Inhibiting Methicillin-Resistant <i>Staphylococcus aureus</i> by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery

Zhang, Yuxin; Ma, Wenjuan; Zhu, Ying; Shi, Sirong; Li, Qianshun; Mao, Chenchen; Zhao, Dan; Zhan, Yanhu; Shi, Jiye; Li, Wei; Wang, Lihua; Chen, Fan; Lin, Yunfeng

doi:10.1021/acs.nanolett.8b02166

Cited by 112 publications

(105 citation statements)

References 55 publications

(137 reference statements)

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“…Recently, DNA nanotechnology has been developed and employed in a variety of fields owing to the extensive biological functions of DNA nanostructures . Tetrahedral framework nucleic acids (tFNAs) are synthesized by four isometric single‐stranded DNAs through a simple, rapid, and reliable process, which have been identified as 3D DNA nanostructures with a stable structure and superior mechanical properties .…”

Section: Introductionmentioning

confidence: 99%

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

Liu

Zhang

et al. 2019

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Poor post‐traumatic wound healing can affect the normal function of damaged tissues and organs. For example, poor healing of corneal epithelial injuries may lead to permanent visual impairment. It is of great importance to find a therapeutic way to promote wound closure. Tetrahedral framework nucleic acids (tFNAs) are new promising nanomaterials, which can affect the biological behavior of cells. In the experiment, corneal wound healing is used as an example to explore the effect of tFNAs on wound healing. Results show that the proliferation and migration of human corneal epithelial cells are enhanced by exposure to tFNAs in vitro, possibly relevant to the activation of P38 and ERK1/2 signaling pathway. An animal model of corneal alkali burn is established to further identify the facilitation effect of tFNAs on corneal wound healing in vivo. Clinical evaluations and histological analyses show that tFNAs can improve the corneal transparency and accelerate the re‐epithelialization of wounds. Both in vitro and in vivo experiments show that tFNAs can play a positive role in corneal epithelial wound healing.

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Section: Introductionmentioning

confidence: 99%

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

Liu

Zhang

et al. 2019

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“…Peptide nucleic acid (PNA) can specifically hybridize with complementary DNA or RNA and resulting in the inhibition of gene expression. In 2018, Zhang and coworkers reported PNA delivery using TDN as a carrier in methicillin‐resistant Staphylococcus aureus 65 . The ftsZ‐asPNA delivered by TDN effectively targeted the ftsZ gene, which is involved in bacterial cell division, resulting in bacterial growth reduction in a concentration‐dependent manner.…”

Section: Applications As Delivery Vehicles In Cancer Therapymentioning

confidence: 99%

Tetrahedral DNA nanostructures as drug delivery and bioimaging platforms in cancer therapy

2020

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Structural DNA nanotechnology enables DNA to be used as nanomaterials for novel nanostructure construction with unprecedented functionalities. Artificial DNA nanostructures can be designed and generated with precisely controlled features, resulting in its utility in bionanotechnological and biomedical applications. A tetrahedral DNA nanostructure (TDN), the most popular DNA nanostructure, with high stability and simple synthesis procedure, is a promising candidate as nanocarriers in drug delivery and bioimaging platforms, particularly in precision medicine as well as diagnosis for cancer therapy. Recent evidence collectively indicated that TDN successfully enhanced cancer therapeutic efficiency both in vitro and in vivo. Here, we summarize the development of TDN and highlight various aspects of TDN applications in cancer therapy based on previous reports, including anticancer drug loading, photodynamic therapy, therapeutic oligonucleotides, bioimaging platforms, and other molecules and discuss a perspective in opportunities and challenges for future TDN‐based nanomedicine.

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“…Among these, the use of non-viral carriers, such as cell penetrating peptides, has received greater attention due to their minimal toxicity, low levels of immunogenicity, ease and flexibility of assembly [123]. Nevertheless, poor specificity to bacteria cells, protease sensitivity and resistance in cells linked to encoding translocating proteins such as SbmA has been reported [124][125][126]. Nucleic acid hybrid systems can be exploited as alternative vectors to promote uptake of antibacterial agents without detrimental effects.…”

Section: Nucleic Acid Hybrids With Enhanced Cellular Uptakementioning

confidence: 99%

Nucleic Acid Hybrids as Advanced Antibacterial Nanocarriers

Obuobi

Škalko‐Basnet

2020

Pharmaceutics

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Conventional antibiotic therapy is often challenged by poor drug penetration/accumulation at infection sites and poses a significant burden to public health. Effective strategies to enhance the therapeutic efficacy of our existing arsenal include the use of nanoparticulate delivery platforms to improve drug targeting and minimize adverse effects. However, these nanocarriers are often challenged by poor loading efficiency, rapid release and inefficient targeting. Nucleic acid hybrid nanocarriers are nucleic acid nanosystems complexed or functionalized with organic or inorganic materials. Despite their immense potential in antimicrobial therapy, they are seldom utilized against pathogenic bacteria. With the emergence of antimicrobial resistance and the associated complex interplay of factors involved in antibiotic resistance, nucleic acid hybrids represent a unique opportunity to deliver antimicrobials against resistant pathogens and to target specific genes that control virulence or resistance. This review provides an unbiased overview on fabricating strategies for nucleic acid hybrids and addresses the challenges of pristine oligonucleotide nanocarriers. We report recent applications to enhance pathogen targeting, binding and control drug release. As multifunctional next-generational antimicrobials, the challenges and prospect of these nanocarriers are included.

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Inhibiting Methicillin-Resistant Staphylococcus aureus by Tetrahedral DNA Nanostructure-Enabled Antisense Peptide Nucleic Acid Delivery

Cited by 112 publications

References 55 publications

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

Tetrahedral Framework Nucleic Acids Promote Corneal Epithelial Wound Healing in Vitro and in Vivo

Tetrahedral DNA nanostructures as drug delivery and bioimaging platforms in cancer therapy

Nucleic Acid Hybrids as Advanced Antibacterial Nanocarriers

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