Influence of Total Intravenous Anesthesia, Entropy and Laparoscopy on Oxidative Stress

Nunes, Rogean Rodrigues; Nora, Fernando Squeff; Dumaresq, Danielle Maia Holanda; Cavalcante, Rute Maria Araújo; Costa, Antonio; Carneiro, Lara Moreira Mendes; Alencar, Júlio César Garcia de; Cardoso, Flávia Pereira Fernandes

doi:10.1016/s0034-7094(12)70147-2

Cited by 11 publications

(9 citation statements)

References 43 publications

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“…In regard to the anesthetic management, recovery times were significantly shorter for the group where Entropy levels were kept between 45 and 59 (7.70 ± 1.24 min vs. 10.20 ± 0.90 min, P < 0.05). The increase in redox imbalance markers for the patients that received a deeper hypnosis (Entropy 20-44) reveals an increase in anaerobic metabolism, possibly because of an accentuated suppression of the autonomic nervous system [92].…”

Section: The Impact On Inflammation/redoxmentioning

confidence: 97%

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Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance During General Anesthesia - A New Era in Patient Safety Standards and Healthcare Management

Rogobete¹,

Bedreag²,

Păpurică³

et al. 2020

Preprint

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Worldwide, an increasing number of patients undergo complex surgeries. With the development of general anesthesia techniques and anesthetic substances, the most complex surgical techniques could be developed. In order to adapt the anesthesia according to the particularities of each patient, it is recommended the multimodal monitoring of these patients. Classically, general anesthesia monitoring consists of the analysis of vital functions and gas exchange. Multimodal monitoring refers to the concomitant monitoring of the degree of hypnosis and the nociceptive-antinociceptive balance. By titrating anesthetic drugs according to these parameters, clinical benefits can be obtained, such as hemodynamic stabilization, reduction of awakening times, reduction of post-operative complications. Also, there is an important impact on the status of inflammation and the redox balance. The purpose of this literature review is to present the most modern multimodal monitoring techniques, respectively to discuss the particularities of each technique.

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Section: The Impact On Inflammation/redoxmentioning

confidence: 97%

“…Under surgical stress, in the case of ischemia-reperfusion syndrome or hypotension an excessive amount of free radicals will be produced, as well as pro-inflammatory mediators. All these factors will also decrease the production capacity for antioxidant molecules [92].…”

Section: The Impact On Inflammation/redoxmentioning

confidence: 99%

Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance During General Anesthesia - A New Era in Patient Safety Standards and Healthcare Management

Rogobete¹,

Bedreag²,

Păpurică³

et al. 2020

Preprint

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“…Under physiological conditions, P a O 2 = 80–100 mmHg. When P a O 2 exceeds 100 mmHg, the patient is characterized by hyperoxia, the most important systemic effect being the increased and accelerated production of reactive oxygen species (ROS) and the development of oxidative stress (OS) [ 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. The most important mechanisms through which OS is augmented in the case of general anesthesia are represented by the increase in molecular oxygen offerings at the mitochondria, the interaction with reactive nitrogen species (RNS), and lipid peroxidation with destruction of cellular membranes [ 25 , 100 , 101 , 102 , 103 ] ( Figure 2 ).…”

Section: The Impact Of General Anesthesia Multimodal Monitoring Onmentioning

confidence: 99%

Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance during General Anesthesia—A New Era in Patient Safety Standards and Healthcare Management

et al. 2021

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The development of general anesthesia techniques and anesthetic substances has opened new horizons for the expansion and improvement of surgical techniques. Nevertheless, more complex surgical procedures have brought a higher complexity and longer duration for general anesthesia, which has led to a series of adverse events such as hemodynamic instability, under- or overdosage of anesthetic drugs, and an increased number of post-anesthetic events. In order to adapt the anesthesia according to the particularities of each patient, the multimodal monitoring of these patients is highly recommended. Classically, general anesthesia monitoring consists of the analysis of vital functions and gas exchange. Multimodal monitoring refers to the concomitant monitoring of the degree of hypnosis and the nociceptive-antinociceptive balance. By titrating anesthetic drugs according to these parameters, clinical benefits can be obtained, such as hemodynamic stabilization, the reduction of awakening times, and the reduction of postoperative complications. Another important aspect is the impact on the status of inflammation and the redox balance. By minimizing inflammatory and oxidative impact, a faster recovery can be achieved that increases patient safety. The purpose of this literature review is to present the most modern multimodal monitoring techniques to discuss the particularities of each technique.

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“…It is known that according to injury of these radicals to the cell membrane, tissue integrity is damaged and the antioxidant capacity of the organism is reduced [1][2][3]. The laparoscopic procedures with possible I/R injury and major abdominal surgery especially accompanying sepsis, serious trauma are very important acute inflammation cascades and they require meticulous management of anesthesia [4].…”

Section: Introductionmentioning

confidence: 99%

The effects of Dexmedetomidine on oxidant - antioxidant systems in the experimental model of carbondioxide pneumoperitoneum

Taş¹

2014

Turk J Bioch

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Objective: The aim of the study was to investigate the changes of oxidative and anti-oxidative systems in the splanchnic area during carbon dioxide pneumoperitoneum and to determine whether the administration of dexmedetomidine has effects on these systems. Methods: Forty rats were randomized into four groups: Group I; Control, Group II; No pneumoperitoneum, Dexmedetomidine administration, Group III; Pneumoperitoneum, no Dexmedetomidine administration and Group IV; Pneumoperitoneum and Dexmedetomidine administration 30 minutes before insufflation. The rats were rested 30 minutes after desufflation and blood samples were obtained for; ischaemia modified albumin (IMA), myeloperoxidase (MPO), advanced oxidation protein products (AOPP), catalase (CAT), paraoxonase (PON1) and platelet-activating factor acetylhydrolase (PAF-AH) analyses. Results: When compared with the control group; the serum IMA levels significantly decreased in group II, and also increased in group III as compared to control (p<0.05). IMA levels were also significantly decreased in both groups II and IV as compared to group III (p<0.001). Serum MPO activity increased in group III as compared to control (p<0.05). Serum AOPP levels were significantly increased in group III as compared to group II (p<0.01) and decreased in group IV as compared to group III (p<0.01). Serum CAT activity was higher in group II than controls (p<0.05). Serum PON and plasma PAF-AH activities significantly decreased in grup III as compared to group II (p<0.05) and plasma PAF-AH activity were decreased in group III as compared to controls (p<0.05). Conclusion:In conclusion, administration of dexmedetomidine; prior to ischemia reperfusion injury caused by pneumoperitoneum; reduces the oxidative injury and increases the antioxidant activity in the acute period.

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Influence of Total Intravenous Anesthesia, Entropy and Laparoscopy on Oxidative Stress

Cited by 11 publications

References 43 publications

Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance During General Anesthesia - A New Era in Patient Safety Standards and Healthcare Management

Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance During General Anesthesia - A New Era in Patient Safety Standards and Healthcare Management

Multiparametric Monitoring of Hypnosis and Nociception-Antinociception Balance during General Anesthesia—A New Era in Patient Safety Standards and Healthcare Management

The effects of Dexmedetomidine on oxidant - antioxidant systems in the experimental model of carbondioxide pneumoperitoneum

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