1957
DOI: 10.3181/00379727-94-23012 View full text |Buy / Rent full text
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Abstract: Mines(l), reported that perfusion of an isolated frog heart with acid lengthened the A-V interval and led to heart block and that "perfusion with an alkaline solution quickly removed the block and then steadily reduces the A-1interval." Andrus and Carter (2) found that rhythm and conduction time in isolated dog's and terrapin's hearts could be correlated with pH of the perfusate. When an acid perfusate was used, rate slowed and conduction time lengthened. Opposite effects were observed when an alkaline perfusa… Show more

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“…Houle, Campbell and their associates have reported a similar reduction in the pressor responses of arterenol, epinephrine and metaraminol during respiratory aeiclosis. [22][23] The animals were hyperventilated in these experiments to prevent respiratory acidosis.…”
Section: Lactic Acid Infusionmentioning
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“…Houle, Campbell and their associates have reported a similar reduction in the pressor responses of arterenol, epinephrine and metaraminol during respiratory aeiclosis. [22][23] The animals were hyperventilated in these experiments to prevent respiratory acidosis.…”
Section: Lactic Acid Infusionmentioning
“…Interestingly, 24‐hour survival rates were not significantly different among study groups despite significant between‐group differences in blood pH (Table 1 ). Acidosis was suggested to exert adverse effects on heart contractility 22 , 23 and was associated with worse clinical outcomes after ROSC. 24 However, MAP was not significantly different among study groups (Figure 2D ).…”
Section: Discussionmentioning