Influence of processing parameters on the macroscopic mechanical behavior of PVA hydrogels

Masri, Christopher; Chagnon, Grégory; Favier, Denis

doi:10.1016/j.msec.2017.02.045

Cited by 20 publications

(13 citation statements)

References 18 publications

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“…Mechanical properties of the PDCAH were summarized in Table S3. Young modulus (E) specifies the stiffness or rigidity of the film; tensile strength (σ) indicates the tensile strength of the film up to breaking; and the elongation at break (ε) describes the flexibility or extensibility of the films up to breaking [47].…”

Section: Resultsmentioning

confidence: 99%

Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

et al. 2019

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This research proposes the rational modeling, synthesis and evaluation of film dressing hydrogels based on polyvinyl alcohol crosslinked with 20 different kinds of dicarboxylic acids. These formulations would allow the sustained release of simultaneous bioactive compounds including allantoin, resveratrol, dexpanthenol and caffeic acid as a multi-target therapy in wound healing. Interaction energy calculations and molecular dynamics simulation studies allowed evaluating the intermolecular affinity of the above bioactive compounds by hydrogels crosslinked with the different dicarboxylic acids. According to the computational results, the hydrogels crosslinked with succinic, aspartic, maleic and malic acids were selected as the best candidates to be synthesized and evaluated experimentally. These four crosslinked hydrogels were prepared and characterized by FTIR, mechanical properties, SEM and equilibrium swelling ratio. The sustained release of the bioactive compounds from the film dressing was investigated in vitro and in vivo. The in vitro results indicate a good release profile for all four analyzed bioactive compounds. More importantly, in vivo experiments suggest that prepared formulations could considerably accelerate the healing rate of artificial wounds in rats. The histological studies show that these formulations help to successfully reconstruct and thicken epidermis during 14 days of wound healing. Moreover, the four film dressings developed and exhibited excellent biocompatibility. In conclusion, the novel film dressings based on hydrogels rationally designed with combinatorial and sustained release therapy could have significant promise as dressing materials for skin wound healing.

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Section: Resultsmentioning

confidence: 99%

Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

et al. 2019

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“…Along with the preparation of various PVACGs formed in aqueous media, cryogels produced by the freezing–thawing of dimethyl sulfoxide (DMSO) solutions [1,45,46,47,48,49] or DMSO- d 6 solutions [50,51] of the polymer are also known. Since DMSO is a thermodynamically better solvent than water for high-deacylated PVA samples [52], i.e., the affinity of DMSO to this polymer is higher compared to the affinity in the water–PVA pair, the PVA gelation in DMSO occurs poorly.…”

Section: Introductionmentioning

confidence: 99%

Cryostructuring of Polymeric Systems. 49. Unexpected “Kosmotropic-Like” Impact of Organic Chaotropes on Freeze–Thaw-Induced Gelation of PVA in DMSO

Lozinsky

Kolosova

Michurov

et al. 2018

Gels

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Urea (URE) and guanidine hydrochloride (GHC) possessing strong chaotropic properties in aqueous media were added to DMSO solutions of poly(vinyl alcohol) (PVA) to be gelled via freeze–thaw processing. Unexpectedly, it turned out that in the case of the PVA cryotropic gel formation in DMSO medium, the URE and GHC additives caused the opposite effects to those observed in water, i.e., the formation of the PVA cryogels (PVACGs) was strengthened rather than inhibited. Our studies of this phenomenon showed that such “kosmotropic-like” effects were more pronounced for the PVACGs that were formed in DMSO in the presence of URE additives, with the effects being concentration-dependent. The additives also caused significant changes in the macroporous morphology of the cryogels; the commonly observed trend was a decrease in the structural regularity of the additive-containing samples compared to the additive-free gel sample. The viscosity measurements revealed consistent changes in the intrinsic viscosity, Huggins constant, and the excess activation heat of the viscosity caused by the additives. The results obtained evidently point to the urea-induced decrease in the solvation ability of DMSO with respect to PVA. As a result, this effect can be the key factor that is responsible for strengthening the structure formation upon the freeze–thaw gelation of this polymer in DMSO additionally containing additives such as urea, which is capable of competing with PVA for the solvent.

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“…The temperature/time regimes of the cryogenic processing used for the preparation of both the non-filled and composite PVA cryogels (samples 1a; 2a; 3a and samples 1b,c; 2b,c; 3b,c, respectively) were identical, namely, freezing at −20 °C for 12 h followed by thawing of the frozen samples by their heating at the rate of 0.03 °C/min ( Section 3.2.2 ). These conditions are close to optimal and commonly employed for the preparation of both filler-free and filled PVA cryogels [ 34 , 35 , 36 , 37 , 73 , 74 , 75 ]. When using a similar technique, it is possible to form such gel materials of diverse shapes, e.g., rods, cubes, plates, discs, granules, etc., [ 3 , 4 ].…”

Section: Resultsmentioning

confidence: 94%

Cryo-Structuring of Polymeric Systems. Poly(Vinyl Alcohol)-Based Cryogels Loaded with the Poly(3-hydroxybutyrate) Microbeads and the Evaluation of Such Composites as the Delivery Vehicles for Simvastatin

et al. 2022

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Highly porous composite poly(vinyl alcohol) (PVA) cryogels loaded with the poly(3-hydroxybutyrate) (PHB) microbeads containing the drug, simvastatin (SVN), were prepared via cryogenic processing (freezing—storing frozen—defrosting) of the beads’ suspensions in aqueous PVA solution. The rigidity of the resultant composite cryogels increased with increasing the filler content. Optical microscopy of the thin section of such gel matrices revealed macro-porous morphology of both continuous (PVA cryogels) and discrete (PHB-microbeads) phases. Kinetic studies of the SVN release from the drug-loaded microbeads, the non-filled PVA cryogel and the composite material showed that the cryogel-based composite system could potentially serve as a candidate for the long-term therapeutic system for controlled drug delivery. Such PHB-microbeads-containing PVA-cryogel-based composite drug delivery carriers were unknown earlier; their preparation and studies have been performed for the first time.

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Influence of processing parameters on the macroscopic mechanical behavior of PVA hydrogels

Cited by 20 publications

References 18 publications

Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

Film Dressings Based on Hydrogels: Simultaneous and Sustained-Release of Bioactive Compounds with Wound Healing Properties

Cryostructuring of Polymeric Systems. 49. Unexpected “Kosmotropic-Like” Impact of Organic Chaotropes on Freeze–Thaw-Induced Gelation of PVA in DMSO

Cryo-Structuring of Polymeric Systems. Poly(Vinyl Alcohol)-Based Cryogels Loaded with the Poly(3-hydroxybutyrate) Microbeads and the Evaluation of Such Composites as the Delivery Vehicles for Simvastatin

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