Influence of various acute stressors on the activity of adult male rats in a holeboard and in the forced swim test

Armario, Antonio; Gil, Montserrat; Martí, Joaquín; Pol, Olga; Balasch, Juan

doi:10.1016/0091-3057(91)90194-7

Cited by 103 publications

(50 citation statements)

References 40 publications

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“…reduced swimming behaviors in the forced swimming test and increased immobility time in the tail suspension test) as compared to the control group, similar to mice treated with a typical depression-inducing stressor [15]. However, as mentioned above, "antidepressant" effects for NC have also been reported clinically [11], and were also observed in some animal models [43-45].…”

Section: Discussionmentioning

confidence: 83%

“…The protocols for the NC and stressor treatments were determined based on preliminary experiments and previous studies examining their behavioral effects [9,10,15,16]. With respect to the NC treatment, repeated subcutaneous (s.c.) doses of NC which caused the depression-like behaviors most effectively were selected: a single s.c. dose of 0.3 mg/kg was administered daily for 4 days [9,10].…”

Section: Methodsmentioning

confidence: 99%

“…This test is used for screening antidepressants, which suppress immobility in swimming behaviors [14]. On the other hand, various stressors such as immobilization stress (IM) are known to cause depression-like behaviors, as represented by exacerbated immobility in swimming behaviors [15,16]. Repeated NC administration also caused exacerbated immobility in these behavioral tests [9,10,13].…”

Section: Introductionmentioning

confidence: 99%

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Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors

Hayase

2011

BMC Pharmacol

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BackgroundThe contributions of brain cannabinoid (CB) receptors, typically CB1 (CB type 1) receptors, to the behavioral effects of nicotine (NC) have been reported to involve brain transient receptor potential vanilloid 1 (TRPV1) receptors, and the activation of candidate endogenous TRPV1 ligands is expected to be therapeutically effective. In the present study, the effects of TRPV1 ligands with or without affinity for CB1 receptors were examined on NC-induced depression-like behavioral alterations in a mouse model in order to elucidate the "antidepressant-like" contributions of TRPV1 receptors against the NC-induced "depression" observed in various types of tobacco abuse.ResultsRepeated subcutaneous NC treatments (NC group: 0.3 mg/kg, 4 days), like repeated immobilization stress (IM) (IM group: 10 min, 4 days), caused depression-like behavioral alterations in both the forced swimming (reduced swimming behaviors) and the tail suspension (increased immobility times) tests, at the 2 h time point after the last treatment. In both NC and IM groups, the TRPV1 agonists capsaicin (CP) and olvanil (OL) administered intraperitoneally provided significant antidepressant-like attenuation against these behavioral alterations, whereas the TRPV1 antagonist capsazepine (CZ) did not attenuate any depression-like behaviors. Furthermore, the endogenous TRPV1-agonistic CB1 agonists anandamide (AEA) and N-arachidonyldopamine (NADA) did not have any antidepressant-like effects. Nevertheless, a synthetic "hybrid" agonist of CB1 and TRPV1 receptors, arvanil (AR), caused significant antidepressant-like effects. The antidepressant-like effects of CP and OL were antagonized by the TRPV1 antagonist CZ. However, the antidepressant-like effects of AR were not antagonized by either CZ or the CB1 antagonist AM 251 (AM).ConclusionsThe antidepressant-like effects of TRPV1 agonists shown in the present study suggest a characteristic involvement of TRPV1 receptors in NC-induced depression-like behaviors, similar to those caused by IM. The strong antidepressant-like effects of the potent TRPV1 plus CB1 agonist AR, which has been reported to cause part of its TRPV1-mimetic and cannabimimetic effects presumably via non-TRPV1 or non-CB1 mechanisms support a contribution from other sites of action which may play a therapeutically important role in the treatment of NC abuse.

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Section: Discussionmentioning

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors

Hayase

2011

BMC Pharmacol

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“…Immobility time was defined as the summed time during which animals remained floating with all limbs motionless. This scoring method has been described previously (Porsolt et al 1977a;Armario et al 1988Armario et al , 1991Kim and Han 2006).…”

Section: Forced Swim Test (Fst)mentioning

confidence: 99%

Antidepressant-like effect of chlorogenic acid isolated fromArtemisia capillarisThunb.

Park

Sim

Han

et al. 2010

Animal Cells and Systems

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Artemisia capillaris Thunb. is widely used in the herbal medicine field. This study describes the antidepressant effect of a flavonoid (chlorogenic acid) isolated from the Artemisia capillaris Thunb. The expression of the pituitary gland and hypothalamic POMC mRNA or plasma b-endorphin levels were increased by extract of Artemisia capillaris Thunb. or its flavoniod administered orally. In addition, antidepressant activity was studied using the tail suspension test (TST), the forced swimming test (FST) and the rotarod test in a chronically restrained immobilization stress group in mice. After restraint stress (2 h/day for 14 days), animals were kept in a cage for 14 days without any further stress, but with drugs. Mice were fed with a diet supplemented for 14 days and during the behavioral test period with chlorogenic acid (30 mg/kg/day). POMC mRNA or the plasma b-endorphin level was increased by the extract of Artemisia capillaris Thunb. and its flavoniod. In addition, the immobility time in TST and FST was significantly reduced by chlorogenic acid. In the rotarod test, the riding time remained similar to that of the control group at 15 rpm. Our results suggest that the flavonoid (chlorogenic acid) isolated from Artemisia capillaris Thunb. shows a potent antidepressant effect.

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“…Blood serum was prepared from the blood samples and analyzed for corticosterone levels. A review of the literature had indicated that 30 minutes of noise at the level we were using should induce a rise in corticosterone levels in rats (Ovadia et al, 2001;Amario et al, 1991;Britton et al, 1992;Campeau and Watson, 1997),. A study by Nolan et al, 1977 of diurnal variation of corticosterone in female Wistar rats showed that levels of the stress hormone were low in the first 6 hours of the light cycle and rose to a peak that occurs just prior to the onset of the dark cycle.…”

Section: Corticosterone Studiesmentioning

confidence: 99%

Low Level Chemical Toxicity: Relevance to Chemical Agent Defense

Morris¹

2003

PsycEXTRA Dataset

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Influence of various acute stressors on the activity of adult male rats in a holeboard and in the forced swim test

Cited by 103 publications

References 40 publications

Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors

Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors

Antidepressant-like effect of chlorogenic acid isolated fromArtemisia capillarisThunb.

Low Level Chemical Toxicity: Relevance to Chemical Agent Defense

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