Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza <scp>A</scp> (<scp>H1N1</scp>) pdm09 and <scp>A</scp> (<scp>H3N2</scp>) in the post‐pandemic period

Yang, Shu; Qu, Jiu Xin; Wang, Chen; Yu, Xiao; Liu, Ying Mei; Cao, Bin

doi:10.1111/crj.12056

Cited by 25 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An overview of the studies (Table and Table ) showed a lot of diversity in the populations that were investigated: Studies are presented in terms of hospitalized patients (n = 22) or cover mainly outpatient settings (n = 19), such as primary care (n = 6) or community‐based (n = 4) settings. Most studies were carried out in Asia (n = 17), Europe (n = 15), or North America (n = 8).…”

Section: Resultsmentioning

confidence: 99%

Clinical characteristics and severity of influenza infections by virus type, subtype, and lineage: A systematic literature review

Caini

Kroneman

Wiegers

et al. 2018

Influenza Resp Viruses

View full text Add to dashboard Cite

AimStudies carried out in the early 2000s found that the number of influenza‐associated hospitalizations and deaths was highest in seasons dominated by A(H3N2), suggesting that the clinical presentation and severity of influenza may differ across virus types, subtypes, and lineages. We aimed to review the studies that examined this hypothesis.MethodWe conducted a literature review of studies published until January 2017 that compared the clinical presentation, disease severity, and case‐fatality ratio of influenza patients infected with different virus types (A, B), subtypes (pre‐pandemic A(H1N1), A(H1N1)p, A(H3N2)), and lineages (Victoria, Yamagata).ResultsThe literature search resulted in over 1700 entries: After applying in‐ and exclusion criteria, 47 studies were included in the literature review. Studies showed a wide diversity in setting and populations. Only a minority of studies provided results adjusted by patient's age and other potential confounders. There were very few differences in the clinical presentation of patients infected with different influenza viruses. We found weak evidence that the A(H1N1)p subtype in the post‐pandemic period was more often associated with secondary bacterial pneumonia, ICU admission, and death, than the other influenza virus (sub)types.ConclusionContrary to what is commonly assumed, the causal virus subtype does not seem to be a major determinant of clinical presentation and severity of influenza illness. However, drawing conclusions was made difficult by the low comparability and methodological shortcomings of included studies, and more well‐designed studies are warranted.

show abstract

Section: Resultsmentioning

confidence: 99%

Clinical characteristics and severity of influenza infections by virus type, subtype, and lineage: A systematic literature review

Caini

Kroneman

Wiegers

et al. 2018

Influenza Resp Viruses

View full text Add to dashboard Cite

show abstract

“…The present results are in agreement with another group that reported that IL-10 was found to be higher in influenza A (H1N1)pdm09 patients when compared with other influenza A viruses. However, other influenza viruses in the group of non-(H1N1)pdm09 pneumonia patients were not tested (42,43). IL-17 has been associated with acute lung injury in influenza A (H1N1)pdm09 patients (24).…”

Section: Discussionmentioning

confidence: 99%

TGF-β Blood Levels Distinguish Between Influenza A (H1N1)pdm09 Virus Sepsis and Sepsis due to Other Forms of Community-Acquired Pneumonia

et al. 2015

View full text Add to dashboard Cite

There is a strong interest in finding adequate biomarkers to aid in the diagnosis and prognosis of influenza A (H1N1)pdm09 virus infection. In this study, serum levels of inflammatory cytokines and laboratory markers were evaluated to assess their usefulness as biomarkers of influenza A (H1N1)pdm09 and their association with fatal cases. Serum samples of consecutive patients with a clinical presentation suggestive of influenza A (H1N1)pdm09 and progression to sepsis were evaluated. Serum inflammatory cytokines and routine laboratory tests were performed and correlated with positivity for influenza A (H1N1)pdm09 influenza by real time reverse transcription polymerase chain reaction and the results of three clinical severity scores (Sequential Organ Failure Assessment [SOFA], CURB-65, and Acute Physiology and Chronic Health Evaluation II [APACHE II]). High SOFA scores and some of its individual components, but not CURB-65 or APACHE II scores, correlate with fatal cases regardless of etiology. Total and unconjugated bilirubin, Ca + + , Cl -, prothrombin times, and partial thromboplastin times discriminate influenza A (H1N1)pdm09 from other causes of community-acquired pneumonia.

