Influence of time, temperature and solvent on the extraction of bioactive compounds of Baccharis dracunculifolia: In vitro antioxidant activity, antimicrobial potential, and phenolic compound quantification

Casagrande, Maira; Zanela, Juliano; Júnior, Américo Wagner; Busso, Cleverson; Wouk, Jéssica; Iurckevicz, Genice; Montanher, Paula Fernandes; Yamashita, Fábio; Malfatti, Carlos Ricardo Maneck

doi:10.1016/j.indcrop.2018.08.088

Cited by 63 publications

(48 citation statements)

References 66 publications

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“…Živković et al [ 57 ] found that the maximum recovery of polyphenols from Gentiana lutea root was reached at the highest temperature studied (80 °C). In another study, Casagrande et al [ 58 ] corroborated that an increase in temperature from 40 to 80 °C improved the extraction of phenolic compounds by 50%.…”

Section: Resultsmentioning

confidence: 89%

Valorisation of Exhausted Olive Pomace by an Eco-Friendly Solvent Extraction Process of Natural Antioxidants

et al. 2020

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Exhausted olive pomace (EOP) is the waste generated from the drying and subsequent extraction of residual oil from the olive pomace. In this work, the effect of different aqueous solvents on the recovery of antioxidant compounds from this lignocellulosic biomass was assessed. Water extraction was selected as the best option for recovering bioactive compounds from EOP, and the influence of the main operational parameters involved in the extraction was evaluated by response surface methodology. Aqueous extraction of EOP under optimised conditions (10% solids, 85 ºC, and 90 min) yielded an extract with concentrations (per g EOP) of phenolic compounds and flavonoids of 44.5 mg gallic acid equivalent and 114.9 mg rutin equivalent, respectively. Hydroxytyrosol was identified as the major phenolic compound in EOP aqueous extracts. Moreover, these extracts showed high antioxidant activity, as well as moderate bactericidal action against some food-borne pathogens. In general, these results indicate the great potential of EOP as a source of bioactive compounds, with potential uses in several industrial applications.

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Section: Resultsmentioning

confidence: 89%

Valorisation of Exhausted Olive Pomace by an Eco-Friendly Solvent Extraction Process of Natural Antioxidants

et al. 2020

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“…Recentemente, Casagrande et al, 24 ao investigarem a influência da temperatura de extração no conteúdo fenólico total em alecrim do campo, observaram que ao aumentar a temperatura de extração de 40 Figura 2. Gráficos de superfície de resposta para conteúdo fenólico total em função de: Temperatura de secagem versus Temperatura de infusão (A); Temperatura de secagem versus Tempo (B); Temperatura de infusão versus Tempo (C) para 80 °C resultou em um aumento de 50% no CFT.…”

Section: Otimização Da Extração Por Infusãounclassified

AVALIAÇÃO DE COMPOSTOS BIOATIVOS E ATIVIDADE ANTIOXIDANTE DE EXTRATOS DE FOLHAS DE AMOREIRA PRETA (Morus nigra L.) UTILIZANDO PLANEJAMENTO EXPERIMENTAL

Schafranski¹,

Postigo²,

Vitali³

et al. 2019

Quím. Nova

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EVALUATION OF BIOATIVE COMPOUNDS AND ANTIOXIDANT ACTIVITY OF EXTRACTS OF BLACK MULBERRY LEAVES (Morus nigra L.) USING EXPERIMENTAL DESIGN. Extracts of black mulberry leaves present phytochemicals such as phenolic compounds and minerals. These substances have been studied because they show several health benefits. In this work we report the influence of drying temperature, infusion temperature and extraction time by means of factorial design monitoring the total phenolic content (CFT) of aqueous extracts of leaves of Morus nigra L. The concentrations of CFT, flavonoids, flavonols and antioxidant activity of the extracts were determined by spectrophotometry. The identification and quantification of phenolic compounds were performed by LC-ESI-MS / MS. The determination of the mineral concentration in the black mulberry leaves was performed by ICP-MS. The Pareto and surface response graphs suggested that the most efficient extractions occurred for leaves drying at lower temperatures and using higher infusion temperatures, extraction time did not show significant influence. The extracts presented concentration of CFT from 16.96 ± 0.15 to 5.73 ± 0.33 mg GAE g-1. The analyzes by LC-ESI-MS / MS allowed to identify phenolic substances not yet reported in the literature to date. In addition 10 mineral elements were determined in the black mulberry leaves at mg kg-1 concentrations range.

