Influence of vaccine strains on the evolution of canine distemper virus

Budaszewski, Renata da Fontoura; Streck, André Felipe; Weber, Matheus Nunes; Siqueira, Franciele Maboni; Guedes, Rafael Lucas Muniz; Canal, Cláudio Wageck

doi:10.1016/j.meegid.2016.04.014

Cited by 24 publications

(23 citation statements)

References 54 publications

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“…Due to its genetic variability, the H gene has been used for determining CDV genetic lineages which are related within the geographic origin that the lineages were detected. Currently, there are at least seventeen major CDV genetic lineages, including the America-1 to -5, Europe Wildlife, Arctic, South Africa, America-1/Europe, South America-1 to -3, Rockborn-like, Asia-1 to -3 5–8 and a novel CDV lineage, Asia-4, that was recently reported in Thailand 9 , and subsequently in China 10 and Russia 11 . However, because of its genetic variability, both intra- and inter-genetic recombination among lineages have frequently been reported in highly variable regions 5,12–20 .…”

Section: Introductionmentioning

confidence: 99%

“…Genetic recombination events are well documented among the paramyxoviruses, particularly in Measles virus (MV), Newcastle disease virus (NDV) and Respiratory syncytial virus (RSV) 17,18,22,23 . For CDV, recent studies on the previously available CDV genomes in GenBank database indicated the recombination events of the CDVs that were discovered since late 1998 5,14,20 . These studies showed that recombination occurred in various regions of CDV genome, particularly in the H gene.…”

Section: Introductionmentioning

confidence: 99%

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Genetic and evolutionary analysis of a new Asia-4 lineage and naturally recombinant canine distemper virus strains from Thailand

Piewbang

Radtanakatikanon

Puenpa

et al. 2019

Sci Rep

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Canine distemper virus (CDV), a pathogen causing fatal disease in a wide range of carnivores, can be classified into several geographically-related lineages. It is unclear how genetic recombination contributed to the evolution and emergence of the novel CDV strains and the evolutions of these strains are not fully yet investigated. In this study, the complete genome sequences of eight CDV viruses, isolated from domestic dogs in Thailand, were investigated. Interestingly, most of the identified CDV strains (CDV1-3, -5, -8 TH/2014) clustered as a novel Asia-4 lineage, while the CDV4, -6, -7 TH/2014 belonged to the Asia-1 lineage. Recombination analysis revealed that the CDV4 TH/2014 is a putative recombinant virus from the Asia-1 and America-2 parent viruses. In contrast, no recombination events were detected in the Asia-4 lineage, indicating that it is a distinctive lineage. Evolutionary analysis suggested that the CDV Asia-4 lineage had emerged since 1924 and shared common ancestor with the America-2 lineage. Pressure analysis revealed that CDV nucleotides were under negative selection pressure for its rapid adaptation. These findings demonstrate the evolution of CDV Asia-4 lineage and identified the Asia-1 recombination event. The information regarding genetic diversity of CDVs is essential for further CDV’s research and monitoring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic and evolutionary analysis of a new Asia-4 lineage and naturally recombinant canine distemper virus strains from Thailand

Piewbang

Radtanakatikanon

Puenpa

et al. 2019

Sci Rep

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“…Recombination analyses detected 16 unique putative recombination events in 11 sequences ( Table 2 ) from 119 CDV WGS analyzed. Nine of these putatively recombinant sequences have been described elsewhere [ 33 , 34 , 35 , 36 ]. Five recombination events were detected in a single raccoon dog ( Nyctereutes procyonoides , Canidae) genome sampled in China in 2013 (GenBank Accession KJ994343).…”

