Influences of dietary selenium, zinc and their combination on semen characteristics and testosterone concentration in mature rams during breeding season

Ghorbani, Ahad; Moeini, M. M.; Souri, M.; Hajarian, Hadi

doi:10.1080/09712119.2017.1406858

Cited by 19 publications

(14 citation statements)

References 31 publications

(45 reference statements)

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“…Similarly, Butt et al [132] demonstrated that Se (supplemented as 3g Selemax ® ) in combination with vitamin E significantly improved the ejaculate and sperm quality parameters, and increased the concentration of testosterone in Holstein Friesian bulls maintained in a hot and humid environment [132]. Additionally, Ghorbani et al [133] evaluated the effects of dietary Se (0.3 mg/kg), Zn (40 mg/kg) and their combination on reproductive performance in Sanjabi rams during the breeding season. They reported a significant improvement in sperm concentration, total sperm count, sperm motility following a 120 days long dietary supplementation.…”

Section: Role Of Selenium In Male Reproductionmentioning

confidence: 99%

“…They reported a significant improvement in sperm concentration, total sperm count, sperm motility following a 120 days long dietary supplementation. However, the concentration of testosterone remained unaltered [133]. In another randomized, double-blinded study, Kirchhoff and colleagues [134] failed to elucidate a clear trend in the extent to which a three months long supplementation of Se/vitamin E (tablets containing 0.1 mg organic Se; capsules containing 100 mg vitamin E) influences the semen qualitative traits in normospermic Cairn Terriers.…”

Section: Role Of Selenium In Male Reproductionmentioning

confidence: 99%

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Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

et al. 2019

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Selenium (Se) is an important trace mineral having many essential roles at the cellular and organismal levels in animal and human health. The biological effects of Se are mainly carried out by selenoproteins (encoded by 25 genes in humans and 24 in mice). As an essential component of selenoproteins, Se performs structural and enzymic roles; in the latter context it is well known for its catalytic and antioxidative functions. Studies involving different animal models have added great value to our understanding regarding the potential implications of Se and selenoproteins in mammalian fertility and reproduction. In this review, we highlight the implications of selenoproteins in male fertility and reproduction followed by the characteristic biological functions of Se and selenoproteins associated with overall male reproductive function. It is evident from observations of past studies (both animal and human) that Se is essentially required for spermatogenesis and male fertility, presumably because of its vital role in modulation of antioxidant defense mechanisms and other essential biological pathways and redox sensitive transcription factors. However, bearing in mind the evidences from mainstream literature, it is also advisable to perform more studies focusing on the elucidation of additional roles played by the peculiar and canonical selenoproteins i.e., glutathione peroxidase 4 (GPX4) and selenoprotein P (SELENOP) in the male reproductive functions. Nevertheless, search for the elucidation of additional putative mechanisms potentially modulated by other biologically relevant selenoproteins should also be included in the scope of future studies. However, as for the implication of Se in fertility and reproduction in men, though a few clinical trials explore the effects of Se supplementation on male fertility, due to inconsistencies in the recruitment of subjects and heterogeneity of designs, the comparison of such studies is still complicated and less clear. Therefore, further research focused on the roles of Se and selenoproteins is awaited for validating the evidences at hand and outlining any therapeutic schemes intended for improving male fertility. As such, new dimensions could be added to the subject of male fertility and Se supplementation.

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Section: Role Of Selenium In Male Reproductionmentioning

confidence: 99%

Section: Role Of Selenium In Male Reproductionmentioning

confidence: 99%

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

et al. 2019

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“…However, there was no increase in the number of living sperm. Similarly, authors [17] and [8] have not reported a significant influ ence on the number of living and dead sperm after supplementation with both organic and inorganic Se. On the contrary, other authors demonstrated increase of sperm viability after application of Se or combination of Se and vitamin E [7,12].…”

Section: Resultsmentioning

confidence: 91%

Effect of selenium on oxidative stress and viability of the ram spermatozoa during the spermatogenesis

