Arch Dermatol
 1959
DOI: 10.1001/archderm.1959.01560130088010
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Influence of Specific Antibody on Herpes Simplex Infections in Tissue Culture

Clayton E. Wheeler1
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Cited by 24 publications

(8 citation statements)
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“…13 The high level of specific antibody in this patient's se¬ rum was clearly ineffective in preventing re¬ currences of eczema herpeticum, and it was incapable of destroying the herpes simplex virus that probably remains latent in the tis¬ sue between recurrences. The clinical descriptions of the recurrent, widespread grouped vesiculopustular eruptions have been quite similar.…”
Section: Commentmentioning
confidence: 80%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…13 The high level of specific antibody in this patient's se¬ rum was clearly ineffective in preventing re¬ currences of eczema herpeticum, and it was incapable of destroying the herpes simplex virus that probably remains latent in the tis¬ sue between recurrences. The clinical descriptions of the recurrent, widespread grouped vesiculopustular eruptions have been quite similar.…”
Section: Commentmentioning
confidence: 80%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Change in virulence or in other characteristics of the virus has not been prominently mentioned in studies of virus carrier systems (Ginsberg, 1958). Wheeler and Canby (1959), for instance, studied carrier cultures of herpes virus using antibody containing culture procedures not very different from those used by us and by Hoggan and Roizman, and yet they apparently did not observe changes in the characteristics of the virus. In some carrier systems studied by other investigators, the virus has ceased to produce CPE, but this has usually been attributed to an increase in cell resistance by cell selection or some other mechanism, such as interference.…”
Section: Discussionmentioning
confidence: 91%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The sequence of events outlined above for persistent MAL cell infections in the presence of AB suggested that the changes noted in the severity of the infections after the appearance of the GC variant were partially dependent on fluctuations in the proportion of virus-resistant cells in the population. This requirement for resistant cells makes it improbable that similar changes would occur in persistent HSV infections where all of the cells were susceptible to virus (1,3,10,13,16,17). If viral changes comparable to the NP and GC variants occurred in such infections, one would expect to see an increase in the severity of the infections, such as described in the MAL cell system during phases 1 and 3, since such a change could be accounted for by an increase in the amount of infectious virus available for disseminating the infection.…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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