2011
DOI: 10.1111/j.1399-3062.2010.00551.x
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Influenza A (H1N1) virus‐induced hepatocellular injury in a kidney transplant patient

Abstract: The swine-origin influenza A (H1N1) virus is mainly responsible for flu. No hepatitis attributable to H1N1 virus has been previously documented. Herein, we report on a kidney transplant patient who developed influenza H1N1 virus-induced hepatocellular injury. The patient's body temperature was only somewhat elevated, and pulmonary and flu symptoms were mild. H1N1 virus was detected by polymerase chain reaction assay in nasopharyngeal and bronchoalveolar swabs, as well as in the serum. The hepatocellular injury… Show more

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Cited by 3 publications
(3 citation statements)
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References 4 publications
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“…8 Hepatitis or liver failure caused by influenza A virus has been recognized in patients with underlying cirrhosis, 9 children, 10 pregnant women, 11 and immunocompromised individuals such as renal and liver transplant recipients. 12,13 The degree of hepatic damage is proposed to be determined by the magnitude of CD8+ T-cell immune response and the interaction with pre-existing antibodies to influenza. Inadequate antibodies to counteract the influenza infection may trigger CD8+ T-cell response.…”
Section: Discussionmentioning
confidence: 99%
“…8 Hepatitis or liver failure caused by influenza A virus has been recognized in patients with underlying cirrhosis, 9 children, 10 pregnant women, 11 and immunocompromised individuals such as renal and liver transplant recipients. 12,13 The degree of hepatic damage is proposed to be determined by the magnitude of CD8+ T-cell immune response and the interaction with pre-existing antibodies to influenza. Inadequate antibodies to counteract the influenza infection may trigger CD8+ T-cell response.…”
Section: Discussionmentioning
confidence: 99%
“…Swine-origin influenza A virus-induced hepatocellular injury has been reported in a kidney transplant patient. 85…”
Section: Orf Virus (Poxvirus)mentioning
confidence: 99%
“…The current influenza virus vaccine does not protect against swine variant influenza viruses. Swine‐origin influenza A virus‐induced hepatocellular injury has been reported in a kidney transplant patient 85 . For transplant recipients who live on farms or are in any environment where pigs are being raised in large populations, providers should provide extensive strategies for safe living.…”
Section: Pigsmentioning
confidence: 99%