Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats

Wang, Xin Yu; Ishida, Tatsuhiro; Ichihara, Masako; Kojima, Hiroshi

doi:10.1016/j.jconrel.2005.01.008

Cited by 68 publications

(51 citation statements)

References 37 publications

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“…36 Liposomes have been used in the delivery of anticancer drugs and are able to alter the biodistribution and clearance of drug molecules. 37,38 Intravenously (iv) administered liposomes are taken up by the reticuloendothelial system (RES) after entering the body. Liposomal drugs mainly accumulate in the liver, spleen, lung, bone marrow or other tissues and organs so as to improve the therapeutic index of drugs and reduce their side effects.…”

Section: Introductionmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

304

208

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Curcumin (CUR) is a yellow polyphenolic compound derived from the plant turmeric. It is widely used to treat many types of diseases, including cancers such as those of lung, cervices, prostate, breast, bone and liver. However, its effectiveness has been limited due to poor aqueous solubility, low bioavailability and rapid metabolism and systemic elimination. To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. Among these, liposomes have been the most extensively studied. Liposomal CUR formulation has greater growth inhibitory and pro-apoptotic effects on cancer cells. This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Liposomal curcumin and its application in cancer

Feng¹,

Wei²,

Lee³

et al. 2017

IJN

304

208

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“…It is worthy to note that the blood half-lives of Pal-PLS was shorter than that of liposomes which was reported by Wang et al 14) Because Pal-PLS was released from liposomes and was converted to PLS in blood, Pal-PLS must disappear from blood faster than liposomes themselves. Another possibility is impairment of liposomal stability in blood by insertion of Pal-PLS into the liposomal membrane.…”

Section: Discussionmentioning

confidence: 80%

PEGylated Liposomes Loading Palmitoyl Prednisolone for Prolonged Blood Concentration of Prednisolone

Teshima

Kawakami

Fumoto

et al. 2006

Biological & Pharmaceutical Bulletin

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“…29,30 Therefore, nanocarriers need to be fully characterized. Apart from PM, which measured 14.3±1.4 nm, the mean particle size of the PEGylated nanocarriers was in the range of 120-140 nm.…”

Section: The Characteristics Of Various Pegylated Nanocarriersmentioning

confidence: 99%

Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs

Cheng¹,

Su²,

Pei³

et al. 2015

IJN

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The cross-administration of nanocarriers modified by poly(ethylene glycol) (PEG), named PEGylated nanocarriers, a type of combination therapy, is becoming an increasingly important method of long-term drug delivery, to decrease side effects, avoid multidrug resistance, and increase therapeutic efficacy. However, repeated injections of PEGylated nanocarriers induces the accelerated blood clearance (ABC) phenomenon, prevents long circulation, and can cause adverse effects owing to alterations in the biodistribution of the drug. Although the nature of the ABC phenomenon that is induced by repeated injections of PEGylated nanocarriers has already been studied in detail, there are few reports on the immune response elicited by the cross-administration of PEGylated nanocarriers. In this study, we investigated the ABC phenomenon induced by the intravenous cross-administration of various PEGylated nanocarriers, including PEGylated liposomes (PL), PEG micelles (PM), PEGylated solid lipid nanoparticles (PSLN), and PEGylated emulsions (PE), in beagle dogs. The results indicated that the magnitude of the immune response elicited by the cross-administration was in the following order (from the strongest to the weakest): PL, PE, PSLN, PM. It is specifically PEG in the brush structure that elicits a significant immune response, in both the induction phase and the effectuation phase. Furthermore, the present study suggests that there is a considerable difference between the effect of repeated injections and cross-administration, depending on the colloidal structure. This work is a preliminary investigation into the cross-administration of PEGylated nanocarriers, and our observations can have serious implications for the design of combination therapies that use PEGylated vectors.

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Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats

Cited by 68 publications

References 37 publications

Liposomal curcumin and its application in cancer

Liposomal curcumin and its application in cancer

PEGylated Liposomes Loading Palmitoyl Prednisolone for Prolonged Blood Concentration of Prednisolone

Accelerated blood clearance phenomenon upon cross-administration of PEGylated nanocarriers in beagle dogs

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