Biochemical Pharmacology volume 81, issue 2, P295-303 2011 DOI: 10.1016/j.bcp.2010.10.010 View full text
Bavneet Benipal, Lawrence H. Lash

Abstract: A reduction in functional renal mass is common in numerous renal diseases and aging. The remaining functional renal tissue undergoes compensatory growth primarily due to hypertrophy. This is associated with a series of physiological, morphological and biochemical changes similar to those observed after uninephrectomy. Previous work showed that compensatory renal cellular hypertrophy resulted in an increase in susceptibility to several drugs and environmental chemicals and appeared to be associated with oxidati…

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