Influence of terahertz laser radiation on the spectral characteristics and functional properties of albumin

Biomedical Applications of Terahertz Spectroscopy and Imaging

“…However, THz irradiation may induce some changes at the biomolecule level, such as DNA [ 2 2 _ T D $ D I F F ] damages [89,90], gene expression alterations [91], and protein changes [92]. Given that no obvious temperature rise was observed in these studies, most of the results are associated with proposed nonthermal effects of low-level THz irradiation, wherein THz radiation induced lowfrequency collective biomolecular vibrations [90].…”

Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation

“…In 2009, Cherkasova et al examined the direct effects of THz radiation on spectral and functional properties of albumin [22]. In this work, the authors exposed lypholized bovine serum albumin (BSA) to THz radiation using a FIR THz source (3.6 THz, 10 mWcm −2 , 60 min).…”

“…In recent years, many timely investigations have been performed to investigate the possible biological effects associated with THz radiation [12][13][14][15][16][17][18][19][20][21][22]. Unfortunately, however, a comprehensive review has not yet appeared in the literature which both discusses the fundamental interaction mechanisms, and also critically reviews the bioeffects studies that have been conducted to date.…”

Regulatory effects of terahertz waves

“…During the THz irradiation of albumin protein samples there had been revealed conformational transitions of these macromolecules. These transitions had been registered by different spectroscopic methods, which let fix changes in correlation fractions of condensed and folded structures, and changes in optical albumin density in absorption area of peptid and disulfide bonds [14][15][16][17]. This indicates that THz irradiation induces conformational change in albumin molecules caused by the change in its bonding property.…”

“…This fact is confirmed by the study of persistent THz irradiation influence of 3.68 THz frequency on bonding albumin with progesterone, which is performed by hydrophobic interaction of bonding centers with rests of triptophane, tyrosine, arginine and lysine. It had been showed that albumin bonding property, irradiated by THz waves, increases [14,18].…”