Influenza-related health care utilization and productivity losses during seasons with and without a match between the seasonal and vaccine virus B lineage

Karve, Sudeep; Meier, Genevieve; Davis, Keith L.; Misurski, Derek; Wang, Chi‐Chuan

doi:10.1016/j.vaccine.2013.04.081

Cited by 20 publications

(32 citation statements)

References 21 publications

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“…Prior studies have raised concerns that mismatches can result in lower vaccine effectiveness, due to the absence of cross-protection between antigenically distinct influenza B lineages, leading to more influenza cases, 8,9 and an increase in influenzarelated medical resource utilization and costs. 2,10 In addition to this, Matias et al 11 have found that influenza B-associated mortality could serve as a surrogate marker of disease severity.…”

Section: Introductionmentioning

confidence: 97%

“…In healthy individuals influenza is generally self-limiting, but can often cause complications. 1,2 There are 3 types of seasonal influenza viruses -A, B, and C. Influenza A causes moderate to severe illness and affects individuals of all age groups. Influenza B can cause disease of similar severity as influenza A, and even though the morbidity is higher in children, all age groups can be affected.…”

Section: Introductionmentioning

confidence: 99%

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Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition

Barros

Cintra

Rossetto³

et al. 2016

The Brazilian Journal of Infectious Diseases

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Data on the burden of disease and circulation patterns of influenza B lineages for Brazil are limited. This review aims to describe the pattern of influenza B occurrence in Brazil to have a better understanding of its epidemiology and its relevance when considering seasonal influenza vaccine composition. A review of the data including analysis of international and local surveillance data as well as information from online search of databases using Medical Subject Headings terms in conjunction with screening of abstracts from scientific events was performed. Based on international epidemiologic surveillance data, moderate levels of influenza B disease (19%; 2006-2014) were observed. Of these nine years, it was possible to compare data from three years (2007, 2008 and 2013) which have information on the circulating influenza B lineage. Co-circulation of influenza B lineages was observed in all these three influenza seasons, of which, during one season, a high degree of mismatch between the vaccine lineage and the predominant circulating lineage (91.4% [2013]) was observed. Local surveillance data reveal a distinct and dynamic distribution of respiratory viruses over the years. Data from published literature and abstracts show that influenza B is a significant cause of disease with an unpredictable circulation pattern and showing trends indicating reemergence of the B/Victoria lineage. The abstracts report notable levels of co-circulation of both influenza B lineages (2000-2013). Mismatch between the Southern hemisphere vaccine and the most prevalent circulating viruses in Brazil were observed in five influenza seasons. The evidence on co-circulation of two influenza B lineages and mismatched seasons in Brazil indicates the benefit of quadrivalent influenza vaccines in conferring broader seasonal influenza protection. Additionally, improving influenza surveillance platforms in Brazil is important for monitoring disease trends and the impact of introducing seasonal influenza vaccination.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition

Barros

Cintra

Rossetto³

et al. 2016

The Brazilian Journal of Infectious Diseases

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“…Since the 1970s, influenza B viruses have belonged to two antigenically distinct lineages called the Victoria and Yamagata lineages; this has been a challenge for seasonal influenza vaccines as only one influenza B strain is included in the trivalent vaccine. Studies in the United States have shown that the frequent influenza B vaccine mismatches of recent years have been associated with substantial increases in cases, hospitalizations and deaths (up to annual 970 000 cases, with 8200 hospitalizations and 485 deaths, in the USA), as well as with large influenza‐related medical costs, and costs associated with productivity loss …”

Section: Introductionmentioning

confidence: 99%

Epidemiological and virological characteristics of influenza B: results of the Global Influenza B Study

Caini

Huang

Cıblak

et al. 2015

Influenza Resp Viruses

162

142

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IntroductionLiterature on influenza focuses on influenza A, despite influenza B having a large public health impact. The Global Influenza B Study aims to collect information on global epidemiology and burden of disease of influenza B since 2000.MethodsTwenty-six countries in the Southern (n = 5) and Northern (n = 7) hemispheres and intertropical belt (n = 14) provided virological and epidemiological data. We calculated the proportion of influenza cases due to type B and Victoria and Yamagata lineages in each country and season; tested the correlation between proportion of influenza B and maximum weekly influenza-like illness (ILI) rate during the same season; determined the frequency of vaccine mismatches; and described the age distribution of cases by virus type.ResultsThe database included 935 673 influenza cases (2000–2013). Overall median proportion of influenza B was 22·6%, with no statistically significant differences across seasons. During seasons where influenza B was dominant or co-circulated (>20% of total detections), Victoria and Yamagata lineages predominated during 64% and 36% of seasons, respectively, and a vaccine mismatch was observed in ≈25% of seasons. Proportion of influenza B was inversely correlated with maximum ILI rate in the same season in the Northern and (with borderline significance) Southern hemispheres. Patients infected with influenza B were usually younger (5–17 years) than patients infected with influenza A.ConclusionInfluenza B is a common disease with some epidemiological differences from influenza A. This should be considered when optimizing control/prevention strategies in different regions and reducing the global burden of disease due to influenza.

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“…Mismatch between formulated IIV3s and the prevalent strains may result in severe illness and economic burden. [2,[44][45][46] The cross-protection against the circulating B lineage not included in the IIV3s is limited. Thus, these vaccines provide inadequate protection in the event of significant co-circulation of both influenza B lineages or during mismatched seasons.…”

Section: Burden Of Influenza B In Europementioning

confidence: 99%

“…[1] Besides being a direct burden on healthcare resources, influenza illnesses and complications are attributed with significant productivity losses to the society. [2][3][4][5] The causative pathogen, influenza virus, belongs to the RNA virus family Orthomyxoviridae and can be classified into A, B, and C types [6]. Influenza attack rates can be 5-10% in adults and as high as 20%-30% in children.…”

mentioning

confidence: 99%

Evidence update: GlaxoSmithKline’s inactivated quadrivalent influenza vaccines

Bekkat-Berkani

Ray

Jain³

et al. 2015

Expert Review of Vaccines

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Inactivated trivalent influenza vaccines (IIV3s) are designed to protect against illness caused by two influenza A virus subtypes and one influenza B virus lineage. They may provide inadequate protection due to the co-circulation of viruses from two antigenically distinct influenza B lineages. Incorporating strains from both B lineages as in inactivated quadrivalent influenza vaccines (IIV4s) reduces this risk. We summarize the evidence supporting two IIV4s manufactured by GSK Vaccines. Compared to IIV3s, these two IIV4s demonstrated noninferior immunogenicity against the shared influenza strains and superior immunogenicity for the strain of the additional B lineage, particularly in subjects who were seronegative for that B strain. One IIV4's efficacy in children aged 3-8 years was 55.4% against influenza of any severity and 73.1% against moderateto-severe influenza. Both IIV4s were well-tolerated with a similar safety profile to IIV3s. These IIV4s are more likely than IIV3s to protect against the added influenza B strain. ARTICLE HISTORY

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Influenza-related health care utilization and productivity losses during seasons with and without a match between the seasonal and vaccine virus B lineage

Cited by 20 publications

References 21 publications

Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition

Patterns of influenza B circulation in Brazil and its relevance to seasonal vaccine composition

Epidemiological and virological characteristics of influenza B: results of the Global Influenza B Study

Evidence update: GlaxoSmithKline’s inactivated quadrivalent influenza vaccines

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