Influenza vaccine uptake and distribution in England and Wales using data from the General Practice Research Database, 1989/90–2003/04

Joseph, C; Goddard, Nichola; Gelb, David

doi:10.1093/pubmed/fdi054

Cited by 34 publications

(19 citation statements)

References 8 publications

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“…Nonetheless, international comparisons of pneumonia hospitalizations and drug-prescribing trends may be enlightening. The increase in pneumonia admissions has occurred despite increasing coverage for infl uenza and pneumococcal vaccinations in the elderly (30,31). Since 1992, a 23-valent pneumococcal polysaccharide vaccine (PPV23) has been recommended in England for persons at high risk, and in 2003, this recommendation was extended to include all persons >65 years of age.…”

Section: Discussionmentioning

confidence: 99%

Increasing Hospital Admissions for Pneumonia, England

Trotter

Stuart²,

George³

et al. 2008

Emerg. Infect. Dis.

252

178

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Pneumonia is an important cause of illness and death in England. To describe trends in pneumonia hospitalizations, we extracted information on all episodes of pneumonia that occurred from April 1997 through March 2005 recorded in the Hospital Episode Statistics (HES) database by searching for International Classifi cation of Diseases 10th revision codes J12-J18 in any diagnostic fi eld. The age-standardized incidence of hospitalization with a primary diagnosis of pneumonia increased by 34% from 1.48 to 1.98 per 1,000 population between 1997-98 and 2004-05. The increase was more marked in older adults, in whom the mortality rate was also highest. The proportion of patients with recorded coexisting conditions (defi ned by using the Charlson Comorbidity Index score) increased over the study period. The rise in pneumonia hospital admissions was not fully explained by demographic change or increasing coexisting conditions. It may be attributable to other population factors, changes in HES coding, changes to health service organization, other biologic phenomenon, or a combination of these effects.

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Section: Discussionmentioning

confidence: 99%

Increasing Hospital Admissions for Pneumonia, England

Trotter

Stuart²,

George³

et al. 2008

Emerg. Infect. Dis.

252

178

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show abstract

“…Vaccine coverage estimates for 1989/1990–2004/2005 were adapted from published sources. Published estimates of vaccine coverage were available by age group and separately for persons considered at high or low risk of influenza complications 2 3. Separate estimates by risk group were combined proportionately according to the number of each group vaccinated to give coverage for that age group regardless of the risk group.…”

Section: Methodsmentioning

confidence: 99%

The impact of targeting all elderly persons in England and Wales for yearly influenza vaccination: excess mortality due to pneumonia or influenza and time trend study

et al. 2013

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ObjectiveTo investigate the impact on mortality due to pneumonia or influenza of the change from risk-based to age group-based targeting of the elderly for yearly influenza vaccination in England and Wales.DesignExcess mortality estimated using time series of deaths registered to pneumonia or influenza, accounting for seasonality, trend and artefacts. Non-excess mortality plotted as proxy for long-term trend in mortality.SettingEngland and Wales.ParticipantsPersons aged 65–74 and 75+ years whose deaths were registered to underlying pneumonia or influenza between 1975/1976 and 2004/2005.Outcome measuresMultiplicative effect on average excess pneumonia and influenza deaths each winter in the 4–6 winters since age group-based targeting of vaccination was introduced (in persons aged 75+ years from 1998/1999; in persons aged 65+ years from 2000/2001), estimated using multivariable regression adjusted for temperature, antigenic drift and vaccine mismatch, and stratified by dominant circulating influenza subtype. Trend in baseline weekly pneumonia and influenza death rates.ResultsThere is a suggestion of lower average excess mortality in the six winters after age group-based targeting began compared to before, but the CI for the 65–74 years age group includes no difference. Trend in baseline pneumonia and influenza mortality shows an apparent downward turning point around 2000 for the 65–74 years age group and from the mid-1990s in the 75+ years age group.ConclusionsThere is weakly supportive evidence that the marked increases in vaccine coverage accompanying the switch from risk-based to age group-based targeting of the elderly for yearly influenza vaccination in England and Wales were associated with lower levels of pneumonia and influenza mortality in older people in the first 6 years after age group-based targeting began. The possible impact of these policy changes is observed as weak evidence for lower average excess mortality as well as a turning point in baseline mortality coincident with the changes.

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“…[1][2][3] Analysis of the 2008/2009 uptake figures in England suggests that 23.8% of those aged 2-16 years in an at-risk group were vaccinated, compared with 50.2% of those in an at-risk group aged 16-65 years, and 74.1% of those aged ≥65 years. 3 The vaccination programme for children (aged less than 16 years) in the UK is targeted at specific at-risk groups by the Department of Health.…”

Section: Introductionmentioning

confidence: 99%

Parental reasons for non-uptake of influenza vaccination in young at-risk groups: a qualitative study

Sampson¹,

Wong²,

MacVicar³

2011

Br J Gen Pract

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Influenza vaccine uptake and distribution in England and Wales using data from the General Practice Research Database, 1989/90–2003/04

Abstract: Coverage among high-risk patients in younger age groups continues to fall well below satisfactory levels, especially among the youngest groups. Government policy should now focus on ways to improve uptake in these patients.

Cited by 34 publications

References 8 publications

Increasing Hospital Admissions for Pneumonia, England

Increasing Hospital Admissions for Pneumonia, England

The impact of targeting all elderly persons in England and Wales for yearly influenza vaccination: excess mortality due to pneumonia or influenza and time trend study

Parental reasons for non-uptake of influenza vaccination in young at-risk groups: a qualitative study

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