Influence of schistosomiasis on host vaccine responses

Nono, Justin Komguep; Kamdem, Séverin Donald; Musaigwa, Fungai; Nnaji, Chukwudi A; Brombacher, Frank

doi:10.1016/j.pt.2021.07.009

Cited by 13 publications

(19 citation statements)

References 65 publications

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“…Our observations now suggest a negative association between S. mansoni infection and the ability of the host to maintain serological memory against poliovirus in vaccinated hosts. This observation is consistent with our recent report of S. mansoni infection being associated with reduced responses to the measles virus vaccine in school-aged children from Bokito, Cameroon [8,13]. Additionally, weakened immune responses in S. mansoni infected children have been reported for the measles virus vaccine in Uganda [9], and the hepatitis B virus vaccine in Uganda [10] and Egypt [11].…”

Section: Discussionsupporting

confidence: 92%

“…In our study, CD138+ plasma B cells were substantially reduced in the bone marrow and moderately in the spleens of chronic S. mansoni infected mice. These observations suggest that the negative impact of S. mansoni could be rooted in the bone marrow in addition to satellite defects in the secondary lymphoid organ [13]. Noteworthy, the S. mansoni associated plasma cell reduction was well pronounced in bone marrow but poorly in the spleen, thus suggesting the concentrated impact of S. mansoni on bone marrow plasma cells through mechanisms that remain unclear.…”

Section: Plos Pathogensmentioning

confidence: 95%

“…Children in developing countries are particularly at risk of contracting this fresh water-borne parasite [14][15][16]. Considering the suggested impact of schistosomiasis on vaccine effectiveness [8][9][10][11][12][13], the overlapping endemicity of schistosomiasis and the critical need for vaccinating people could be an impending challenge, one that could be catastrophic without strategic interventions.…”

Section: Introductionmentioning

confidence: 99%

“…Concerningly, the reliance on EPI vaccines in developing countries often overlaps with the endemicity for helminths such as Schistosoma spp parasites [ 13 ]. Over 90% of all schistosomiasis disease cases, a highly debilitating disease with an estimated 258 million people infected globally [ 14 ], occur in sub-Saharan Africa alone [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses

et al. 2022

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Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms that remain unknown. Given the immunoregulatory dysregulation experienced in infected individuals, this study examined the impact of chronic schistosomiasis on the sustainability of vaccine-induced immunity in both children living in endemic areas and experimental infections in mice. Data show that chronic Schistosoma mansoni infection impaired the persistence of vaccine specific antibody responses in poliovirus-vaccinated humans and mice. Mechanistically, schistosomiasis primarily fostered plasmablast and plasma cell death in the bone marrow and removal of parasites following praziquantel treatment reversed the observed cell death and partially restored vaccine-induced memory responses associated with increased serum anti-polio antibody responses. Our findings strongly suggest a previously unrecognized mechanism to explain how chronic schistosomiasis interferes with an otherwise effective vaccine regimen and further advocates for therapeutic intervention strategies that reduce schistosomiasis burden in endemic areas prior to vaccination.

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Section: Discussionsupporting

confidence: 92%

Section: Plos Pathogensmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses

et al. 2022

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“…Health programs should seek to eliminate as many barriers as possible, which MDAs have achieved in creative ways, including bringing medications to people’s homes and schools, even in hard to reach areas. There may be further benefits to aligning COVID-19 vaccination campaigns with NTD MDA; schistosomiasis infection, for example, has been shown to reduce the efficacy of other vaccinations, suggesting that adults in endemic regions or higher-risk occupations (i.e., fishermen) should be offered praziquantel alongside the COVID-19 vaccine [ 32 ]. Overall, there remain substantial opportunities to think out of the box in terms of NTD integration and “hybrid” approaches to disease control, including future pandemic preparedness and response efforts [ 22 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

Safely resuming neglected tropical disease control activities during COVID-19: Perspectives from Nigeria and Guinea

McKay¹,

Shu'aibu²,

Cissé

et al. 2021

PLoS Negl Trop Dis

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Since its early spread in early 2020, the disease caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus Disease 2019 (COVID-19) has caused mass disruptions to health services. These have included interruptions to programs that aimed to prevent, control, and eliminate neglected tropical diseases (NTDs). In March 2020, the World Health Organization (WHO) released interim guidelines recommending the temporary cessation of mass drug administration (MDA), community-based surveys, and case detection, while encouraging continuation of morbidity management and vector control where possible. Over the course of the following months, national programs and implementing partners contributed to COVID-19 response efforts, while also beginning to plan for resumption of NTD control activities. To understand the challenges, opportunities, and recommendations for maximizing continuity of disease control during public health emergencies, we sought perspectives from Nigeria and Guinea on the process of restarting NTD control efforts during the COVID-19 pandemic. Through semistructured interviews with individuals involved with NTD control at the local and national levels, we identified key themes and common perspectives between the 2 countries, as well as observations that were specific to each. Overall, interviewees stressed the challenges posed by COVID-19 interruptions, particularly with respect to delays to activities and related knock-on impacts, such as drug expiry and prolonged elimination timelines, as well as concerns related to funding. However, respondents in both countries also highlighted the benefits of a formal risk assessment approach, particularly in terms of encouraging information sharing and increasing coordination and advocacy. Recommendations included ensuring greater availability of historical data to allow better monitoring of how future emergencies affect NTD control progress; continuing to use risk assessment approaches in the future; and identifying mechanisms for sharing lessons learned and innovations between countries as a means of advancing postpandemic health systems and disease control capacity strengthening.

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