Dolník¹,

Mudroňová²,

Lazăr³

et al. 2019

Bìol. Tvarin

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The aim of the experiment was to determine the effect of a single subcutaneous application of Selevit inj. on the volume and density of ejaculates, sperm viability, level of oxidative stress (OS) and apoptosis in semen by using flow cytometry. Ten rams were divided into two groups. The experimental group, (EG; n=6) was injected one time subcutaneously with the Selevit inj. at a dose of 5 ml per animal (11 mg of sodium selenite). The control group, (K; n=4) was subcutaneously administered with physiological solution at a dose of 5 ml per animal. Samples of blood and semen were collected from each ram prior to application of Se and at day one, 14, 26, 38, 50, 62 after selenium injection. Results showed, Se concentration in the blood of EG was significantly higher, but short-term. Se concentration in the semen of the EG was significantly higher during the whole duration of the experiment (62 days). The level of OS was significantly reduced at day one, 14 and 60 after application of Selevit injection. The number of dead spermatozoa was significantly lower in the EG only at day 14 and 26 after Se application. There was only a slight increase in the percentage of sperm in the early phase of apoptosis in EG. There were no significant differences in ejaculate volume and sperm concentration between groups. Single subcutaneous injection of Selevit is sufficient enough to maintain a significant long-term increase of Se concentration in semen and has a positive effect on the level of OS, but there was no substantial influence on the quality of ejaculates.

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“…The difference between the results of Piagentini et al(2017 ) and those obtained in our research can be contributed to different factors like the different climate (subtropical in their case, moderate in ours), breed differences or the way of semen collection (we use artificial vagina and they used electroejeculation). On the other hand there is a lot of data which shows that Se alone or in combination with Zn or vitamin E improves not only the morphology but also the sperm motility in rams (Kendall et al, 2000;Marai et al, 2009;Ghorbani et al, 2018). Moreover it was found that the injective application of selenium alone or in combination with vitamin E increase the sperm motility in bucks (El-Sheshtawy et al, 2014), andrams (Mahmoud et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…Lopez et al (2010) showed that addition of organic Se to the regular rations of boars lead to increased sperm concentration compared to inorganic Se but reduced some motility parameters and resistance to oxidative stress. Specifically in Sanjabi rams organic selenium (alone and in combinations with zinc) was recently reported to improve semen characteristics (Ghorbani et al, 2018). On the other hand inorganic selenium was found to decrease the percentage of sperm defects but without direct influence on ram sperm volume, total motility, concentration and membrane integrity in Brasil rams (Piagentini et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effect of supplementation with inorganic and organic selenium on sperm quality and quantity in north-east Bulgarian merino rams

Stefanov

Chervenkov

Anev³

et al. 2018

BIOTEC ANIM HUSB

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Selenium is a trace element, which stimulates antioxidant defenses and improves reproductive functions in human and animals, under the form of selenoproteins. The objective of the study was to evaluate the effect of selenium, supplemeted as inorganic or organic form in the diet of stud rams, on some of their semen parameters. The experiment was performed with 15 clinically healthy rams from North East Bulgarian merino breed. The animals were divided in three groups (5 per group). The rams from first experimental group (G1) received a diet with supplementation of 4,0mg sodium selenite (Na 2 SeO 3) per animal per day, while the animals of the second experimental group (G2) obtained diet with 1.83g L-selenomethionine (Sel-Plex, Alltech, USA) per animal per day. Eventually, each animal from the G1 and G2 received 1.83g selenium per day. The control group (GC) received a diet without supplementation of selenium. The principal composition of the diet in each group was the same. The ejaculates were obtained via artificial vagina. The evaluated parameters were volume and pH of the ejaculates and motility, concentration and in vitro survivability of the spermatozoa at 39˚С for 360 min. It was found that the supplementation of ram studs diet either with inorganic and organic selenium led to increase in the volume of the Rossen Stefanov et al. 70 ejaculates, motility and survivability of the spermatozoa. The pH of the freshly obtained semen was not affected by selenium treatment.

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Influences of dietary selenium, zinc and their combination on semen characteristics and testosterone concentration in mature rams during breeding season

Cited by 19 publications

References 31 publications

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

Effect of selenium on oxidative stress and viability of the ram spermatozoa during the spermatogenesis

Effect of supplementation with inorganic and organic selenium on sperm quality and quantity in north-east Bulgarian merino rams

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