Inhalable magnetic nanoparticles for targeted hyperthermia in lung cancer therapy

Abstract

Lung cancer (specifically, non-small cell lung cancer; NSCLC) is the leading cause of cancer-related deaths in the United States. Poor response rates and survival with current treatments clearly indicate the urgent need for developing an effective means to treat NSCLC. Magnetic hyperthermia is a non-invasive approach for tumor ablation, and is based on heat generation by magnetic materials, such as superparamagnetic iron oxide (SPIO) nanoparticles, when subjected to an alternating magnetic field. However, inadequate delivery of magnetic nanoparticles to tumor cells can result in sub-lethal temperature change and induce resistance while non-targeted delivery of these particles to the healthy tissues can result in toxicity. In our studies, we evaluated the effectiveness of tumor-targeted SPIO nanoparticles for magnetic hyperthermia of lung cancer. EGFR-targeted, inhalable SPIO nanoparticles were synthesized and characterized for targeting lung tumor cells as well as for magnetic hyperthermia-mediated antitumor efficacy in a mouse orthotopic model of NSCLC. Our results show that EGFR targeting enhances tumor retention of SPIO nanoparticles. Further, magnetic hyperthermia treatment using targeted SPIO nanoparticles resulted in significant inhibition of in vivo lung tumor growth. Overall, this work demonstrates the potential for developing an effective anticancer treatment modality for the treatment of NSCLC based on targeted magnetic hyperthermia.

Harmful at non-cytotoxic concentrations: SiO2-SPIONs affect surfactant metabolism and lamellar body biogenesis in A549 human alveolar epithelial cells

“…The intrapulmonary administration of nanoparticles (NPs) is an attractive approach in nanomedicine (Mansour et al, 2009;Sadhukha et al, 2013). In medical applications, superparamagnetic iron oxide nanoparticles (SPIONs) have been reported to be a good choice (Sadhukha et al, 2013).…”

Loco-regional administration of nanomedicines for the treatment of lung cancer

“…The nanoparticles were administered to mice carrying an orthotopic lung cancer model using an ultrasonic atomizer (MMAD 1.1 mm) and EGFR targeting induced enhanced tumor retention and resulted in significant reduction of lung tumor growth over controls, i.e. animals non-treated, treated with non-targeted nanoparticles, or treated with targeted or non-targeted SPIONs but not subjected to the magnetic hyperthermia treatment (Sadhukha et al, 2013).…”

Photothermal therapy of melanoma tumor using multiwalled carbon nanotubes

“…Internalized nanoparticles (NPs) to the tumor sites could be stimulated by laser irradiation, to produce localized heat in the range of 40°C-45°C so as to destroy cancer cells. [2][3][4][5] NPs such as single-walled carbon nanotubes, 6 multiwalled carbon nanotubes (MWNTs), 7,8 graphene, 9,10 iron oxide NPs, 11 gold nanorods, 12 and gold nanoshells 13,14 are used to transform NIR radiation to vibrational energy. Therefore, heat generation based on laser irritation could elevate malignant tissues' temperature and destroy tumors.…”