2004
DOI: 10.1111/j.1538-7836.2004.01067.x
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Abstract: Summary. Background: Quercetin, a flavonoid present in the human diet, which is found in high levels in onions, apples, tea and wine, has been shown previously to inhibit platelet aggregation and signaling in vitro. Consequently, it has been proposed that quercetin may contribute to the protective effects against cardiovascular disease of a diet rich in fruit and vegetables. Objectives: A pilot human dietary intervention study was designed to investigate the relationship between the ingestion of dietary querce… Show more

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Cited by 239 publications
(227 citation statements)
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“…20,21,[55][56][57] Although the flavonoid concentrations used in these experimental studies generally exceeded the levels obtainable with typical dietary intake, there was some overlap with the plasma levels of flavonoids observed in feeding studies in humans. For example, the quercetin plasma concentrations observed in several studies where participants ingested 20-100 mg of quercetin, levels comparable with the intakes for women in quintiles 4 and 5 of our study population, were within the range of the quercetin concentrations associated with decreased proliferation of ovarian cancer cells in a study by Scambia et al [57][58][59] This analysis is the largest and most comprehensive assessment of the association between total dietary flavonoid intake and ovarian cancer risk to date. Strengths include the prospective data with multiple dietary assessments over 18 years of follow-up, and detailed covariate information.…”
Section: Discussionmentioning
confidence: 93%
“…20,21,[55][56][57] Although the flavonoid concentrations used in these experimental studies generally exceeded the levels obtainable with typical dietary intake, there was some overlap with the plasma levels of flavonoids observed in feeding studies in humans. For example, the quercetin plasma concentrations observed in several studies where participants ingested 20-100 mg of quercetin, levels comparable with the intakes for women in quintiles 4 and 5 of our study population, were within the range of the quercetin concentrations associated with decreased proliferation of ovarian cancer cells in a study by Scambia et al [57][58][59] This analysis is the largest and most comprehensive assessment of the association between total dietary flavonoid intake and ovarian cancer risk to date. Strengths include the prospective data with multiple dietary assessments over 18 years of follow-up, and detailed covariate information.…”
Section: Discussionmentioning
confidence: 93%
“…Epidemiological studies, together with data from animal models and some clinical trials, suggest a role of dietary flavonoids in the prevention of CVD and other age-related chronic diseases (108)(109)(110) . The flavonol quercetin exhibits a wide range of physiological effects such as inhibition of LDL-oxidation, lowering of arterial blood pressure and platelet aggregation, and improvement of endothelial function as shown in animal models and in human subjects (111)(112)(113)(114)(115)(116)(117) . Furthermore, cell culture and animal studies indicate a potent anti-inflammatory activity of quercetin (116,(118)(119)(120) .…”
Section: Flavonoidsmentioning
confidence: 99%
“…After collagen stimulation, increased tyrosine phosphorylation was observed on multiple signaling molecules; tyrosine phosphorylation was greatly inhibited in the presence of quercetin, which is consistent with previous reports (Figure 2A). 6,7 Resveratrol had no effects on protein tyrosine phosphorylation (Figure 2A). In marked contrast, both MBA and CS caused increases in basal levels of tyrosine phosphorylation in multiple proteins (Figure 2A).…”
Section: Muscat Bailey A-and Cs-enhanced Protein Tyrosine Phosphorylamentioning
confidence: 99%
“…5 Quercetin also reportedly inhibits platelet aggregation by inhibiting protein tyrosine kinase. 6,7 More recently, human studies have shown that polyphenol-rich crude extracts from grape seeds or skins inhibit platelet aggregation that was induced by thrombin-receptor agonist peptide (TRAP) or collagen, [8][9][10] and that ingestion of grape seed extract (GSE) inhibits ADP or collagen-induced platelet aggregation in humans. 11,12 However, the mechanism of GSE inhibition of platelet activation has not been fully elucidated to date.…”
Section: Introductionmentioning
confidence: 99%