Section: Resultsmentioning

confidence: 99%

Identifying Candidate Genetic Markers of CDV Cross-Species Pathogenicity in African Lions

et al. 2020

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Canine distemper virus (CDV) is a multi-host pathogen with variable clinical outcomes of infection across and within species. We used whole-genome sequencing (WGS) to search for viral markers correlated with clinical distemper in African lions. To identify candidate markers, we first documented single-nucleotide polymorphisms (SNPs) differentiating CDV strains associated with different clinical outcomes in lions in East Africa. We then conducted evolutionary analyses on WGS from all global CDV lineages to identify loci subject to selection. SNPs that both differentiated East African strains and were under selection were mapped to a phylogenetic tree representing global CDV diversity to assess if candidate markers correlated with documented outbreaks of clinical distemper in lions (n = 3). Of 54 SNPs differentiating East African strains, ten were under positive or episodic diversifying selection and 20 occurred in the clinical strain despite strong purifying selection at those loci. Candidate markers were in functional domains of the RNP complex (n = 19), the matrix protein (n = 4), on CDV glycoproteins (n = 5), and on the V protein (n = 1). We found mutations at two loci in common between sequences from three CDV outbreaks of clinical distemper in African lions; one in the signaling lymphocytic activation molecule receptor (SLAM)-binding region of the hemagglutinin protein and another in the catalytic center of phosphodiester bond formation on the large polymerase protein. These results suggest convergent evolution at these sites may have a functional role in clinical distemper outbreaks in African lions and uncover potential novel barriers to pathogenicity in this species.

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“…Furthermore, there are growing concerns about the impact of CDV infection because of its recurrent outbreaks, conservation threat to wildlife, economic impact, the emergence of vaccine-escaping strains, host-switching events, and potential risk for humans [7, 8, 25]. Therefore, the discovery of antiviral drugs able to effectively control CDV is an urgent need.…”

Section: Discussionmentioning

confidence: 99%

“…Mutations in the H gene might be associated with antigenic divergence between field strains, current vaccine viruses [6], and host-switching events [7]. Antigenic drift and the absence of a specific treatment may hamper effective control and eradication of CDV [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

6-methylmercaptopurine riboside, a thiopurine nucleoside with antiviral activity against canine distemper virus in vitro

Carvalho

Félix

Tozato

et al. 2017

Virol J

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BackgroundCanine distemper (CD) is a widespread infectious disease that can severely impact a variety of species in the order Carnivora, as well as non-carnivore species such as non-human primates. Despite large-scale vaccination campaigns, several fatal outbreaks have been reported in wild and domestic carnivore populations. This, in association with expansion of the disease host range and the development of vaccine-escape strains, has contributed to an increased demand for therapeutic strategies synergizing with vaccine programs for effectively controlling canine distemper. 6-methylmercaptopurine riboside (6MMPr) is a modified thiopurine nucleoside with known antiviral properties against certain RNA viruses.MethodsWe tested the inhibitory effects of 6MMPr against a wild-type CDV strain infection in cell culture. We measured infectious particle production and viral RNA levels in treated and untreated CDV-infected cells. Ribavirin (RIB) was used as a positive control.ResultsHere, we report for the first time the antiviral effects of 6MMPr against canine distemper virus (CDV) in vitro. 6MMPr was able to reduce viral RNA levels and to inhibit the production of infectious CDV particles. The therapeutic selectivity of 6MMPr was approximately six times higher than that of ribavirin.ConclusionOur results indicate that 6MMPr has high anti-CDV potential and warrants further testing against other paramyxoviruses, as well as clinical testing of the compound against CDV.

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Influence of vaccine strains on the evolution of canine distemper virus

Cited by 24 publications

References 54 publications

Genetic and evolutionary analysis of a new Asia-4 lineage and naturally recombinant canine distemper virus strains from Thailand

Genetic and evolutionary analysis of a new Asia-4 lineage and naturally recombinant canine distemper virus strains from Thailand

Identifying Candidate Genetic Markers of CDV Cross-Species Pathogenicity in African Lions

6-methylmercaptopurine riboside, a thiopurine nucleoside with antiviral activity against canine distemper virus in vitro

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