Influence on elemental status by hip-endoprostheses

Zeiner, Michaela; Zenz, Peter; Lintner, Felix; Schuster, Ernst; Schwägerl, W; Steffan, Ilse

doi:10.1016/j.microc.2006.04.019

Cited by 10 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 116 In addition, deposition of Al in body fat and accumulation of Mo in lymph nodes were also confirmed in patients with THA. 124 …”

Section: Metabolism Profiles Of the Prosthetic Metalsmentioning

confidence: 99%

Prosthetic Metals: Release, Metabolism and Toxicity

Zhong,

Pan,

Chen

et al. 2024

IJN

View full text Add to dashboard Cite

The development of metallic joint prostheses has been ongoing for more than a century alongside advancements in hip and knee arthroplasty. Among the materials utilized, the Cobalt-Chromium-Molybdenum (Co-Cr-Mo) and Titanium-Aluminum-Vanadium (Ti-Al-V) alloys are predominant in joint prosthesis construction, predominantly due to their commendable biocompatibility, mechanical strength, and corrosion resistance. Nonetheless, over time, the physical wear, electrochemical corrosion, and inflammation induced by these alloys that occur post-implantation can cause the release of various metallic components. The released metals can then flow and metabolize in vivo, subsequently causing potential local or systemic harm. This review first details joint prosthesis development and acknowledges the release of prosthetic metals. Second, we outline the metallic concentration, biodistribution, and elimination pathways of the released prosthetic metals. Lastly, we discuss the possible organ, cellular, critical biomolecules, and significant signaling pathway toxicities and adverse effects that arise from exposure to these metals.

show abstract

“… 116 In addition, deposition of Al in body fat and accumulation of Mo in lymph nodes were also confirmed in patients with THA. 124 …”

Section: Metabolism Profiles Of the Prosthetic Metalsmentioning

confidence: 99%

Prosthetic Metals: Release, Metabolism and Toxicity

Zhong,

Pan,

Chen

et al. 2024

IJN

View full text Add to dashboard Cite

show abstract

“…Only one recent study investigated the concentration of titanium in human organs taken during a post mortem examination from subjects with a total hip replacement. 105 The orthopaedic devices were not made from Ti alloy, but rather CrCoMo alloy. Although there was 0.0005% of titanium, the concentration of metal was elevated only in the liver (in comparison with the control samples).…”

Section: Orthopaedic Implantsmentioning

confidence: 99%

Toxicological aspects of soluble titanium – a review of in vitro and in vivo studies

2016

View full text Add to dashboard Cite

Owing to the widespread use of titanium dioxide (TiO) in various food, household and cosmetic products and in industry, the number of publications concerned with the potential toxic effects and health risks related to this substance in both bulk and nano form is steadily increasing. On the other hand, there is also a third form of titanium, ionic, which is produced by the biodegradation of Ti alloy implants. Thus, the growing population of implant recipients should raise concerns about the impact of soluble Ti on human health. Today, the mechanism of this metal's action on the human body is still not fully understood. This review aims to explore the health risks associated especially with long-term use of titanium implants. The paper provides an analysis of data available from the last 10 years concerning investigations of the adverse effects of Ti ions, including in vitro models of various tissues, in vivo studies of implant corrosion in animals and humans, and potential pathomechanisms of the adverse health impact induced by soluble titanium.

show abstract

“…It is important that reported data are obtained using procedures for sample collection, preparation and measurement that are adequately validated so that results from different investigations can be usefully compared. Zeiner et al 136 developed a suitable procedure for reporting concentrations of Al, Co, Cr, Mo, Nb, Ni and Ti in nine different tissues. Their results indicated accumulation in brain and lung with increases in Mo and Nb being most marked.…”

Section: Tissuesmentioning

confidence: 99%