Influences of negative BOLD responses on positive BOLD responses

Klingner, Carsten M.; Ebenau, Kerstin; Hasler, Caroline; Brodoehl, Stefan; Görlich, Yvonne; Witte, Otto W.

doi:10.1016/j.neuroimage.2011.01.028

Cited by 20 publications

(18 citation statements)

References 38 publications

(56 reference statements)

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“…The finding that different time courses exist for NBRs and PBRs gave rise to the hypothesis that these responses rely on two different mechanisms ( Hlushchuk and Hari, 2006;Klingner et al, 2011b). However, a recent study that investigated interactions between PBRs and NBRs did not support the hypothesis that these responses represent two superimposed, independent processes (Klingner et al, 2011a). In this study, it was demonstrated that an NBR could become interrupted at the onset of a PBR; however, this does not influence the amplitude or time course of the PBR.…”

Section: Origin Of the Nbrcontrasting

confidence: 59%

“…This finding was interpreted to indicate that the processes that mediate PBRs and NBRs are not parallel because, in the case of independent processes, both responses are expected to be superimposed. It has been further suggested that PBRs and NBRs engage in the same pathway of neurovascular coupling or at least that the pathways have some degree of interaction with each other (Klingner et al, 2011a).…”

Section: Origin Of the Nbrmentioning

confidence: 99%

“…nitric oxide) that are released by postsynaptic neurons may also play a role in this process (Koehler et al, 2009;Toda et al, 2009;Attwell et al, 2010). It has been hypothesized that decreased synaptic activity will decrease the amount of Ca 2+ in astrocytic endfeet, resulting in passive vasoconstriction and the NBR (Klingner et al, 2011a). A subsequent episode of neural excitation would then cause a largely undisturbed release of Ca 2+ .…”

Section: Origin Of the Nbrmentioning

confidence: 99%

“…A subsequent episode of neural excitation would then cause a largely undisturbed release of Ca 2+ . This hypothesis explains the time delay of the NBR, the fact that it becomes interrupted with the onset of a PBR, and the lack of influence that it has on both the amplitude and time course of a subsequent PBR (Klingner et al, 2011a). However, the mechanisms underlying the generation of NBRs are still incompletely understood, and it is conceivable that additional mechanisms (e.g.…”

Section: Origin Of the Nbrmentioning

confidence: 99%

“…Multiple studies in both animals and humans have found that NBRs can occur in the primary SI ipsilaterally to somatosensory stimulation (Hlushchuk and Hari, 2006;Devor et al, 2007;Kastrup et al, 2008;Boorman et al, 2010;Klingner et al, 2010Klingner et al, , 2011aKlingner et al, ,b, 2014Schafer et al, 2012;McGregor et al, 2014). Most studies in human subjects have employed the electrical stimulation of the median nerve (Kastrup et al, 2008;Klingner et al, 2010Klingner et al, , 2011aKlingner et al, ,b, 2014Schafer et al, 2012).…”

Section: Nbr In the Si And Their Functional Importancementioning

confidence: 99%

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The importance of the negative blood-oxygenation-level-dependent (BOLD) response in the somatosensory cortex

Klingner

Brodoehl

Witte

2015

Reviews in the Neurosciences

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AbstractIn recent years, multiple studies have shown task-induced negative blood-oxygenation-level-dependent responses (NBRs) in multiple brain regions in humans and animals. Converging evidence suggests that task-induced NBRs can be interpreted in terms of decreased neuronal activity. However, the vascular and metabolic dynamics and functional importance of the NBR are highly debated. Here, we review studies investigating the origin and functional importance of the NBR, with special attention to the somatosensory cortex.

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Section: Origin Of the Nbrcontrasting

confidence: 59%

Section: Origin Of the Nbrmentioning

confidence: 99%

Section: Origin Of the Nbrmentioning

confidence: 99%

Section: Origin Of the Nbrmentioning

confidence: 99%

Section: Nbr In the Si And Their Functional Importancementioning

confidence: 99%

See 3 more Smart Citations

The importance of the negative blood-oxygenation-level-dependent (BOLD) response in the somatosensory cortex

Klingner

Brodoehl

Witte

2015

Reviews in the Neurosciences

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Perceptual plasticity is mediated by connectivity changes of the medial thalamic nucleus

et al. 2012

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It is well known that the threshold for somatosensory perception may adapt to different inputs. Recent studies suggest the presence of a modulating effect of somatosensory inputs on the spinal dorsal horn. However, the effects of somatosensory inputs on cerebral processing and, in particular, on the functional and effective connectivity of the somatosensory brain network, are poorly understood. In this study, we investigated the longitudinal impact of somatosensory stimuli on the resting-state functional connectivity and effective connectivity of the somatosensory brain network. We performed resting-state functional magnetic resonance imaging (fMRI) in 12 healthy subjects before and after unilateral electrical median nerve stimulation. We combined this analysis with a psychophysiological examination of changes of the perception threshold. We found that the unilateral median nerve stimulation increased the perception thresholds bilaterally and increased the resting-state functional and effective connectivity between most cortical areas of the somatosensory network. The major finding, however, was a decreased resting-state functional connectivity between both secondary somatosensory cortices and the bilateral medial nuclear complex of the thalamus. This decreased connectivity was correlated with increased perception thresholds. These findings emphasize the importance of the medial thalamic nucleus for the perceptual awareness of somatosensory stimuli.

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Excitatory and inhibitory mechanisms underlying somatosensory habituation

Klingner¹,

Hasler²,

Brodoehl³

et al. 2012

Hum. Brain Mapp

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Habituation is a basic process of learning in which repeated exposure to a sensory stimulus leads to a decrease in the strength of neuronal activations and behavioral responses. In addition to increases in neuronal activity, sensory stimuli can also lead to decreases in neuronal activity. Until now, the effects of habituation on stimulus-induced neuronal deactivations have not been investigated. We performed functional magnetic resonance imaging in 30 healthy subjects during repetitive unilateral somatosensory stimulation and combined this analysis with a psychophysiological examination of changes in the perception threshold. Consistent with the literature, we found a time-dependent decrease of the positive blood oxygenation level-dependent (BOLD) response (indicative of habituation) in the primary somatosensory cortex (SI) contralateral to the stimulus. In contrast, the negative BOLD response (NBR) in the ipsilateral SI did not show a decrease in amplitude; instead, an increase in amplitude was found, i.e., a stronger NBR (increased response). The increased NBR was associated with an increased perception threshold of the nonstimulated hand. These findings suggest that habituation is not primarily characterized by a decrease in the neuronal response to repeated stimuli but rather a widespread change in the balance between excitatory and inhibitory effects that favors inhibitory effects.

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Influences of negative BOLD responses on positive BOLD responses

Cited by 20 publications

References 38 publications

The importance of the negative blood-oxygenation-level-dependent (BOLD) response in the somatosensory cortex

The importance of the negative blood-oxygenation-level-dependent (BOLD) response in the somatosensory cortex

Perceptual plasticity is mediated by connectivity changes of the medial thalamic nucleus

Excitatory and inhibitory mechanisms underlying somatosensory habituation

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