Influence of streptozotocin (STZ)-induced diabetes, dextrose diuresis and aceton on cisplatin nephrotoxicity in Fischer 344 (F344) rats

The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs

“…Examination of the effect of glycosuric diuresis and ketone bodies on cisplatin nephrotoxicity following acetone pretreatment of normoglycemic rats, indicated that the experimental DM state did not attenuate cisplatin nephrotoxicity through glycosuric diuresis (Scott, Madan, & Valentovic, ).…”

“…Examination of the effect of glycosuric diuresis and ketone bodies on cisplatin nephrotoxicity following acetone pretreatment of normoglycemic rats, indicated that the experimental DM state did not attenuate cisplatin nephrotoxicity through glycosuric diuresis (Scott, Madan, & Valentovic, 1990). Valentovic et al (1991) measured urinary platinum (Pt) excretion following administration of cisplatin to STZ-DM and non-DM rats; in DM rats, the renal accumulation of Pt decreased and its renal excretion increased, compared to non-DM rats.…”

The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs

“…Examination of the effect of glycosuric diuresis and ketone bodies on cisplatin nephrotoxicity following acetone pretreatment of normoglycemic rats, indicated that the experimental DM state did not attenuate cisplatin nephrotoxicity through glycosuric diuresis (Scott, Madan, & Valentovic, ).…”

“…Examination of the effect of glycosuric diuresis and ketone bodies on cisplatin nephrotoxicity following acetone pretreatment of normoglycemic rats, indicated that the experimental DM state did not attenuate cisplatin nephrotoxicity through glycosuric diuresis (Scott, Madan, & Valentovic, 1990). Valentovic et al (1991) measured urinary platinum (Pt) excretion following administration of cisplatin to STZ-DM and non-DM rats; in DM rats, the renal accumulation of Pt decreased and its renal excretion increased, compared to non-DM rats.…”

Renal Metallothionein and Platinum Levels in Diabetic and Nondiabetic Rats Injected with Cisplatin

“…One obvious effect of diabetes is osmotic diuresis which might accelerate Pt excretion. However, Scott et al (2) have demonstrated that glucose-induced diuresis offers no protection from cisplatin nephrotoxicity. A more likely possibility is decreased uptake by the tubular cells, a mechanism which, though little studied in the kidney, seems clearly to play a role in the acquired resistance of some tumor cells to cisplatin toxicity (25).…”

The Prevention of Cisplatin-Induced Nephrotoxicity: A General Consensus Statement of a Group of Oncologist-Hematologists, Adult and Pediatric Nephrologists, Radiation Oncologists, Clinical Pathologists, Clinical Pharmacologists, and Renal Physiologists on Cisplatin Therapy in Cancer Patients

“…We suggested several new points that need to be considered during CP administration. Female sex hormone estrogen,[ 9 25 26 27 28 ] hydration with dextrose,[ 10 31 ] and concurrent use of renin–angiotensin system inhibitor drugs[ 5 23 24 ] are the subjects that included in this general consensus. In order to obtain a more complete general consensus or guideline for CP therapy, more clinical trial researches are needed.…”

The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs

“…Examination of the effect of glycosuric diuresis and ketone bodies on cisplatin nephrotoxicity following acetone pretreatment of normoglycemic rats, indicated that the experimental DM state did not attenuate cisplatin nephrotoxicity through glycosuric diuresis (Scott, Madan, & Valentovic, ).…”

“…Examination of the effect of glycosuric diuresis and ketone bodies on cisplatin nephrotoxicity following acetone pretreatment of normoglycemic rats, indicated that the experimental DM state did not attenuate cisplatin nephrotoxicity through glycosuric diuresis (Scott, Madan, & Valentovic, 1990). Valentovic et al (1991) measured urinary platinum (Pt) excretion following administration of cisplatin to STZ-DM and non-DM rats; in DM rats, the renal accumulation of Pt decreased and its renal excretion increased, compared to non-DM rats.…”

Renal Metallothionein and Platinum Levels in Diabetic and Nondiabetic Rats Injected with Cisplatin

“…One obvious effect of diabetes is osmotic diuresis which might accelerate Pt excretion. However, Scott et al (2) have demonstrated that glucose-induced diuresis offers no protection from cisplatin nephrotoxicity. A more likely possibility is decreased uptake by the tubular cells, a mechanism which, though little studied in the kidney, seems clearly to play a role in the acquired resistance of some tumor cells to cisplatin toxicity (25).…”

The Prevention of Cisplatin-Induced Nephrotoxicity: A General Consensus Statement of a Group of Oncologist-Hematologists, Adult and Pediatric Nephrologists, Radiation Oncologists, Clinical Pathologists, Clinical Pharmacologists, and Renal Physiologists on Cisplatin Therapy in Cancer Patients

“…We suggested several new points that need to be considered during CP administration. Female sex hormone estrogen,[ 9 25 26 27 28 ] hydration with dextrose,[ 10 31 ] and concurrent use of renin–angiotensin system inhibitor drugs[ 5 23 24 ] are the subjects that included in this general consensus. In order to obtain a more complete general consensus or guideline for CP therapy, more clinical trial researches are needed.…”

The effect of diabetes mellitus on pharmacokinetics, pharmacodynamics and adverse drug reactions of anticancer drugs

“…Examination of the effect of glycosuric diuresis and ketone bodies on cisplatin nephrotoxicity following acetone pretreatment of normoglycemic rats, indicated that the experimental DM state did not attenuate cisplatin nephrotoxicity through glycosuric diuresis (Scott, Madan, & Valentovic, ).…”

“…Examination of the effect of glycosuric diuresis and ketone bodies on cisplatin nephrotoxicity following acetone pretreatment of normoglycemic rats, indicated that the experimental DM state did not attenuate cisplatin nephrotoxicity through glycosuric diuresis (Scott, Madan, & Valentovic, 1990). Valentovic et al (1991) measured urinary platinum (Pt) excretion following administration of cisplatin to STZ-DM and non-DM rats; in DM rats, the renal accumulation of Pt decreased and its renal excretion increased, compared to non-DM rats.…”

Renal Metallothionein and Platinum Levels in Diabetic and Nondiabetic Rats Injected with Cisplatin

“…One obvious effect of diabetes is osmotic diuresis which might accelerate Pt excretion. However, Scott et al (2) have demonstrated that glucose-induced diuresis offers no protection from cisplatin nephrotoxicity. A more likely possibility is decreased uptake by the tubular cells, a mechanism which, though little studied in the kidney, seems clearly to play a role in the acquired resistance of some tumor cells to cisplatin toxicity (25).…”

The Prevention of Cisplatin-Induced Nephrotoxicity: A General Consensus Statement of a Group of Oncologist-Hematologists, Adult and Pediatric Nephrologists, Radiation Oncologists, Clinical Pathologists, Clinical Pharmacologists, and Renal Physiologists on Cisplatin Therapy in Cancer Patients

“…We suggested several new points that need to be considered during CP administration. Female sex hormone estrogen,[ 9 25 26 27 28 ] hydration with dextrose,[ 10 31 ] and concurrent use of renin–angiotensin system inhibitor drugs[ 5 23 24 ] are the subjects that included in this general consensus. In order to obtain a more complete general consensus or guideline for CP therapy, more clinical trial researches are needed.…”