Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults

Multicenter Randomized Controlled Trial of Inhaled Nitric Oxide for Pediatric Acute Respiratory Distress Syndrome

“…10,11 Studies in adult ARDS have not demonstrated improved outcomes with iNO. 9 However, as the findings of our study demonstrate, the conclusions of those studies may not necessarily be applicable to children with ARDS for several reasons. The host, etiologies, and pathophysiologic response to acute lung injury differ considerably between children and adults.…”

Multicenter Randomized Controlled Trial of Inhaled Nitric Oxide for Pediatric Acute Respiratory Distress Syndrome

“…10,11 Studies in adult ARDS have not demonstrated improved outcomes with iNO. 9 However, as the findings of our study demonstrate, the conclusions of those studies may not necessarily be applicable to children with ARDS for several reasons. The host, etiologies, and pathophysiologic response to acute lung injury differ considerably between children and adults.…”

Initiation of Inhaled Nitric Oxide by an Air Transport Team in Adult Coronavirus Disease 2019 Respiratory Failure

“…Renal impairment was described in trials in which iNO was used in-hospital and for longer durations than would occur in the air transport environment. 21,22 Methemoglobinemia is secondary to the metabolic breakdown of iNO, however in our series iNO was initiated at 20 or 40 ppm and studies have shown that methemoglobinemia does not occur at these doses. 23 Starting in the fall of 2020, advances in technology as well as clinical and operational capabilities have allowed UW Health Med Flight to expand its specialty flight profiles to include iNO.…”

Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity

“…Other recent meta-analyses of NO found no improvement in mortality and an increased risk of renal failure despite modest improvements in oxygénation (7,8 The z test for subgroup interaction was nof statistically significant (p = 0.53). Total patient numbers differed from fhe original publication for one trial (49).…”

Multicenter Randomized Controlled Trial of Inhaled Nitric Oxide for Pediatric Acute Respiratory Distress Syndrome

“…10,11 Studies in adult ARDS have not demonstrated improved outcomes with iNO. 9 However, as the findings of our study demonstrate, the conclusions of those studies may not necessarily be applicable to children with ARDS for several reasons. The host, etiologies, and pathophysiologic response to acute lung injury differ considerably between children and adults.…”

Initiation of Inhaled Nitric Oxide by an Air Transport Team in Adult Coronavirus Disease 2019 Respiratory Failure

“…Renal impairment was described in trials in which iNO was used in-hospital and for longer durations than would occur in the air transport environment. 21,22 Methemoglobinemia is secondary to the metabolic breakdown of iNO, however in our series iNO was initiated at 20 or 40 ppm and studies have shown that methemoglobinemia does not occur at these doses. 23 Starting in the fall of 2020, advances in technology as well as clinical and operational capabilities have allowed UW Health Med Flight to expand its specialty flight profiles to include iNO.…”

Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity

“…Other recent meta-analyses of NO found no improvement in mortality and an increased risk of renal failure despite modest improvements in oxygénation (7,8 The z test for subgroup interaction was nof statistically significant (p = 0.53). Total patient numbers differed from fhe original publication for one trial (49).…”

Multicenter Randomized Controlled Trial of Inhaled Nitric Oxide for Pediatric Acute Respiratory Distress Syndrome

“…10,11 Studies in adult ARDS have not demonstrated improved outcomes with iNO. 9 However, as the findings of our study demonstrate, the conclusions of those studies may not necessarily be applicable to children with ARDS for several reasons. The host, etiologies, and pathophysiologic response to acute lung injury differ considerably between children and adults.…”

Initiation of Inhaled Nitric Oxide by an Air Transport Team in Adult Coronavirus Disease 2019 Respiratory Failure

“…Renal impairment was described in trials in which iNO was used in-hospital and for longer durations than would occur in the air transport environment. 21,22 Methemoglobinemia is secondary to the metabolic breakdown of iNO, however in our series iNO was initiated at 20 or 40 ppm and studies have shown that methemoglobinemia does not occur at these doses. 23 Starting in the fall of 2020, advances in technology as well as clinical and operational capabilities have allowed UW Health Med Flight to expand its specialty flight profiles to include iNO.…”

Inhaled Nitric Oxide Does Not Reduce Mortality in Patients With Acute Respiratory Distress Syndrome Regardless of Severity

“…Other recent meta-analyses of NO found no improvement in mortality and an increased risk of renal failure despite modest improvements in oxygénation (7,8 The z test for subgroup interaction was nof statistically significant (p = 0.53). Total patient numbers differed from fhe original publication for one trial (49).…”