Inheritance and heritability of deltamethrin resistance under laboratory conditions of Triatoma infestans from Bolivia

Gomez, Marinely Bustamante; Pessoa, Grasielle D’Avila Caldas; Rosa, Aline Cristine Luiz; Echeverria, Jorge Espinoza; Diotaiuti, Liléia

doi:10.1186/s13071-015-1211-9

Cited by 11 publications

(3 citation statements)

References 40 publications

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“…To provide quantitative studies about the evolution of resistance in triatomines now requires such integrative fitness measures to be calculated for resistant and susceptible individuals in both treated and nontreated conditions as the evolution of resistance usually involves some form of spatially heterogeneous or temporally variable selection with a selective disadvantage of resistant individuals in nontreated environment. Triatomines are typically exposed to lethal doses inside domiciles and sublethal doses in peridomiciles (Bustamante Gomez, Caldas Pessoa, Luiz Rosa, Espinoza Echeverria, & Gonçalves Diotaiuti, ; Fronza, Toloza, Picollo, Spillmann, & Mougabure‐Cueto, ). According to existing models, sublethal doses are likely to limit the evolution of resistance as selective pressures are then relaxed on earlier life stages and mostly affect the older and more infected vector individuals (Read, Lynch, & Thomas, ).…”

Section: Triatomine Life‐history Evolution and Vector Control Challengesmentioning

confidence: 99%

Evolutionary ecology of Chagas disease; what do we know and what do we need?

Flores-Ferrer

Marcou

Waleckx

et al. 2017

Evolutionary Applications

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The aetiological agent of Chagas disease, Trypanosoma cruzi, is a key human pathogen afflicting most populations of Latin America. This vectorborne parasite is transmitted by haematophageous triatomines, whose control by large‐scale insecticide spraying has been the main strategy to limit the impact of the disease for over 25 years. While those international initiatives have been successful in highly endemic areas, this systematic approach is now challenged by the emergence of insecticide resistance and by its low efficacy in controlling species that are only partially adapted to human habitat. In this contribution, we review evidences that Chagas disease control shall now be entering a second stage that will rely on a better understanding of triatomines adaptive potential, which requires promoting microevolutionary studies and –omic approaches. Concomitantly, we show that our knowledge of the determinants of the evolution of T. cruzi high diversity and low virulence remains too limiting to design evolution‐proof strategies, while such attributes may be part of the future of Chagas disease control after the 2020 WHO's target of regional elimination of intradomiciliary transmission has been reached. We should then aim at developing a theory of T. cruzi virulence evolution that we anticipate to provide an interesting enrichment of the general theory according to the specificities of transmission of this very generalist stercorarian trypanosome. We stress that many ecological data required to better understand selective pressures acting on vector and parasite populations are already available as they have been meticulously accumulated in the last century of field research. Although more specific information will surely be needed, an effective research strategy would be to integrate data into the conceptual and theoretical framework of evolutionary ecology and life‐history evolution that provide the quantitative backgrounds necessary to understand and possibly anticipate adaptive responses to public health interventions.

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Section: Triatomine Life‐history Evolution and Vector Control Challengesmentioning

confidence: 99%

Evolutionary ecology of Chagas disease; what do we know and what do we need?

Flores-Ferrer

Marcou

Waleckx

et al. 2017

Evolutionary Applications

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“…In Bolivia, increasing number of reports denote that the frequency and geographical spread of resistance are much higher than ever thought in the early 1990s when control actions were designed (Lardeux et al 2010, Bustamante Gomez et al 2014, Bustamante Gomez et al 2016), which calls for the increase in surveillance of the populations targeted for control. In this context, the insecticide resistance profile in all three T. infestans populations evaluated from the Santa Cruz Department showed lower RR values than populations observed in other areas of Bolivia, particularly when compared with domestic populations (Germano et al 2010, Lardeux et al 2010, Depickère et al 2012, Bustamante Gomez et al 2015, Gorla et al 2015, Roca-Acevedo et al 2015). However, the toxicological analyses showed significant levels of resistance (RR50s) toward deltamethrin and α-cypermethrin in all three communities.…”

Section: Discussionmentioning

confidence: 67%

Toxicological, Enzymatic, and Molecular Assessment of the Insecticide Susceptibility Profile ofTriatoma infestans(Hemiptera: Reduviidae, Triatominae) Populations From Rural Communities of Santa Cruz, Bolivia

Santo-Orihuela¹,

Vassena

Carvajal³

et al. 2016

J Med Entomol

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A wide range of insecticide resistance profiles has been reported across Bolivian domestic and sylvatic populations of Triatoma infestans (Klug, 1834) (Hemiptera, Reduviidae), including some with levels proven to be a threat for vector control. In this work, the insecticide profile of domestic T. infestans was studied with standardized toxicological bioassays, in an area that has not undergone consistent vector control. F1 first-instarnymphs hatched in laboratory from bugs captured in three communities from the Santa Cruz Department were evaluated with different insecticides. Moreover, the enzymatic activity of esterases and cytochrome P450 monooxygenases was measured in individual insects to evaluate the possible mechanism of metabolic resistance to pyrethroids. In addition, the DNA sequence of sodium channel gene (kdr) was screened for two point mutations associated with pyrethroid resistance previously reported in T. infestans. All populations showed reduced susceptibility to deltamethrin and α-cypermethrin, albeit the RR50 values varied significantly among them. Increased P450 monooxygenases and permethrate esterases suggest the contribution, as detoxifying mechanisms, to the observed resistance to deltamethrin in all studied populations. No individuals presented either mutation associated to resistance in the kdr gene. The level of susceptibility to α-cypermethrin, the insecticide used by the local vector control program, falls within an acceptable range to continue its use in these populations. However, the observed RR50 values evidence the possibility of selection for resistance to pyrethroids, especially to deltamethrin. Consequently, the use of pyrethroid insecticides should be closely monitored in these communities, which should be kept under entomological surveillance and sustained interventions.

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“…T. infestans has high anthropophily, high colonisation capacity and high rates of infection. Because of these features, this triatominae is the main vector in the countries where it occurs, Bolivia, Argentina and Paraguay ( Silveira 2002 , Coura & Dias 2009 ), where T. infestans populations that are resistant to pyrethroid insecticides have been a problem for the Chagas disease control ( Vassena & Picollo 2003 , Audino et al 2004 , Picollo et al 2005 , Toloza et al 2008 , Germano et al 2010 , Lardeux et al 2010 , Gomez et al 2015) . In order to obtain the transcriptional profile of T. infestans , a total of seven samples from two Bolivian populations (Chaco and Bolivian Valley) were used.…”

mentioning

confidence: 99%