiotic stresses in rice.

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“…[2] Extracts of O. sativa have shown pharmacological effects including antiviral, [3] antitumor, [4] antifungal, [5] antimicrobial, [6] and antimelanogenic effects. [7] Previous phytochemical analysis experiments of O. sativa have reported the presence of bioactive compounds including diterpe-noids, [3,5,8] gibberellins, [3,6] phytosterols, [9] and phenolic compounds. [7] As part of our ongoing efforts to identify significant bioactive compounds in Korean medicinal plants, [10 -17] we have investigated bioactive compounds from the roots of O. sativa and were recently able to identify two new lignans, oryzativols A and B, that reciprocally regulate adipocyte and osteoblast differentiation from the ethanolic extract of O. sativa root.…”

Section: Introductionmentioning

confidence: 99%

“…[7] Previous phytochemical analysis experiments of O. sativa have reported the presence of bioactive compounds including diterpe-noids, [3,5,8] gibberellins, [3,6] phytosterols, [9] and phenolic compounds. [7] As part of our ongoing efforts to identify significant bioactive compounds in Korean medicinal plants, [10 -17] we have investigated bioactive compounds from the roots of O. sativa and were recently able to identify two new lignans, oryzativols A and B, that reciprocally regulate adipocyte and osteoblast differentiation from the ethanolic extract of O. sativa root. [18] Inspired by the discovery of bioactive lignans, we continued to investigate the EtOH extract using a comparative LC/ MS-based analysis approach.…”

Section: Introductionmentioning

confidence: 99%

Biological Evaluation of a New Lignan from the Roots of Rice (Oryza sativa)

Lee

et al. 2018

Chemistry & Biodiversity

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LC/MS-based phytochemical analysis of an EtOH extract of the roots of rice (Oryza sativa; Gramineae), which takes a crucial role in the stable crop population in Asia, resulted in the isolation of a new lignan, oryzativol C (1), as a minor component. The chemical structure of compound 1 was unambiguously confirmed using spectroscopic evidence (including 1D- and 2D-NMR data), HR-ESI-MS, and CD data analysis. Considering the traditional medicinal efficacy of O. sativa and its importance as a food crop, compound 1 was evaluated for effects on breast cancer cell lines (MDA-MB-231) and on glucose-stimulated insulin secretion in an INS-1 pancreatic β-cell line. Compound 1 showed mild cytotoxicity toward the MDA-MB-231. Furthermore, compound 1 stimulated insulin secretion in INS-1 pancreatic β-cells without inducing cytotoxicity. These results indicate that compound 1 is an active ingredient of O. sativa that offers health benefits including inhibition of breast cancer cell proliferation and hyperglycemia control.

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Inhibition effect of phenyl compounds from theOryza sativaroots on melanin production in murine B16-F10 melanoma cells

Cited by 15 publications

References 7 publications

Antioxidant and Anti Aging Assays of <I>Oryza sativa</I> Extracts, Vanillin and Coumaric Acid

Antioxidant and Anti Aging Assays of <I>Oryza sativa</I> Extracts, Vanillin and Coumaric Acid

Phenolic Phytoalexins in Rice: Biological Functions and Biosynthesis

Biological Evaluation of a New Lignan from the Roots of Rice (Oryza sativa)

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