Inherent Risks Associated With Manufacture of Bioengineered Ocular Surface Tissue

Ex Vivo Cultivation of Corneal Limbal Epithelial Cells in a Thermoreversible Polymer (Mebiol Gel) and Their Transplantation in Rabbits: An Animal Model

“…28 This is important as it avoids many issues associated with the use of an animal product. 41–44 Thus, though there are risks associated with corneal tissue engineering and more work is required to identify the most ideal scaffold, particularly to understand signal transduction between the cells, the present study indicated that Mebiol Gel may be the near-ideal scaffold for corneal LSC transplantation, because it is biodegradable, thermoreversible, and cells of corneal limbus cultivated in this gel mimic the LSC niche and the possibility of easy method of suture-less transplantation.…”

Ex Vivo Cultivation of Corneal Limbal Epithelial Cells in a Thermoreversible Polymer (Mebiol Gel) and Their Transplantation in Rabbits: An Animal Model

“…28 This is important as it avoids many issues associated with the use of an animal product. 41–44 Thus, though there are risks associated with corneal tissue engineering and more work is required to identify the most ideal scaffold, particularly to understand signal transduction between the cells, the present study indicated that Mebiol Gel may be the near-ideal scaffold for corneal LSC transplantation, because it is biodegradable, thermoreversible, and cells of corneal limbus cultivated in this gel mimic the LSC niche and the possibility of easy method of suture-less transplantation.…”

Outcomes of Limbal Stem Cell Transplant

“…The full text of the remaining 74 articles were reviewed. Forty studies were eligible and included in this meta-analysis (eFigure 1 in the Supplement).…”

“…Among 1576 eyes from 28 studies, 922 eyes (58.5%) obtained 2-line improvement of Snellen VA after LSCT. Fifteen studies provided the details of preoperative and postoperative VA (eFigure 2 in the Supplement) . Mean (SD) LogMar VA improved from 2.1 (0.2) before LSCT to 0.7 (0.2) after the surgery ( P < .001).…”

Cellular Response of Limbal Stem Cells on PHBV/Gelatin Nanofibrous Scaffold for Ocular Epithelial Regeneration

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Ex Vivo Cultivation of Corneal Limbal Epithelial Cells in a Thermoreversible Polymer (Mebiol Gel) and Their Transplantation in Rabbits: An Animal Model

“…28 This is important as it avoids many issues associated with the use of an animal product. 41–44 Thus, though there are risks associated with corneal tissue engineering and more work is required to identify the most ideal scaffold, particularly to understand signal transduction between the cells, the present study indicated that Mebiol Gel may be the near-ideal scaffold for corneal LSC transplantation, because it is biodegradable, thermoreversible, and cells of corneal limbus cultivated in this gel mimic the LSC niche and the possibility of easy method of suture-less transplantation.…”

Outcomes of Limbal Stem Cell Transplant

“…The full text of the remaining 74 articles were reviewed. Forty studies were eligible and included in this meta-analysis (eFigure 1 in the Supplement).…”

“…Among 1576 eyes from 28 studies, 922 eyes (58.5%) obtained 2-line improvement of Snellen VA after LSCT. Fifteen studies provided the details of preoperative and postoperative VA (eFigure 2 in the Supplement) . Mean (SD) LogMar VA improved from 2.1 (0.2) before LSCT to 0.7 (0.2) after the surgery ( P < .001).…”

Cellular Response of Limbal Stem Cells on PHBV/Gelatin Nanofibrous Scaffold for Ocular Epithelial Regeneration

“……”

Ex Vivo Cultivation of Corneal Limbal Epithelial Cells in a Thermoreversible Polymer (Mebiol Gel) and Their Transplantation in Rabbits: An Animal Model

“…28 This is important as it avoids many issues associated with the use of an animal product. 41–44 Thus, though there are risks associated with corneal tissue engineering and more work is required to identify the most ideal scaffold, particularly to understand signal transduction between the cells, the present study indicated that Mebiol Gel may be the near-ideal scaffold for corneal LSC transplantation, because it is biodegradable, thermoreversible, and cells of corneal limbus cultivated in this gel mimic the LSC niche and the possibility of easy method of suture-less transplantation.…”

Outcomes of Limbal Stem Cell Transplant

“…The full text of the remaining 74 articles were reviewed. Forty studies were eligible and included in this meta-analysis (eFigure 1 in the Supplement).…”

“…Among 1576 eyes from 28 studies, 922 eyes (58.5%) obtained 2-line improvement of Snellen VA after LSCT. Fifteen studies provided the details of preoperative and postoperative VA (eFigure 2 in the Supplement) . Mean (SD) LogMar VA improved from 2.1 (0.2) before LSCT to 0.7 (0.2) after the surgery ( P < .001).…”

Cellular Response of Limbal Stem Cells on PHBV/Gelatin Nanofibrous Scaffold for Ocular Epithelial Regeneration

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