Influence of treadmill training on bone structure under osteometabolic alteration in rats subjected to high‐fat diet

Macedo, Ana Paula; Shimano, Roberta Carminati; Ferrari, D. T.; Issa, João Paulo Mardegan; Jordão, Alceu Afonso; Shimano, Antonio Carlos

doi:10.1111/sms.12650

Cited by 14 publications

(25 citation statements)

References 38 publications

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“…In the present study, all animals increased body mass during the experiment. However, the ovariectomized groups showed higher gain when compared to sham animals, corroborating with some authors who also studied ovariectomized rats …”

Section: Discussionsupporting

confidence: 90%

“…After ovariectomy, one of the factors that can be changed is body mass gain . In the present study, all animals increased body mass during the experiment.…”

Section: Discussionmentioning

confidence: 44%

“…To induce osteopenia, ovariectomy was performed, which is a model widely used to study osteometabolic diseases . The literature indicates that after ovariectomy, osteopenia is present within a month .…”

Section: Discussionmentioning

confidence: 99%

“…To induce osteopenia, ovariectomy was performed, which is a model widely used to study osteometabolic diseases. 3,15 The literature indicates that after ovariectomy, osteopenia is present within a month. 15 The experiment started with the animals having a weight between 150 and 180 g, with the animals clearly classified as young.…”

Section: Discussionmentioning

confidence: 99%

“…Balanced nutrition is fundamental to maintaining overall health, especially in postmenopausal women. Unbalanced nutrition is a risk factor for the development of diseases prevalent in this phase of life …”

Section: Introductionmentioning

confidence: 99%

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Effects of high‐impact exercise on the physical properties of bones of ovariectomized rats fed to a high‐protein diet

Shimano

Yanagihara

Macedo

et al. 2018

Scandinavian Med Sci Sports

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The aim of this study was to evaluate the effects of high-impact physical exercise as a prophylactic and therapeutic means in osteopenic bones of rats submitted to ovariectomy and protein diet intake. A total of 64 Wistar rats were divided into eight groups (n = 8 each), being: OVX, ovx, standard diet and sedentary; OVXE, ovx, standard diet and jump; OVXP, ovx, high-protein diet and sedentary; and OVXEP, ovx, high-protein diet and jump; SH, sham, standard diet and sedentary; SHE, sham, standard diet and jump; SHP, sham, high-protein diet and sedentary; and SHEP, sham, high-protein diet and jump. OVX surgery consists of ovariectomy, and sham was the control surgery. The jumping protocol consisted of 20 jumps/day, 5 days/week. The bone structure was evaluated by densitometry, mechanical tests, histomorphometric, and immunohistochemical analyses. A high-protein diet resulted in increased bone mineral density (P = .049), but decreased maximal load (P = .026) and bone volume fraction (P = .023). The benefits of physical exercise were demonstrated by higher values of the maximal load in the trained groups compared to the sedentary groups (P < .001). The sham groups had decreased immunostaining of osteocalcin (P = .004) and osteopontin (P = .010) compared to ovx groups. However, the high-protein diet (P = .005) and jump exercise (P = .017) resulted in lower immunostaining of osteopontin compared to the standard diet and sedentary groups, respectively. In this experimental model, it was concluded that ovariectomy and a high-fat diet can negatively affect bone tissue and the high-impact exercise was not enough to suppress the deleterious effects caused by the protein diet and ovariectomy.

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Section: Discussionsupporting

confidence: 90%

“…After ovariectomy, one of the factors that can be changed is body mass gain . In the present study, all animals increased body mass during the experiment.…”

Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of high‐impact exercise on the physical properties of bones of ovariectomized rats fed to a high‐protein diet

Shimano

Yanagihara

Macedo

et al. 2018

Scandinavian Med Sci Sports

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A high-fat diet can affect bone healing in growing rats

et al. 2017

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A high-fat diet (HFD) can have a negative effect on bone quality in young and old people. Although bone healing in children is normally efficient, there is no evidence that children who have a diet rich in fat have compromised bone fracture regeneration compared with children with recommended dietary fat levels. The purpose of the present study was to evaluate the effects of an HFD on bone healing in growing female rats. Twenty-six postweaning female Wistar rats were divided into two groups (13 animals per group): a standard diet (SD) group and an HFD (with 60% of energy from fat) group. The rats received the assigned diets for 5 weeks, and in the third week they were submitted to an osteotomy procedure of the left tibia. Body mass and feed intake were recorded during the experiment. One day before euthanasia, an insulin tolerance test was performed. After euthanasia, the tibiae were removed and analyzed by densitometry, mechanical testing, histomorphometry, stereology and immunohistochemistry. An HFD caused an adaptive response to maintain energetic balance by decreasing feed intake and causing insulin insensitivity. There was no change in bone mineral density, collagen amount and immunostaining for bone formation, but maximal load and stiffness were decreased in the HFD group. In addition, bone volume had a tendency to be higher in the SD group than in the HFD group. Compared with rats receiving an SD, growing rats receiving an HFD for 5 weeks had similar bone mineral density but altered mechanical properties at the osteotomy defect site.

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Treadmill exercise promotes bone tissue recovery in rats subjected to high + Gz loads

Gao,

Chen,

Lin

et al. 2024

J Bone Miner Metab

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Influence of treadmill training on bone structure under osteometabolic alteration in rats subjected to high‐fat diet

Cited by 14 publications

References 38 publications

Effects of high‐impact exercise on the physical properties of bones of ovariectomized rats fed to a high‐protein diet

Effects of high‐impact exercise on the physical properties of bones of ovariectomized rats fed to a high‐protein diet

A high-fat diet can affect bone healing in growing rats

Treadmill exercise promotes bone tissue recovery in rats subjected to high + Gz loads

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