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Cited by 50 publications
(10 citation statements)
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“…This clinical observation is supported by experimental work in organ (39) and tissue (12) culture showing increased cell damage at low pH, and by animal experiments which have demonstrated an increased brain uptake of bilirubin in acidemic guinea pigs (16) and increased CSF bilirubin in acidemic rabbits (38). A decreased pH has also been shown to enhance the uptake of bilirubin by erythrocytes and mitochondria when incubated in media containing albumin (3,32).…”
Section: Printed In Usamentioning
confidence: 53%
See 1 more Smart Citation
“…This clinical observation is supported by experimental work in organ (39) and tissue (12) culture showing increased cell damage at low pH, and by animal experiments which have demonstrated an increased brain uptake of bilirubin in acidemic guinea pigs (16) and increased CSF bilirubin in acidemic rabbits (38). A decreased pH has also been shown to enhance the uptake of bilirubin by erythrocytes and mitochondria when incubated in media containing albumin (3,32).…”
Section: Printed In Usamentioning
confidence: 53%
“…The increased toxicity of bilirubin at low pH has been attributed to a decrease in albumin binding of bilirubin (3,11,28,32,33). However, supporting experimental evidence for decreased binding within the physiologic pH range is conflicting, and the possibility exists that cells may be more sensitive to bilirubin at low pH (12,16,39,45).…”
Section: Printed In Usamentioning
confidence: 99%
“…All studies demonstrated increased tissue binding of bilirubin at low pH, with or without the presence of albumin. Proposed mechanisms for increased uptake vary from altered albumin binding (13,14) to precipitation of bilirubin acid in membranes (6,7). The importance of the bilirubin acid salt in tissue uptake has not been previously recognized.…”
Section: Discussionmentioning
confidence: 99%
“…The recognition that pH affects each of these reactions differently further complicates this model. Within the physiologic pH range, bilirubin binding to albumin is essentially independent of hydrogen ion concentration (1 1, 12), but bilirubin binding to tissue increases at lower pH (8,(12)(13)(14). Inasmuch as pH influences binding to a variety of cell membranes, mitochondria, phospholipid liposomes, and even sephadex (1 5), the explanation for the effect is more likely to be found in the chemistry of bilirubin than in pH-induced alterations of the membranes.…”
mentioning
confidence: 95%
“…The further decrease in bilirubin concentration in the media when cells were present can be explained on the basis of a decrease in pH, oxidation, uptake by the cells as evident by the yellow staining when they were harvested, or as in the case of the higher molar ratio of bilirubin to albumin, precipitation and aggregation of the pigment to the walls of the container. The influence of a decrease in pH on tissue binding or toxicity of bilirubin was observed in red blood cells (1 5), mitochondria ( 16), and cerebellar culture cells (2), while tissue culture cells such as L-929 cells (5) seemed less susceptible to bilirubin toxicity when the pH was lowered from 7.4 to 7.0. It is doubtful whether a decrease from pH 7.5 to pH 7.3 in 24 h was a contributing factor in cell viability in the present experiments.…”
Section: Discussionmentioning
confidence: 99%