Inherited patterned lentiginosis in blacks

O'Neill, J. F.

doi:10.1001/archderm.125.9.1231

Cited by 9 publications

(5 citation statements)

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“…2b) [51, 59, 60, 61]. Most of these lentiginosis syndromes have complex associated systemic anomalies such as myxomas, cardiac and endocrine disorders, although isolated inherited generalized lentiginosis may occur [51, 55, 62, 63, 64]. Linear and whorled nevoid hypermelanosis may produce hyperpigmented, reticulate spots along the lines of Blaschko on the neck and the trunk [65].…”

Section: Reticulate Flexural Pigmentary Disorders (Mim 179850) and Lmentioning

confidence: 99%

Genodermatosis with Reticulate, Patchy and Mottled Pigmentation of the Neck – A Clue to Rare Dermatologic Disorders

Itin

Lautenschläger

1998

Dermatology

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Reticulate pigmentation of the neck is a common finding in numerous genodermatoses and acquired diseases. As the neck is readily accessible to medical inspection, it may serve as a diagnostic window for various dermatoses. Several entities out of the spectrum of ectodermal dysplasia present with reticulate or mottled pigmentation on the upper trunk and neck. The most impressive genodermatoses with punctate and reticulate pigmentation affecting the neck are the Naegeli-Franceschetti-Jadassohn syndrome, dermatopathia pigmentosa reticularis and dyskeratosis congenita. Reticulate pigmented anomaly of the flexures and lentiginosis, disorders of cornification and related entities are further genodermatoses which may involve the neck. In our review we have integrated inherited dermatoses which do not obligatorily affect the neck but have been well documented to do so. Our work should give the clinician a checklist on genodermatoses which may produce reticulate and mottled pigmentation on the neck.

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Section: Reticulate Flexural Pigmentary Disorders (Mim 179850) and Lmentioning

confidence: 99%

Genodermatosis with Reticulate, Patchy and Mottled Pigmentation of the Neck – A Clue to Rare Dermatologic Disorders

Itin

Lautenschläger

1998

Dermatology

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“…5,11 Specific genetic defects are involved in the pathogenesis of melanotic macules as certain familial lentiginoses 56 can exhibit volar melanotic macules such as Peutz-Jegher syndrome, Leopard syndrome, and Carney syndrome (also known as Lentigines, Atrial myxomas, Mucocutaneous myxomas, and Blue nevi (LAMB) or Nevi, Atrial myxoma, Myxoid neurofibroma, and Endocrine disorders/Ephelides (NAME) syndrome). [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] In the familial setting, volar macules are acquired during childhood and found commonly on the fingers as opposed to idiopathic cases, which affect middle-aged and older adults and are found more commonly on the soles and palms. The prevalence of volar macules in patients with familial lentiginoses ranges from 5% in Carney syndrome to approximately 50% in PeutzJegher syndrome.…”

Section: Discussionmentioning

confidence: 99%

Volar Melanotic Macules in a Gardener: A Case Report and Review of the Literature

Blossom

Altmayer²,

Jones³

et al. 2008

The American Journal of Dermatopathology

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Volar melanotic macules are asymptomatic, tan-brown to brownish-black macules found on the palms, fingers, soles, and/or toes of dark-skinned individuals and are infrequently reported in light-skinned individuals. Herein, we report the acquisition of multiple, brownish-black volar digital macules in a 63-year-old white woman and avid gardener that were noted after the onset of pruritic, chronic hand dermatitis over a 10-month period. She was healthy without any medical conditions or medications. No family history of intestinal polyposis or mucosal melanosis existed. At presentation, she had less than 20 brownish-black, 2- to 10-mm irregular macules over the volar aspect of the thumbs and index fingers, left greater than right hand, associated with erythema, scale, and a negative potassium hydroxide examination. In addition, she had melanotic macules of her lips, buccal mucosa, and conjuctiva. No nail or anogenital macules were found. Biopsy demonstrated a region of epidermal hyperplasia, hyperkeratosis, and interface dermatitis associated with melanophages and sparse lymphocytic infiltrate. Melanin staining revealed diffuse pan-epidermal hypermelanization, dermal melanin, and dendritic melanocytes, which expressed HMB-45. After 1-year follow-up and treatment with topical corticosteroid, the volar macules have faded to tan brown. Based on the location, avocation, and coexisting mucosal melanotic macules, an irritant phytodermatitis with postinflammatory hyperpigmentation was diagnosed in the setting of Laugier-Hunziker syndrome-a disorder denoted by macular hyperpigmentation of nail, volar, and/or mucosal surfaces in healthy adults. Volar melanotic macules can also complicate 5-flourouracil therapy, tinea pedis, and other inflammatory disorders; be associated with acral melanomas; or represent a cutaneous manifestation of systemic disease such as Addison disease, Peutz-Jegher syndrome, Leopard syndrome, Carney syndrome, AIDS, and neurofibromatosis.

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“…Patterned lentiginosis was first reported in 1989 by O’Neil et al, who described 10 African-American patients with autosomal dominant transmission of lentigines distributed on the face, lips, extremity, buttock, and palms and soles. None of the patients had lesions of the oral mucosa or internal organ system abnormalities 56 . A separate syndrome, centrofacial neurodysraphic lentiginosis, consisting of facial lentigines associated with mental retardation and autosomal dominant inheritance has also been described.…”

Section: Laugier-hunziker Syndrome (Lhs)mentioning

confidence: 98%

“…Two separate syndromes, patterned lentiginosis and centrofacial neurodysraphic lentiginosis, are both benign lentiginoses conditions that are inherited in an autosomal dominant manner without systemic involvement 56–58 . Patterned lentiginosis was first reported in 1989 by O’Neil et al, who described 10 African-American patients with autosomal dominant transmission of lentigines distributed on the face, lips, extremity, buttock, and palms and soles.…”

Section: Laugier-hunziker Syndrome (Lhs)mentioning

confidence: 99%

The differential diagnosis of familial lentiginosis syndromes

Lodish

Stratakis

2011

Familial Cancer

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Cutaneous markers of systemic disease are vital for clinicians to recognize. This chapter outlines familial lentiginosis syndromes that include Peutz-Jeghers syndrome, Carney Complex, the PTEN hamartomatous syndromes, and LEOPARD/Noonan syndrome. The inheritance of these syndromes is autosomal dominant; they also share characteristic skin findings that offer a clue to their recognition and treatment. We will discuss the clinical presentation of these disorders, with a focus on the dermatological manifestations, and will provide an update on the molecular mechanisms involved. Recognition of cutaneous markers associated with these rare familial cancer syndromes provides the opportunity to pursue early surveillance for malignancies, as well as genetic counseling.

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Inherited patterned lentiginosis in blacks

Cited by 9 publications

References 0 publications

Genodermatosis with Reticulate, Patchy and Mottled Pigmentation of the Neck – A Clue to Rare Dermatologic Disorders

Genodermatosis with Reticulate, Patchy and Mottled Pigmentation of the Neck – A Clue to Rare Dermatologic Disorders

Volar Melanotic Macules in a Gardener: A Case Report and Review of the Literature

The differential diagnosis of familial lentiginosis syndromes

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