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“…e antioxidant capacities of MD extracts were evaluated by DPPH radical scavenging assay described by Maira with some modifications [15]. Firstly, 3.5 mL of 0.07 mM DPPH solution was mixed with 0.4 mL of extracts and then incubated in the dark at room temperature for 30 min.…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

“…An ultrasonic extractor (DL-720J, Shanghai Zhixin Instrument Co., Ltd.) was used to extract antioxidants from MD. Firstly, about 0.1 g MD powder was weighted accurately and mixed with various volumes (10,20,30,40, and 50 mL) of different concentrations of methanol aqueous solution (0, 25, 50, 75, and 100%, V methanol /V water ), and then the mixtures were treated with different times (15,30,45,60, and 75 min) at certain temperatures (25, 35, 45, and 55°C). After extraction, the samples were cooled to room temperature and centrifuged at 3500 rpm for 15 min.…”

Section: Ultrasound-assisted Extraction Of Antioxidants In MDmentioning

confidence: 99%

Extraction, Enrichment, and Quantification of Main Antioxidant Aglycones of Flavonoids and Tannins from Melastoma Dodecandrum Lour.: Guided by UPLC-ESI-MS/MS

Tong

Jiang

Chen

et al. 2019

Journal of Chemistry

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The objective of this work was to determine the main antioxidant aglycones of flavonoids and tannins in antioxidant extracts from Melastoma dodecandrum Lour. (MD), based on its extraction and purification process optimization and component identification by UPLC-ESI-MS/MS. Firstly, the ultrasound-assisted extraction (UAE) process for antioxidants was established by using single factor tests and response surface optimization. Evaluating by DPPH radical scavenging assay, the antioxidant capacity of MD could reach 2742.27 ± 93.86 (μmol Trolox/g) under the optimized conditions including methanol concentration (61%, v/v), extraction time (45 min), liquid-solid ratio (0.46 ml/mg), and extraction temperature (25°C). Then, the antioxidants in the solution were enriched by using macroporous resins. Because of the highest adsorption capacity and desorption ratio, HPD 500 was selected out of 14 macroporous resins for further study based on the static adsorption and desorption tests. The adsorption mechanism of the HPD 500 resin presented that pseudo-first-order kinetics model and Freundlich isotherm model could adequately explain the adsorption process. After the antioxidants were dynamically saturated by HPD 500, the column was eluted with different concentrations of ethanol (0, 25, 50, 75, and 100%, v/v). Among the above five ethanol fractions, 50% ethanol fraction showed the strongest antioxidant activity and more than 95% antioxidants adsorbed in HPD500 could be eluted by 75% ethanol. Guided by analysis results of UPLC-ESI-MS/MS, main antioxidant aglycones of flavonoids and tannins in each ethanol elution fraction were quantitatively detected. Finally, according to the correlation analysis between the antioxidant capacity of each ethanol elution fraction and its content of 10 main flavonoids and phenolic acids, the antioxidant activities of MD could mainly contribute to tannins containing phenolic units such as ellagic acid and/or gallic acid. The results of this work would provide useful information for the production of antioxidants from MD. Thus, the analysis methods could also be a quality control tool for material or products related with MD.

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Influence of time, temperature and solvent on the extraction of bioactive compounds of Baccharis dracunculifolia: In vitro antioxidant activity, antimicrobial potential, and phenolic compound quantification

Cited by 63 publications

References 66 publications

Valorisation of Exhausted Olive Pomace by an Eco-Friendly Solvent Extraction Process of Natural Antioxidants

Valorisation of Exhausted Olive Pomace by an Eco-Friendly Solvent Extraction Process of Natural Antioxidants

AVALIAÇÃO DE COMPOSTOS BIOATIVOS E ATIVIDADE ANTIOXIDANTE DE EXTRATOS DE FOLHAS DE AMOREIRA PRETA (Morus nigra L.) UTILIZANDO PLANEJAMENTO EXPERIMENTAL

Extraction, Enrichment, and Quantification of Main Antioxidant Aglycones of Flavonoids and Tannins from Melastoma Dodecandrum Lour.: Guided by UPLC-ESI-MS/MS

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