Inhibition by quercetin of the release of density dependent-inhibition of cell growth in RSV-transformed chicken cells

Jullien, M.; Villaudy, J.; Golde, A; Harel, L

doi:10.1016/0309-1651(84)90192-9

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…The identity of the ATPase responsible for steady-state glycolysis in cells that were not inhibited by either ouabain or rutamycin remained undetermined. Similar conclusions were reached by Jullien et al (8) based on studies of ATP turnover with Rous sarcoma virus-transformed cells. They also observed that quercetin inhibited ATP turnover.…”

supporting

confidence: 72%

“…A few were sensitive to oligomycin, suggesting that the mitochondrial ATPase may be activated. Other cell lines were insensitive to both ouabain and oligomycin, but most cell lines were highly sensitive to the bioflavonoid quercetin (7,8). In many cell lines glycolysis was actually stimulated by oligomycin, as would be expected of cells with highly active mitochondria that compete for ADP and Pi required for glycolysis.…”

mentioning

confidence: 96%

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Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes.

Racker¹,

Resnick²,

Feldman³

1985

Proc. Natl. Acad. Sci. U.S.A.

113

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A high rate of aerobic glycolysis was catalyzed by rat-i cells transfected with a ras oncogene (ras cells); rat-i cells and rat-i cells transtected with myc oncogene (myc cells) showed a low rate of glycolysis that was increased after exposure of the cells to type B transforming growth factor (TGF-P). The uptake of radioactive methylaminoisobutyric acid or L-methionine via system A of amino acid transport also was accelerated after exposure of these cells to TGF-p, with the myc cells being most sensitive and the ras cells least sensitive. Methionine was found to be a potent inhibitor of glycolysis in ras cells as well as In rat-i or myc cells that were exposed to TGF-P. We propose a relationship between the product of the ras oncogene (p21) and the protein(s) induced by exposure to TGF-,B.In a landmark paper (1) We have observed (9) that normal rat kidney NRK-49F cells exhibited on exposure to type 3 transforming growth factor (TGF-,B) an increase in the rate of glycolysis and in the uptake of methylaminoisobutyrate (MeAIB), a specific substrate of system A of amino acid transport (10). Independently, Inman and Colowick showed that glucose uptake was stimulated by TGF-/3 in 3T3 cells (11). We also have reported (9) that glycolysis in NRK-49F cells that had been exposed to TGF-P was markedly inhibited by 25 mM methionine, a substrate for system A of amino acid transport, whereas little or no inhibition was noted in the controls that were not exposed to TGF-f3. Examination of various established transformed cell lines revealed that in all of them glycolysis was sensitive to methionine, whereas several nontransformed cell lines showed no or moderate inhibition (unpublished data). Although there were differences between cell lines with respect to the time of exposure to methionine (2-16 hr) required to give rise to an inhibition of 50% or more, thus far no exception has been observed among 10 transformed cell lines grown in tissue culture that were tested. However, glycolysis in suspended EAT cells harvested from infected mice was not inhibited by methionine under the conditions tested. Yet, EAT cells grown in tissue culture were among the most sensitive cell lines, showing a significant inhibition after only 30 min exposure to 10 mM methionine. Removal of methionine from the medium resulted in a complete reversal of the inhibition within 2 hr (unpublished data). The capacity to inhibit glycolysis was shared by other substrates transported via system A, including MeAIB, a synthetic compound that is not metabolized.In view of the fact that methionine inhibits glycolysis in transformed cell lines, we explored the effect of this amino acid and of TGF-,B on rat-1 cells and rat-1 variants transfected with ras or myc oncogenes. We describe in this paper some profound differences in glycolysis, MeAIB uptake, and response to TGF-/3 that we observed between these cell lines. MATERIALS AND METHODSThe rat-i, myc (R1-CMYC), and ras (R1-EJ2) cells were obtained from R. Weinberg. They were grown in Falcon dishes Abbrevia...

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supporting

confidence: 72%

mentioning

confidence: 96%

Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes.

Racker¹,

Resnick²,

Feldman³

1985

Proc. Natl. Acad. Sci. U.S.A.

113

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“…Quercetin has been shown to inhibit DNA, RNA, and protein synthesis in NY68-infected chick embryo fibroblast (Jullien et al, 1984), 12-O-tetradecanyl-13 phorbol acetate-induced ODC activity in mouse skin. This suggests that Emblica officinalis methanolic fruit extract potentially inhibits polyamine biosynthesis and consequently the rate of DNA synthesis at both the doses.…”

Section: Discussionmentioning

confidence: 99%

Emblica officinalis and hepatocarcinogenesis: A chemopreventive study in Wistar rats

Sultana

Ahmed

Jahangir

2008

Journal of Ethnopharmacology

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“…По-видимому, ýто в значительной степени обусловлено ингибирующим влиянием данных полифенолов на цепь биохимических событий, связанных с клеточным ростом [9]. Так, еще в ранних исследованиях было показано, что кверцетин подавлял аýробный гликолиз в опухолевых клетках, а также ингибировал белковый синтез в клеточных культурах ряда опухолей и повышал в ýтих клетках уровень циклического аденозинмонофосфата (АМФ) [1,41,42]. В ýтом контексте отметим роль активируемой 5΄АМФ протеинкиназы АМФК (AMPK), контролирующей ýнергетический баланс клетки.…”

Section: Conflict Of Interestunclassified

Antitumor activity of flavonoids

Зверев

2019

Bûll. sib. med.

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This review of the literature is devoted to the consideration of mechanisms of the antitumor effect of flavonoids. The anticanceromatous effect of flavonoids is discussed in the context of their impact on the main stages of development of malignant tumor cells. At the same time, the influence of flavonoids on the activity of protein kinases, metalloproteinases, apoptosis, angiogenesis and the cell cycle of tumor cells is considered in detail.

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Inhibition by quercetin of the release of density dependent-inhibition of cell growth in RSV-transformed chicken cells

Cited by 8 publications

References 22 publications

Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes.

Glycolysis and methylaminoisobutyrate uptake in rat-1 cells transfected with ras or myc oncogenes.

Emblica officinalis and hepatocarcinogenesis: A chemopreventive study in Wistar rats

Antitumor activity of flavonoids

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