Inherited patterned lentiginosis in blacks

Volar Melanotic Macules in a Gardener: A Case Report and Review of the Literature

“…5,11 Specific genetic defects are involved in the pathogenesis of melanotic macules as certain familial lentiginoses 56 can exhibit volar melanotic macules such as Peutz-Jegher syndrome, Leopard syndrome, and Carney syndrome (also known as Lentigines, Atrial myxomas, Mucocutaneous myxomas, and Blue nevi (LAMB) or Nevi, Atrial myxoma, Myxoid neurofibroma, and Endocrine disorders/Ephelides (NAME) syndrome). [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] In the familial setting, volar macules are acquired during childhood and found commonly on the fingers as opposed to idiopathic cases, which affect middle-aged and older adults and are found more commonly on the soles and palms. The prevalence of volar macules in patients with familial lentiginoses ranges from 5% in Carney syndrome to approximately 50% in PeutzJegher syndrome.…”

The differential diagnosis of familial lentiginosis syndromes

“…Patterned lentiginosis was first reported in 1989 by O’Neil et al, who described 10 African-American patients with autosomal dominant transmission of lentigines distributed on the face, lips, extremity, buttock, and palms and soles. None of the patients had lesions of the oral mucosa or internal organ system abnormalities 56 . A separate syndrome, centrofacial neurodysraphic lentiginosis, consisting of facial lentigines associated with mental retardation and autosomal dominant inheritance has also been described.…”

“…Two separate syndromes, patterned lentiginosis and centrofacial neurodysraphic lentiginosis, are both benign lentiginoses conditions that are inherited in an autosomal dominant manner without systemic involvement 56–58 . Patterned lentiginosis was first reported in 1989 by O’Neil et al, who described 10 African-American patients with autosomal dominant transmission of lentigines distributed on the face, lips, extremity, buttock, and palms and soles.…”

Genodermatosis with Reticulate, Patchy and Mottled Pigmentation of the Neck – A Clue to Rare Dermatologic Disorders

“…2b) [51, 59, 60, 61]. Most of these lentiginosis syndromes have complex associated systemic anomalies such as myxomas, cardiac and endocrine disorders, although isolated inherited generalized lentiginosis may occur [51, 55, 62, 63, 64]. Linear and whorled nevoid hypermelanosis may produce hyperpigmented, reticulate spots along the lines of Blaschko on the neck and the trunk [65].…”