Influence of silymarin and its flavonolignans on H2O2-induced oxidative stress in human keratinocytes and mouse fibroblasts

Svobodová, Alena Rajnochová; Walterová, Daniela; Psotová, Jitka

doi:10.1016/j.burns.2006.04.004

Cited by 70 publications

(53 citation statements)

References 15 publications

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“…Recently we demonstrated that pre-treatment with SM and its main flavonolignan component silybin protected oxidative damage to HaCaT induced by hydrogen peroxide that is extensively generated during UVA exposure [34]. In this report we deal with influence of SM treatment to UVA-irradiated keratinocytes.…”

Section: Discussionmentioning

confidence: 96%

Attenuation of UVA-induced damage to human keratinocytes by silymarin

Svobodová

Zdařilová

Malisková

et al. 2007

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 96%

Attenuation of UVA-induced damage to human keratinocytes by silymarin

Svobodová

Zdařilová

Malisková

et al. 2007

Journal of Dermatological Science

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“…ROS can rapidly be removed by non-enzymatic and enzymatic antioxidants that prevent their harmful effects and maintain a prooxidant/oxidant balance [43]. Glutathione (GSH) is a multifunctional intracellular non-enzymatic antioxidant.…”

Section: Discussionmentioning

confidence: 99%

Effect of Curcumin Against Oxidation of Biomolecules by Hydroxyl Radicals

Borra

Mahendra

Gurumurthy

et al. 2014

JCDR

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Background: Among various reactive oxygen species, hydroxyl radicals have the strongest chemical activity, which can damage a wide range of essential biomolecules such as lipids, proteins, and DNA.Objective: The objective of this study was to investigate the beneficial effects of curcumin on prevention of oxidative damage of biomolecules by hydroxyl radicals generated in in vitro by a Fenton like reaction. Materials and Methods:We have incubated the serum, plasma and whole blood with H 2 O 2 /Cu 2 + / Ascorbic acid system for 4 hours at 37 0 C and observed the oxidation of biomolecules like albumin, lipids, proteins and DNA.Results: Curcumin at the concentrations of 50,100 and 200 µmoles, prevented the formation of ischemia modified albumin, MDA, protein carbonyls, oxidized DNA and increased the total antioxidant levels and GSH significantly. Conclusion:These observations suggest the hydroxyl radical scavenging potentials of curcumin and protective actions to prevent the oxidation of biomolecules by hydroxyl radicals.

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“…43 It was additionally reported that the administration of antioxidants enhanced the repair and healing process in cutaneous tissue; silymarin, the well-known antioxidant, was shown to be a useful agent for improving skin tissue regeneration and cutaneous healing. 44 Aljawad and Al-Ani 45 reported that some medicinal plants were able to accelerate the burn lesion healing rate -an effect related to these plants' containing antioxidant agents. All this evidence strongly supports results obtained in our study.…”

Section: Discussionmentioning

confidence: 99%