Influences of stress hormones on microbial infections

Sarkodie, Emmanuel Konadu; Zhou, Shuxin; Baidoo, Sarah Ama; Chu, Weihua

doi:10.1016/j.micpath.2019.04.013

Cited by 50 publications

(40 citation statements)

References 79 publications

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“…[64,65] Moreover, keratinocytes and melanocytes can be also local sources of catecholamines. [20,66] Nowadays, many bacterial species have been characterized for their response to catecholamines [67] but the effect of these neurohormones was rarely studied on bacteria isolated from the human skin. The unique study realized on the effect of adrenalin and noradrenalin on cutaneous bacterial strains was performed on C acnes using acneic (ribotype 4, RT4) and non-acneic strains (ribotype 6, RT6).…”

Section: Catecholaminesmentioning

confidence: 99%

Dialog between skin and its microbiota: Emergence of “Cutaneous Bacterial Endocrinology”

Racine

Janvier

Clabaut

et al. 2020

Experimental Dermatology

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The pioneering work of Kaplan and Greenberg [1] led to admit that, as eukaryotic cells, bacteria can communicate. In fact, many multicellular social bacterial behaviours such as swarming type motility, [2] biofilm formation [3] and virulence expression, [4] require population synchronization and that is performed at least partly through a highly regulated cell-to-cell communication system called quorum sensing (QS). QS is based on the bacterial population density, which is performed through secretion and sensing of specific signal molecules named autoinducers. Nowadays, many QS autoinducers, such as the N-acyl homoserine lactones (AHL) and quinolones (Gram-negative

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Section: Catecholaminesmentioning

confidence: 99%

Dialog between skin and its microbiota: Emergence of “Cutaneous Bacterial Endocrinology”

Racine

Janvier

Clabaut

et al. 2020

Experimental Dermatology

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“…Notwithstanding iatrogenic administration of antibiotics and gastric acid suppressants, the host's overall changes during critical illness promote the emergence of the pathobiome (disease‐related flora; Zaborin et al , ; Gilbert et al , ). This includes supranormal levels of catecholamines that induce pathogen growth, virulence, and biofilm formation, as well as directly impacting on the microbiome (Dickson et al , ; Sarkodie et al , ).…”

Section: Sepsis: a New Who Global Health Prioritymentioning

confidence: 99%

“…Numerous studies suggest that the relationship between the host and microbiome/pathobiome is bidirectional (Kelly et al , ; Sarkodie et al , ). Of note, gut‐specific bacteria can dominate the lung microbiome in septic patients, and this change correlates with alveolar TNF expression (Dickson et al , ).…”

Section: Sepsis: a New Who Global Health Prioritymentioning

confidence: 99%

Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

2020

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Sepsis has been identified by the World Health Organization (WHO) as a global health priority. There has been a tremendous effort to decipher underlying mechanisms responsible for organ failure and death, and to develop new treatments. Despite saving thousands of animals over the last three decades in multiple preclinical studies, no new effective drug has emerged that has clearly improved patient outcomes. In the present review, we analyze the reasons for this failure, focusing on the inclusion of inappropriate patients and the use of irrelevant animal models. We advocate against repeating the same mistakes and propose changes to the research paradigm. We discuss the long‐term consequences of surviving sepsis and, finally, list some putative approaches—both old and new—that could help save lives and improve survivorship.

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“…Several pathogens, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus improve their growth in the presence of norepinephrine (NE), primarily through increased iron acquisition [51]. Additionally, exposure to stress hormones may enhance the expression of those genes responsible for bacterial virulence [52]. Dietary components are metabolized by gut microbiota into molecules with hormone-like properties.…”

Section: Neurohormonesmentioning

confidence: 99%

The Gut Microbiota Affects Host Pathophysiology as an Endocrine Organ: A Focus on Cardiovascular Disease

2019

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It is widely recognized that the microorganisms inhabiting our gastrointestinal tract—the gut microbiota—deeply affect the pathophysiology of the host. Gut microbiota composition is mostly modulated by diet, and gut microorganisms communicate with the different organs and tissues of the human host by synthesizing hormones and regulating their release. Herein, we will provide an updated review on the most important classes of gut microbiota-derived hormones and their sensing by host receptors, critically discussing their impact on host physiology. Additionally, the debated interplay between microbial hormones and the development of cardiovascular disease will be thoroughly analysed and discussed.

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Influences of stress hormones on microbial infections

Cited by 50 publications

References 79 publications

Dialog between skin and its microbiota: Emergence of “Cutaneous Bacterial Endocrinology”

Dialog between skin and its microbiota: Emergence of “Cutaneous Bacterial Endocrinology”

Sepsis therapies: learning from 30 years of failure of translational research to propose new leads

The Gut Microbiota Affects Host Pathophysiology as an Endocrine Organ: A Focus on Cardiovascular Disease

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