Infrared spectroscopy of live cells from a flowing solution using electrically-biased plasmonic metasurfaces

Kelp, Glen; Li, Joy; Lu, Junlan; DiNapoli, Nicholas; Delgado, Robert; Liu, Chao; Fan, Donglei; Dutta-Gupta, Shourya; Shvets, Gennady

doi:10.1039/c9lc01054h

Cited by 21 publications

(27 citation statements)

References 104 publications

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“…[31] In addition to these relative milestone research developments, there are also many other SEIRA breakthroughs in this decade. [32][33][34][35][36][37][38][39][40][41][42][43][44] As noted before, metamaterial-based SEIRA and its sensing applications have progressed rapidly in the past decade. Moreover, optimization of the signal enhancement to obtain high sensing performance is developing the main thread of SEIRA technology.…”

Section: Introductionmentioning

confidence: 79%

Infrared metamaterial for surface-enhanced infrared absorption spectroscopy: pushing the frontier of ultrasensitive on-chip sensing

Zhou

Hui

et al. 2021

International Journal of Optomechatronics

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Surface-enhanced infrared absorption (SEIRA) spectroscopy is a powerful technique that overcomes the issue of low molecular absorption cross-sections in infrared spectroscopy. Due to the collective oscillations of electrons in the infrared regime, SEIRA using resonant metamaterial provides greatly enhanced (up to 10 7 ) electromagnetic fields extending up to tens of nanometers from the metamaterial. The enhanced near-field enables spectroscopic analysis and ultrasensitive on-chip sensing of molecules. This interesting characteristic has aroused widespread attention from researchers to SEIRA technology, and various SEIRA-based sensing applications have been continuously emerging. Optimization of the signal enhancement to obtain high sensing performance is the developing main thread of SEIRA technology. In this Review, we provide a basic understanding of SEIRA's sensing mechanism and theoretical model. With this background, several SEIRA optimizing methods are discussed, ranging from design, materials to algorithms. Additionally, perspectives about the future development trends of SEIRA technologies are discussed.

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Section: Introductionmentioning

confidence: 79%

Infrared metamaterial for surface-enhanced infrared absorption spectroscopy: pushing the frontier of ultrasensitive on-chip sensing

Zhou

Hui

et al. 2021

International Journal of Optomechatronics

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“…Modifications in cell structure due to normal ageing or destructive changes under different drug therapies will alter the cell movement under DEP, facilitating or impeding single cell separation. [110] Mouse melanoma B16F10 cells DEP has the ability to differentiate between two malignant cells of the same origin, based on their melanin content [111] Human skin fibroblast and human malignant melanocytes Distinguishing healthy and cancer cells using the microfluidic chamber DEP device [112] A375 human skin cancer cells Assessment of the effects of various parameters of nanosecond pulsed electric fields combined with multi-walled carbon nanotubes on skin cancer cells viability [113] A431 human skin cancer cells Separation of A431 cells from liquid samples based on their DEP parameters [114] Another important aspect related to DEP is the continuous improvement of the technique, during the last couple of years, new technological breakthroughs changing also the classical DEP approach. One of the most used DEP techniques is the electrode-based DEP (eDEP) that employs metallic electrodes positioned within a micro-channel, having direct contact with the measured particles and the suspending medium [115].…”

Section: Photoacoustic Flow Cytometrymentioning

confidence: 99%

Liquid Biopsy and Dielectrophoretic Analysis—Complementary Methods in Skin Cancer Monitoring

et al. 2022

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The incidence and prevalence of skin cancers is currently increasing worldwide, with early detection, adequate treatment, and prevention of recurrences being topics of great interest for researchers nowadays. Although tumor biopsy remains the gold standard of diagnosis, this technique cannot be performed in a significant proportion of cases, so that the use of alternative methods with high sensitivity and specificity is becoming increasingly desirable. In this context, liquid biopsy appears to be a feasible solution for the study of cellular and molecular markers relevant to different types of skin cancers. Circulating tumor cells are just one of the components of interest obtained from performing liquid biopsy, and their study by complementary methods, such as dielectrophoresis, could bring additional benefits in terms of characterizing skin tumors and subsequently applying personalized therapy. One purpose of this review is to demonstrate the utility of liquid biopsy primarily in monitoring the most common types of skin tumors: basal cell carcinoma, squamous cell carcinoma, and malign melanoma. In addition, the originality of the article is based on the detailed presentation of the dielectrophoretic analysis method of the most important elements obtained from liquid biopsy, with direct impact on the clinical and therapeutic approach of skin tumors.

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“…In addition, the DEP force has a high biomolecular compatibility compared to EP and ETF force, which require relatively strong electric field and high temperature, respectively. Furthermore, unlike optical trapping force that requires large-scale optical systems and magnetic force that needs a labeling process for magnetic materials, DEP force has high simplicity and compatibility [53]. Such competitiveness of DEP force has led many researchers to develop methods for separating the biomolecules using single DEP or complex DEP force combined with other forces.…”

Section: Novelty Of Dep Force For Convergence Of Various Forcesmentioning

confidence: 99%

Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications

Lee

Roh

Lee

et al. 2020

Sensors

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Since separation of target biomolecules is a crucial step for highly sensitive and selective detection of biomolecules, hence, various technologies have been applied to separate biomolecules, such as deoxyribonucleic acid (DNA), protein, exosome, virus, etc. Among the various technologies, dielectrophoresis (DEP) has the significant advantage that the force can provide two different types of forces, attractive and repulsive DEP force, through simple adjustment in frequency or structure of microfluidic chips. Therefore, in this review, we focused on separation technologies based on DEP force and classified various separation technologies. First, the importance of biomolecules, general separation methods and various forces including DEP, electrophoresis (EP), electrothermal flow (ETF), electroosmosis (EO), magnetophoresis, acoustophoresis (ACP), hydrodynamic, etc., was described. Then, separating technologies applying only a single DEP force and dual force, moreover, applying other forces simultaneously with DEP force were categorized. In addition, advanced technologies applying more than two different kinds of forces, namely complex force, were introduced. Overall, we critically reviewed the state-of-the-art of converged various forces for detection of biomolecules with novelty of DEP.

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Infrared spectroscopy of live cells from a flowing solution using electrically-biased plasmonic metasurfaces

Abstract: Microfluidics, dielectrophoresis (DEP) and metasurface-enhanced infrared reflection spectroscopy (MEIRS) are combined for capturing and rapid spectroscopy of live cells.

Cited by 21 publications

References 104 publications

Infrared metamaterial for surface-enhanced infrared absorption spectroscopy: pushing the frontier of ultrasensitive on-chip sensing

Infrared metamaterial for surface-enhanced infrared absorption spectroscopy: pushing the frontier of ultrasensitive on-chip sensing

Liquid Biopsy and Dielectrophoretic Analysis—Complementary Methods in Skin Cancer Monitoring

Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications

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