Influence of the menstrual cycle phase on the therapeutic response in schizophrenia

Gattaz, Wagner F.; Vogel, Peter; Riecher-Rössler, Anita; Soddu, G.

doi:10.1016/0006-3223(94)91195-9

Cited by 79 publications

(34 citation statements)

References 10 publications

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“…As detailed in the Introduction, it has been suggested that exogenous estrogen may have antipsychotic properties or increase response to APDs in women with schizophrenia. Although the latter has been supported in several studies (Agius et al, 2009;Akhondzadeh et al, 2003;Cyr et al, 2002;Korhonen et al, 1995;Kulkarni, 2009;Kulkarni et al, 1996Kulkarni et al, , 2001Kulkarni et al, , 2008aLindamer et al, 2001;Mortimer, 2007;Rao and Kolsch, 2003), other studies reported that estrogen treatment failed to improve or even worsened symptoms (Bergemann et al, 2005;Chua et al, 2005;Gattaz et al, 1994;Lindamer et al, 2001; for review see Mortimer, 2007). We previously provided support for antipsychotic capacity of 17b-estradiol by showing a synergistic effect of ineffective doses of 17b-estradiol and APDs in reversing OVX-induced disrupted LI , and have replicated such a synergistic effect here for amphetamine-induced disrupted LI.…”

Section: Discussionmentioning

confidence: 90%

Contrasting Effects of Increased and Decreased Dopamine Transmission on Latent Inhibition in Ovariectomized Rats and Their Modulation by 17β-Estradiol: An Animal Model of Menopausal Psychosis?

Arad

Weiner

2010

Neuropsychopharmacol

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Women with schizophrenia have later onset and better response to antipsychotic drugs (APDs) than men during reproductive years, but the menopausal period is associated with increased symptom severity and reduced treatment response. Estrogen replacement therapy has been suggested as beneficial but clinical data are inconsistent. Latent inhibition (LI), the capacity to ignore irrelevant stimuli, is a measure of selective attention that is disrupted in acute schizophrenia patients and in rats and humans treated with the psychosisinducing drug amphetamine and can be reversed by typical and atypical APDs. Here we used amphetamine (1 mg/kg)-induced disrupted LI in ovariectomized rats to model low levels of estrogen along with hyperfunction of the dopaminergic system that may be occurring in menopausal psychosis, and tested the efficacy of APDs and estrogen in reversing disrupted LI. 17b-Estradiol (50, 150 mg/kg), clozapine (atypical APD; 5, 10 mg/kg), and haloperidol (typical APD; 0.1, 0.3 mg/kg) effectively reversed amphetamine-induced LI disruption in sham rats, but were much less effective in ovariectomized rats; 17b-estradiol and clozapine were effective only at high doses (150 mg/kg and 10 mg/kg, respectively), whereas haloperidol failed at both doses. Haloperidol and clozapine regained efficacy if coadministered with 17b-estradiol (50 mg/kg, an ineffective dose). Reduced sensitivity to dopamine (DA) blockade coupled with spared/potentiated sensitivity to DA stimulation after ovariectomy may provide a novel model recapitulating the combination of increased vulnerability to psychosis with reduced response to APD treatment in female patients during menopause. In addition, our data show that 17b-estradiol exerts antipsychotic activity.

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Section: Discussionmentioning

confidence: 90%

Contrasting Effects of Increased and Decreased Dopamine Transmission on Latent Inhibition in Ovariectomized Rats and Their Modulation by 17β-Estradiol: An Animal Model of Menopausal Psychosis?

Arad

Weiner

2010

Neuropsychopharmacol

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“…Postmenopausally, there is elevation in the severity of symptoms and reduced response to treatment, as well as an additional onset peak in women after the age of 40-45 (Horacek et al 2006;Kulkarni et al 1996;Kulkarni et al 2008;Lane et al 1999;Salokangas 1995;Saugstad 1989;Seeman and Lang 1990). Likewise, during reproductive years, intensity of psychosis in schizophrenic women fluctuates along the menstrual cycle so that women are most vulnerable to exacerbation and relapse during low estrogen phases of the cycle (Gattaz et al 1994;Hallonquist et al 1993;Opjordsmoen 1991;Riecher-Rossler et al 1994;Seeman 1996). Estrogen level fluctuations correlate also with treatment efficacy, so that during high levels of estrogen, schizophrenic women require lower doses of antipsychotic drugs (APDs; Gattaz et al 1994;Grigoriadis and Seeman 2002).…”

Section: Introductionmentioning

confidence: 92%

“…Likewise, during reproductive years, intensity of psychosis in schizophrenic women fluctuates along the menstrual cycle so that women are most vulnerable to exacerbation and relapse during low estrogen phases of the cycle (Gattaz et al 1994;Hallonquist et al 1993;Opjordsmoen 1991;Riecher-Rossler et al 1994;Seeman 1996). Estrogen level fluctuations correlate also with treatment efficacy, so that during high levels of estrogen, schizophrenic women require lower doses of antipsychotic drugs (APDs; Gattaz et al 1994;Grigoriadis and Seeman 2002).…”

Section: Introductionmentioning

confidence: 97%

Disruption of latent inhibition induced by ovariectomy can be reversed by estradiol and clozapine as well as by co-administration of haloperidol with estradiol but not by haloperidol alone

Arad

Weiner

2009

Psychopharmacology

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“…Sie schlossen daraus, dass Östrogene wie ein "endogenes Neuroleptikum" wirken. Zusammen mit Gattaz et al [31] fanden wir bei schizophreniekranken Frauen, die während des Perimenstruums stationär aufgenommen worden waren, im weiteren Verlauf ein vergleichsweise besseres therapeutisches Ansprechen, möglicherweise bedingt durch den postmenstruell dann unmittelbar ansteigenden Estradiolspiegel.…”

Section: Beobachtungen Aus Epidemiologischen Und Klinischen Studienunclassified

Östrogene und gonadale Achse Implikationen für die Therapie von Frauen mit Schizophrenien

Riecher-Rössler¹

2003

Nervenarzt

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Estrogens significantly influence the mental states of women and probably modulate many mental diseases. Concerning schizophrenic psychoses, there is increasing evidence for a protective effect of estrogens on the one hand and gonadal dysfunction and hypoestrogenism in many women with schizophrenia on the other. This results in the urgent need to pay more attention to the gonadal axis and estrogen status in women with schizophrenia, both in research and in practice.

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Influence of the menstrual cycle phase on the therapeutic response in schizophrenia

Cited by 79 publications

References 10 publications

Contrasting Effects of Increased and Decreased Dopamine Transmission on Latent Inhibition in Ovariectomized Rats and Their Modulation by 17β-Estradiol: An Animal Model of Menopausal Psychosis?

Contrasting Effects of Increased and Decreased Dopamine Transmission on Latent Inhibition in Ovariectomized Rats and Their Modulation by 17β-Estradiol: An Animal Model of Menopausal Psychosis?

Disruption of latent inhibition induced by ovariectomy can be reversed by estradiol and clozapine as well as by co-administration of haloperidol with estradiol but not by haloperidol alone

Östrogene und gonadale Achse Implikationen für die Therapie von Frauen mit Schizophrenien

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