2009
DOI: 10.1590/s0100-879x2009005000014
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Influence of the polymorphisms of the α-major regulatory element HS-40 on in vitro gene expression

Abstract: The α-MRE is the major regulatory element responsible for the expression of human α-like globin genes. It is genetically polymorphic, and six different haplotypes, named A to F, have been identified in some population groups from Europe, Africa and Asia and in native Indians from two Brazilian Indian tribes. Most of the mutations that constitute the α-MRE haplotypes are located in flanking sequences of binding sites for nuclear factors. To our knowledge, there are no experimental studies evaluating whether suc… Show more

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Cited by 3 publications
(2 citation statements)
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“…Ribeiro et al (2009) examined the dose-response effects of exogenous anandamide at doses of 0.01, 0.1, and 1.0 mg/kg in mice sequentially submitted to the open field and EPM. Systemically administered at 0.1 mg/kg (but not at 0.01 or 1 mg/kg), anandamide increases the time spent and the distance covered in the central zone of the open field, as well as exploration of the open arms of the EPM.…”
Section: Effects Of Cannabinoids On Stress and Anxietymentioning
confidence: 99%
“…Ribeiro et al (2009) examined the dose-response effects of exogenous anandamide at doses of 0.01, 0.1, and 1.0 mg/kg in mice sequentially submitted to the open field and EPM. Systemically administered at 0.1 mg/kg (but not at 0.01 or 1 mg/kg), anandamide increases the time spent and the distance covered in the central zone of the open field, as well as exploration of the open arms of the EPM.…”
Section: Effects Of Cannabinoids On Stress and Anxietymentioning
confidence: 99%
“…Whether or not HS‐40 haplotypes affect HBA1/HBA2 gene expression, as reflected by the α/β globin biosynthesis ratios, or alter the properties of erythrocytes, estimated by MCV and MCH, have not been definitively determined. Expression of a luciferase reporter in K562 cells was greatest when the enhancer was the 350 bp core element of the A haplotype of HS‐40(Ribeiro et al , ). The relationship of haplotypes of HS‐40—haplotypes of other HBA1/HBA2 gene regulatory elements have yet to be described— to rs7203560 is unknown.…”
Section: Discussionmentioning
confidence: 99%