Influences of Folate Supplementation on Homocysteine and Cognition in Patients with Folate Deficiency and Cognitive Impairment

Hama, Yuka; Hamano, Tadanori; Shirafuji, Norimichi; Hayashi, Kouji; Ueno, Asako; Enomoto, Soichi; Nagata, Miwako; Kimura, Hirohiko; Matsunaga, Akiko; Ikawa, Masamichi; Yamamura, Osamu; Ito, Tatsuhiko; Kimura, Yuri; Kuriyama, Masaru; Nakamoto, Yasunari

doi:10.3390/nu12103138

Cited by 32 publications

(32 citation statements)

References 62 publications

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“…Notably, an association between homocysteine metabolism, oxidative stress and immune activation has been proven [ 34 ]. Low folate levels were also found to be associated with lower baseline MMSE scores in previous research [ 35 , 36 ].…”

Section: Discussionsupporting

confidence: 63%

Vitamin D and Folate as Predictors of MMSE in Alzheimer’s Disease: A Machine Learning Analysis

et al. 2021

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Vitamin D (VD) and micronutrients, including folic acid, are able to modulate both the innate and the adaptive immune responses. Low VD and folic acid levels appear to promote cognitive decline as in Alzheimer’s disease (AD). A machine learning approach was applied to analyze the impact of various compounds, drawn from the blood of AD patients, including VD and folic acid levels, on the Mini-Mental State Exam (MMSE) in a cohort of 108 patients with AD. The first analysis was aimed at predicting the MMSE at recruitment, whereas a second investigation sought to predict the MMSE after a 4 year follow-up. The simultaneous presence of low levels of VD and folic acid allow to predict MMSE, suggestive of poorer cognitive function. Such results suggest that the low levels of VD and folic acid could be associated with more severe cases of cognitive impairment in AD. It could be hypothesized that simultaneous supplementation of VD and folic acid could slow down the progression of cerebral degeneration at least in a subset of AD individuals.

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Section: Discussionsupporting

confidence: 63%

Vitamin D and Folate as Predictors of MMSE in Alzheimer’s Disease: A Machine Learning Analysis

et al. 2021

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“…Although this is a very small-scale study, a larger population-based study is needed to find any valid correlation between different B vitamins and hyperhomocysteinemia among AD and MCI patients. In patients with folate deficiency, cognitive impairment was ameliorated by folate supplementation for a short period [174]. Inflammation is one of the major factors that lead to progressive neurodegeneration in AD.…”

Section: Vitamins Based Clinical Studies In Alzheimer's Diseasementioning

confidence: 99%

The Role of Vitamins in Neurodegenerative Disease: An Update

et al. 2021

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Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson’s disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.

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“…Similar results were found by Yuka Hama et al, (2020) who administered folate in deficient patients. They found that reduced Hcy levels correlated with better scores in the mini-mental state examination (MMSE) [188].…”

Section: Vitamins (Deficit/supplement)mentioning

confidence: 99%

Targeting DNA Methylation in the Adult Brain through Diet

et al. 2021

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Metabolism and nutrition have a significant role in epigenetic modifications such as DNA methylation, which can influence gene expression. Recently, it has been suggested that bioactive nutrients and gut microbiota can alter DNA methylation in the central nervous system (CNS) through the gut–brain axis, playing a crucial role in modulating CNS functions and, finally, behavior. Here, we will focus on the effect of metabolic signals in shaping brain DNA methylation during adulthood. We will provide an overview of potential interactions among diet, gastrointestinal microbiome and epigenetic alterations on brain methylation and behavior. In addition, the impact of different diet challenges on cytosine methylation dynamics in the adult brain will be discussed. Finally, we will explore new ways to modulate DNA hydroxymethylation, which is particularly abundant in neural tissue, through diet.

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Influences of Folate Supplementation on Homocysteine and Cognition in Patients with Folate Deficiency and Cognitive Impairment

Cited by 32 publications

References 62 publications

Vitamin D and Folate as Predictors of MMSE in Alzheimer’s Disease: A Machine Learning Analysis

Vitamin D and Folate as Predictors of MMSE in Alzheimer’s Disease: A Machine Learning Analysis

The Role of Vitamins in Neurodegenerative Disease: An Update

Targeting DNA Methylation in the Adult Brain through Diet

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