Ingestion of Angelʼs Trumpet: An increasingly Common Source of Toxicity

Greene, G S; Patterson, Stephen; Warner, Elizabeth

doi:10.1097/00007611-199604000-00002

Cited by 51 publications

(35 citation statements)

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“…207 Jimson weed has also been used as a drug of abuse, because of its hallucinogenic properties. 208,209 Other plants that can cause anticholinergic poisoning include angel's trumpet (Brugmansia spp., now called Datura), 210 found in Central and South America and prepared as a tea for its hallucinogenic effects and jessamine (Gelsemium semper virens; Figure 76.28), 211 which is native to North and Central America.…”

Section: Anticholinergic Compoundsmentioning

confidence: 99%

Plant Poisons and Traditional Medicines

Aronson¹

2014

Manson's Tropical Infectious Diseases

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Section: Anticholinergic Compoundsmentioning

confidence: 99%

Plant Poisons and Traditional Medicines

Aronson¹

2014

Manson's Tropical Infectious Diseases

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“…They are also referred to as belladonna alkaloids and consist of atropine, hyoscyamine and scopolamine. Datura stramonium (Angel's trumpet, jimsonweed) is the most widespread of the tropane alkaloid-containing plants in the U.S.; intoxication is primarily reported in people using the plant for its hallucinogenic properties [1,38,39]. D. stramonium seeds contain the highest concentration of alkaloids (0.4%) followed by leaves and flowers (0.2%) [4].…”

Section: Tropane Alkaloidsmentioning

confidence: 99%

“…Clinical signs of intoxication in decreasing order of frequency include mydriasis, hyperreflexia, skin flushing, delirium, hallucinations, tachycardia and dry skin and membranes [1,38,39]. Signs that occur less frequently but are associated with serious complications include seizures, rhabdomyolysis, and respiratory and renal failure.…”

Section: Tropane Alkaloidsmentioning

confidence: 99%

Poisonous plants

Poppenga

2010

Experientia Supplementum

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Abstract. A large number of plants can cause adverse effects when ingested by animals or people. Plant toxicity is due to a wide diversity of chemical toxins that include alkaloids, glycosides, proteins and amino acids. There are several notable toxic plants for which a specific chemical responsible for toxicity has not been determined. There are many examples of species differences in terms of their sensitivity to intoxication from plants. Pets, such as dogs and cats, and people, especially children, are frequently exposed to the same toxic plants due to their shared environments. On the other hand, livestock are exposed to toxic plants that are rarely involved in human intoxications due to the unique environments in which they are kept. Fortunately, adverse effects often do not occur or are generally mild following most toxic plant ingestions and no therapeutic intervention is necessary. However, some plants are extremely toxic and ingestion of small amounts can cause rapid death. The diagnosis of plant intoxication can be challenging, especially in veterinary medicine where a history of exposure to a toxic plant is often lacking. Analytical tests are available to detect some plant toxins, although their diagnostic utility is often limited by test availability and timeliness of results. With a few notable exceptions, antidotes for plant toxins are not available. However, general supportive and symptomatic care often is sufficient to successfully treat a symptomatic patient.

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“…Intoxications have been registered also after dietary exposure to other Datura species, such as Datura aurea (Belton and Gibbons, 1979, Wilhelm et al, 1991), Datura candida (McHenry and Hall, 1978Wilhelm et al, 1991;Greene et al, 1996), Datura cornigera (Belton and Gibbons, 1979), Datura inoxia (Pekdemir et al, 2004;Raman and Jacob, 2005), Datura rosei (Hudson, 1973), Datura sanguinea (Belton and Gibbons, 1979;Wilhelm et al, 1991), and Datura suaveolens (McHenry and Hall, 1978;Wilhelm et al, 1991;Greene et al, 1996;Havelius and Åsman, 2002). Some of these species or varieties are known under the name Angels Trumpet and are common ornamental garden plants as well as indoor plants because of their beautiful trumpet-shaped blossoms.…”

Section: Human Intoxicationsmentioning

confidence: 99%

Tropane alkaloids (from Datura sp.) as undesirable substances in animal feed - Scientific Opinion of the Panel on Contaminants in the Food Chain

2008

EFSA Journal

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SUMMARYThe term tropane alkaloids refers to a group of more than 200 compounds best known for their occurrence in the family Solanaceae comprising over 100 genera and 3000 plant species. They have in common a two-ringed structure characterized by a pyrrolidine and a piperidine ring sharing a single nitrogen atom and two carbons atoms. The nitrogen atom at the end of the molecule, which characterizes the compounds as alkaloids, is in this group characteristically methylated. The most important natural tropane alkaloids are (-)-hyoscyamine and (-)-scopolamine (also known as hyoscine). High concentrations of these alkaloids have been found particularly in Datura stramonium and Datura ferox, as well as in Datura innoxia. The pattern of tropane alkaloids differs significantly and in Datura stramonium (also known as thorn apple or Jimson weed) hyoscyamine prevails in most parts of the plant, whereas in Datura ferox scopolamine is the major alkaloid Tropane alkaloids as undesirable substances in animal feedThe EFSA Journal (2008) 691, 2-55 produced. Datura plants are toxic for animals if ingested in larger amounts. Their seeds, which contain significant amounts of hyoscyamine and scopolamine, can be found as botanical impurities in feed materials, particularly in soybean and linseed products.Very little information on the actual contamination of feed materials is available, and previous reports on adverse health effects in animals refer in most cases to accidental intoxications following the consumption of Datura plants rather than to the contamination of linseed and sobean contaning feed materials. Hence no conclusive exposure assessment could be presented for farm animals.Overall, pigs have been shown to be among the most sensitive species to Datura poisoning. A worst case exposure estimate indicated that adverse pharmacological effects in pigs following exposure to Datura ferox seeds, mainly containing scopolamine, can not be entirely excluded at the current statutory limits of 3000 mg/kg feed. However, the limited data also suggested that it is not likely that the presence of Datura stramonium impurities in animals feed up to the current statutory level of 1000 mg/kg would present a risk to animal health.The mechanism of action of tropane alkaloids relates to their competitive antagonism at muscarinic acetylcholine receptors, preventing the binding of acetylcholine. According to the specificity and selectivity of muscarinergic acetylcholine receptors in different organs, the functions of smooth muscles and exocrine gland cells, as well as the heart rate, respiration and functions in the central nervous system are modulated. Certain tropanes such as atropine (the racemic mixture of (-)-and (+)hyoscyamine) as well as scopolamine (mainly as butylscopolamine bromide) are used in human and veterinary therapy for a variety of related indications. Reports of poisoning of livestock and experimental feeding studies describe as most common symptoms associated with tropane alkaloids exposure dryness of the mucosa in the uppe...

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Ingestion of Angelʼs Trumpet: An increasingly Common Source of Toxicity

Cited by 51 publications

References 0 publications

Plant Poisons and Traditional Medicines

Plant Poisons and Traditional Medicines

Poisonous plants

Tropane alkaloids (from Datura sp.) as undesirable substances in animal feed - Scientific Opinion of the Panel on Contaminants in the Food Chain

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