Inhalation of progesterone inhibits chronic airway inflammation of mice exposed to ozone

Xia, Fei; Bao, Wuping; Zhang, Pengyu; Zhang, Xue; Zhang, Guoqing; Zhang, Yingying; Zhou, Xin; Zhang, Min

doi:10.1016/j.molimm.2017.02.006

Cited by 17 publications

(11 citation statements)

References 50 publications

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“…Chronic obstructive pulmonary disease (COPD) is a major health problem, and its incidence has continued to increase globally in the past decade (1,2). Airway inflammation, one of the main forms of COPD, is caused by cigarette smoking and its pathogenesis is closely associated with increased levels of inflammatory molecules (3).…”

Section: Introductionmentioning

confidence: 99%

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

et al. 2019

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Pistacia weinmannifolia (PW) has been used in traditional Chinese medicine to treat headaches, dysentery, enteritis and influenza. However, PW has not been known for treating respiratory inflammatory diseases, including chronic obstructive pulmonary disease (COPD). The present in vitro analysis confirmed that PW root extract (PWRE) exerts anti-inflammatory effects in phorbol myristate acetate- or tumor necrosis factor α (TNF-α)-stimulated human lung epithelial NCI-H292 cells by attenuating the expression of interleukin (IL)-8, IL-6 and Mucin A5 (MUC5AC), which are closely associated with the pulmonary inflammatory response in the pathogenesis of COPD. Thus, the aim of the present study was to evaluate the protective effect of PWRE on pulmonary inflammation induced by cigarette smoke (CS) and lipopoly-saccharide (LPS). Treatment with PWRE significantly reduced the quantity of neutrophils and the levels of inflammatory molecules and toxic molecules, including tumor TNF-α, IL-6, IL-8, monocyte chemoattractant protein-1, neutrophil elastase and reactive oxygen species, in the bronchoalveolar lavage fluid of mice with CS- and LPS-induced pulmonary inflammation. PWRE also attenuated the influx of inflammatory cells in the lung tissues. Furthermore, PWRE downregulated the activation of nuclear factor-κB and the expression of phosphodiesterase 4 in the lung tissues. Therefore, these findings suggest that PWRE may be a valuable adjuvant treatment for COPD.

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Section: Introductionmentioning

confidence: 99%

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

et al. 2019

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“…Furthermore, animal studies showed progesterone ability to promote lung repair and recovery by inducing epidermal growth factor amphiregulin (Areg), protecting thus adult female mice against lethal Influenza A virus (IAV) infection ( 11 , 15 ). Progesterone was also found to be effective in the mitigation of noninfectious inflammatory lung injuries in animal models, where even inhalation of progesterone provided protection ( 5 ).…”

mentioning

confidence: 99%

Sex differences in COVID-19 course and outcome: progesterone should not be neglected

Jakovac

2020

Journal of Applied Physiology

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“…Ozone exposure has been shown to disrupt largeairway function in mice. 9,19,20 Similarly, we have shown that ozone exposure can induce a decline in FEV50.…”

Section: Discussionmentioning

confidence: 55%

“…Ozone exposure has been shown to disrupt large-airway function in mice. 9 , 19 , 20 Similarly, we have shown that ozone exposure can induce a decline in FEV50. Furthermore, in the present study, we emphasized the impairment of small-airway function in mouse models of asthma.…”

Section: Discussionmentioning

confidence: 61%

“…To evaluate lung function in mice, some studies of the large airways have been conducted through evaluation of the FEV0.1 (volume expired in the first 0.1 s of fast expiration) and FEV25 (volume expired in the first 25 ms of fast expiration) 8 , 9 using various test systems, similar to studies of the FEV1 (volume expired in the first 1 s of fast expiration) in humans. However, little attention has been given to the evaluation of small-airway function in an animal model of asthma.…”

Section: Introductionmentioning

confidence: 99%

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Small-Airway Dysfunction is Involved in the Pathogenesis of Asthma: Evidence from Two Mouse Models

Xue

Bao

Zhou

et al. 2021

JAA

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Background: There has been growing evidence of small-airway dysfunction in patients with asthma. Few studies have evaluated the mechanism of small-airway dysfunction in mouse models of asthma. Purpose: We explored the correlation between small-airway spirometric variables and large-airway function or inflammation in different endotypes of asthma. Methods: Ovalbumin (OVA) sensitization/challenge was used to produce a type 2 (T2)-high asthma model, and OVA combined with ozone exposure (OVA + ozone) was used for the T2low asthma model with increased neutrophils. Spirometry, airway responsiveness, cytokine levels in bronchoalveolar lavage fluid (BALF), and pathological analyses of lung slices stained with hematoxylin-eosin, periodic acid-Schiff, and Masson's trichrome stain were all determined. Muc5ac expression in lung tissue was evaluated by the reverse transcriptionpolymerase chain reaction (RT-PCR), and alpha-smooth muscle actin was measured by immunohistochemistry. Results: Inflammatory cells infiltrated the lung tissue and inflammatory cytokines were increased in the BALF of both the OVA and OVA + ozone groups, compared with the control group. Peribronchial hypersecretion and collagen deposition were evident in the models. The OVA + ozone group showed greater neutrophilic infiltration and peribronchial smooth muscle proliferation than the OVA group. Large-airway obstruction, small-airway dysfunction, and airway hyperresponsiveness were confirmed in both models. Small-airway functional variables, such as MMEF (mean midexpiratory flow, average flow from 25 to 75% forced vital capacity [FVC]) and FEF50 (forced expiratory flow at 50% of FVC), were positively correlated with large-airway function and had a stronger negative correlation with airway inflammation, mucus secretion, and responsiveness than large-airway function. Conclusion: Small-airway dysfunction was evident in the two endotypes of asthma and was correlated with severe airway inflammation, mucus hypersecretion, and airway hyperresponsiveness. The small airways may be an important target in asthma treatment, and further research in the role of small-airway variables in the pathogenesis of asthma is warranted.

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Inhalation of progesterone inhibits chronic airway inflammation of mice exposed to ozone

Cited by 17 publications

References 50 publications

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

Pistacia weinmannifolia ameliorates cigarette smoke and lipopolysaccharide‑induced pulmonary inflammation by inhibiting interleukin‑8 production and NF‑κB activation

Sex differences in COVID-19 course and outcome: progesterone should not be neglected

Small-Airway Dysfunction is Involved in the Pathogenesis of Asthma: Evidence from Two Mouse Models

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