2020
DOI: 10.1159/000510853
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Abstract: <b><i>Background:</i></b> Preliminary evidence is promising regarding the anxiolytic effects of statins in animal models of anxiety. Hence, this study aimed to evaluate the efficacy of simvastatin augmentation versus placebo in the treatment of patients with generalized anxiety disorder (GAD) with residual symptoms despite treatment with selective serotonin reuptake inhibitors (SSRIs). <b><i>Methods:</i></b> A double-blind, 8-week controlled trial was conducted f… Show more

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Cited by 3 publications
(2 citation statements)
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References 64 publications
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“…Recent studies of Molero et al 150 and Mirzaei et al 144 have not found an association between statin treatment in patients and suicidality or anxiety disorders (Table 1 ).…”
Section: Cardiovascular Drugs and Anxietymentioning
confidence: 89%
“…Recent studies of Molero et al 150 and Mirzaei et al 144 have not found an association between statin treatment in patients and suicidality or anxiety disorders (Table 1 ).…”
Section: Cardiovascular Drugs and Anxietymentioning
confidence: 89%
“…A small study failed to demonstrate a benefit for simvastatin as augmentation therapy to treat GAD [28].…”
Section: Pharmacotherapymentioning
confidence: 99%