“…and prescribes an intervention as a 'disease modifying therapy' (DMT) that targets change in the underlying disease process leading to cell death [52]. The mechanisms and determinants are many [53] and predominantly involve nutritional deficiency [54], inflammation [55], oxidative stress [56], mitochondrial dysfunction [57], impaired methylation pathways [58], impaired Aβ clearance [43], hormone imbalance [59], chronic stress [60], gut dysbiosis [61], insulin dysregulation [62], infections [40,[63][64][65][66], poor sleep [67], vascular disease [68], and toxicity [41,60,69,70], including heavy metals [71][72][73][74][75].…”