Influence of the nature of quantum dot surface cations on interactions with DNA

Mahtab, Rahina; Sealey, Sheldon M.; Hunyadi, Simona E.; Kinard, Brian; Ray, Tyler R.; Murphy, Catherine J.

doi:10.1016/j.jinorgbio.2006.11.019

Cited by 26 publications

(26 citation statements)

References 31 publications

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“…The suggestion that RNA-like polymers could bind, via negatively charged phosphate groups, to ZnS surfaces is supported by the ready adsorption of nucleic acids on the ZnS/CdS nanoparticles [243,247,328,[334][335][336][337][338][339][340] The assembly of RNA-like polymers at the ZnS surface should be greatly facilitated by the complementary match between the patterns of electrically charged groups at the surfaces of polynucleotides and ZnS, respectively. Such a matching was shown for the CdS nanoparticles, which formed spontaneously from added cadmium salts in the presence of polynucleotides as templates [341,342].…”

Section: First Settlers In the Zns Worldmentioning

confidence: 99%

“…Still, while sifting through the literature on the interaction of nucleobases, polynucleotides, and proteins with ZnS/CdS nanoparticles (see e.g. [242][243][244]246,247,328,[334][335][336][337][338][339][340][341][342][361][362][363][364]385]), it is difficult to avoid the impression that the "intrinsic affinity of (poly)nucleotides for semiconductor surfaces" (quoted from ref. [334]) is particularly specific.…”

Section: Colonization Wavesmentioning

confidence: 99%

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Inorganic Polyphosphate Modulates TRPM8 Channels

Trimm¹

2011

Inorganic Chemistry

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Section: First Settlers In the Zns Worldmentioning

confidence: 99%

Section: Colonization Wavesmentioning

confidence: 99%

Inorganic Polyphosphate Modulates TRPM8 Channels

Trimm¹

2011

Inorganic Chemistry

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“…The research of QDs mainly concentrated on their use as fluorescent probes on labeling biomacromolecules and animal cells [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and application of intercellular Ca2+-sensitive fluorescent probe based on quantum dots

Xia¹,

Yu²,

Liao³

et al. 2013

Journal of Inorganic Biochemistry

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“…Several macroscopic methods, such as spectroscopic [34,35] and electrochemical [36] techniques, were employed to investigate the thermodynamic equilibrium constants and binding specificities of NPs to DNA. Although powerful, these methods cannot determine the binding affinity of NPs for specific sites on DNA and are limited by assuming that the change in the instrumental signal like absorbance is directly proportional to the extent of binding [37].…”

Section: 3mentioning

confidence: 99%

Atomic Force Microscopy Study of the Interaction of DNA and Nanoparticles

Ginkel

et al. 2014

Advances in Experimental Medicine and Biology

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The interaction between nanoparticles (NPs) and DNA plays an important role in the genotoxicity of NPs, and it is imperative to characterize the nano/DNA interactions and explore the underlying chemical mechanisms. In this chapter, we demonstrated systematic experimental approaches based on atomic force microscope (AFM), coupled with modeling computation to probe the binding activity of NPs with DNA and the putative genotoxicity. Using quantum dots (QDs) as a model NP, we examined the binding kinetics, binding isotherm, binding specificity, and binding mechanisms of NPs to DNA with the application of AFM. We further assessed the binding affinity between NPs and DNA by calculating their interaction energy on the basis of Derjaguin-Landau-Verwey-Overbeek (DLVO) models. The modeling results of binding affinity were validated by the NPs/DNA binding images experimentally derived by AFM. The investigation of the relationship between the binding affinity of five NPs ((QDs (+), QDs (-), silver NPs, hematite NPs, and gold NPs) for DNA with their inhibition effects on DNA replication indicated that NPs with a high binding affinity for DNA molecules exhibited higher inhibition on DNA replication. The methodology employed in this study can be extended to study the interaction of other NPs with DNA, which is anticipated to benefit the future design of safe NPs, as well as the toxicological investigations of NPs.

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Influence of the nature of quantum dot surface cations on interactions with DNA

Cited by 26 publications

References 31 publications

Inorganic Polyphosphate Modulates TRPM8 Channels

Inorganic Polyphosphate Modulates TRPM8 Channels

Synthesis and application of intercellular Ca2+-sensitive fluorescent probe based on quantum dots

Atomic Force Microscopy Study of the Interaction of DNA and Nanoparticles

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