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“…Two previous meta-analyses of the included studies were focused on the application of tranexamic acid in ICH patients, but not on early administration, which was quite different from the aims of our study. They obtained the same conclusion that the treatment with tranexamic acid did not improve the mortality and the poor functional outcomes but significantly decreased the growth of the hemorrhagic mass in ICH patients, reducing the clinical value of its widespread use (27,28). However, a meta-analysis confirmed that tranexamic acid significantly diminished the death caused by acute severe bleeding (26).…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Two previous meta-analyses of the included studies were focused on the application of tranexamic acid in ICH patients, but not on early administration, which was quite different from the aims of our study. They obtained the same conclusion that the treatment with tranexamic acid did not improve the mortality and the poor functional outcomes but significantly decreased the growth of the hemorrhagic mass in ICH patients, reducing the clinical value of its widespread use (27,28). However, a meta-analysis confirmed that tranexamic acid significantly diminished the death caused by acute severe bleeding (26).…”
Section: Discussionmentioning
“…Concerning patients with brain injury, no trials exist that convincingly demonstrated that TXA reduces brain bleeding. A systematic review showed that TXA after brain injury likely has no effect on mortality or disability [74][75][76]. This finding was supported by a randomized clinical trial, that included 1,603 patients randomized over two different TXA dosing regimens and placebo, showing that TXA does not improve neurologic outcome at 6 months in patients with moderate to severe traumatic brain injury [77].…”
Section: Traumamentioning
“…The only outcome for which TXA might be beneficial is growth of the hemorrhagic mass. Multiple studies indicated that TXA, in the same dose as in CRASH-2, reduces intracranial hemorrhage progression compared to placebo-treated patients [75,76,[79][80][81]. The clinical relevance of this finding, however, is unclear, given the negative results of the aforementioned studies [74][75][76][77].…”
Section: Traumamentioning
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“…38 In a metaanalysis of the use of tranexamic acid in patients with cerebral hemorrhage, tranexamic acid use was not associated with a change in mortality or need for surgical intervention. 39 Given the lack of mortality reduction associated with its use, the utility and effectiveness of tranexamic acid in the ED bloodless medicine population remains unclear.…”
Section: Hereby Consent To Everything I Have Accepted On This Formmentioning