show abstract

“…Corticosteroids were widely used in patients with severe influenza infection. The use of corticosteroids is based on the underlying pathogenesis of severe influenza infection, which is characterized by overproduction of proinflammatory cytokines/chemokines and an excess of activated lymphocytes, which may result in severe lung damage and delayed recovery . Moreover, animal model studies also found that corticosteroid treatment decreased mortality and ameliorated the acute lung injury induced by influenza A(H1N1)pdm09 virus .…”

Section: Introductionmentioning

confidence: 99%

Effect of low‐to‐moderate‐dose corticosteroids on mortality of hospitalized adolescents and adults with influenza A(H1N1)pdm09 viral pneumonia

Yang

et al. 2017

Influenza Resp Viruses

Self Cite

135

137

View full text Add to dashboard Cite

BackgroundThe effect of corticosteroids on influenza A(H1N1)pdm09 viral pneumonia patients remains controversial, and the impact of dosage has never been studied.MethodsUsing data of hospitalized adolescent and adult patients with influenza A(H1N1)pdm09 viral pneumonia, prospectively collected from 407 hospitals in mainland China, the effects of low‐to‐moderate‐dose (25‐150 mg d−1) and high‐dose (>150 mg d−1) corticosteroids on 30‐day mortality, 60‐day mortality, and nosocomial infection were assessed with multivariate Cox regression and propensity score‐matched case–control analysis.ResultsIn total, 2141 patients (median age: 34 years; morality rate: 15.9%) were included. Among them, 1160 (54.2%) had PaO2/FiO2<300 mm Hg on admission, and 1055 (49.3%) received corticosteroids therapy. Corticosteroids, without consideration of dose, did not influence either 30‐day or 60‐day mortality. Further analysis revealed that, as compared with the no‐corticosteroid group, low‐to‐moderate‐dose corticosteroids were related to reduced 30‐day mortality (adjusted hazard ratio [aHR] 0.64 [95% CI 0.43‐0.96, P=.033]). In the subgroup analysis among patients with PaO2/FiO2<300 mm Hg, low‐to‐moderate‐dose corticosteroid treatment significantly reduced both 30‐day mortality (aHR 0.49 [95% CI 0.32‐0.77]) and 60‐day mortality (aHR 0.51 [95% CI 0.33‐0.78]), while high‐dose corticosteroid therapy yielded no difference. For patients with PaO2/FiO2 ≥300 mm Hg, corticosteroids (irrespective of dose) showed no benefit and even increased 60‐day mortality (aHR 3.02 [95% CI 1.06‐8.58]). Results were similar in the propensity model analysis.ConclusionsLow‐to‐moderate‐dose corticosteroids might reduce mortality of influenza A(H1N1)pdm09 viral pneumonia patients with PaO2/FiO2<300 mm Hg. Mild patients with PaO2/FiO2 ≥300 mm Hg could not benefit from corticosteroid therapy.

show abstract

Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza A (H1N1) pdm09 and A (H3N2) in the post‐pandemic period

Cited by 25 publications

References 22 publications

Clinical characteristics and severity of influenza infections by virus type, subtype, and lineage: A systematic literature review

Clinical characteristics and severity of influenza infections by virus type, subtype, and lineage: A systematic literature review

TGF-β Blood Levels Distinguish Between Influenza A (H1N1)pdm09 Virus Sepsis and Sepsis due to Other Forms of Community-Acquired Pneumonia

Effect of low‐to‐moderate‐dose corticosteroids on mortality of hospitalized adolescents and adults with influenza A(H1N1)pdm09 viral pneumonia

Contact Info

Product

Resources

About