Influence of pH, Humic Acids, and Salts on the Dissipation of Amoxicillin and Azithromycin Under Simulated Sunlight

Rodríguez-López, Lucía; Santás-Miguel, Vanesa; Núñez‐Delgado, Avelino; Álvarez‐Rodríguez, Esperanza; Pérez‐Rodríguez, Paula; Arias‐Estévez, Manuel

doi:10.3389/sjss.2022.10438

Cited by 13 publications

(4 citation statements)

References 61 publications

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“…This process will depend on multiple factors of the antibiotics, such as their log K OW , pK a , ionisation state, binding properties and buffering conditions (Tran et al, 2018;Jodeh et al, 2022). The pH of the medium will play a fundamental role in the different process in soil like degradation (Rodríguez-López et al, 2022a) or mainly in adsorption and will clearly influence its fate since antibiotics tend to behave differently depending on the pH, as they are amphoteric molecules, which can behave as anions, zwitterions, or cations. The pH not only influences the solubility and behaviour of the compounds but also the characteristics of the sorbent and can change the interactions between the contaminant and the sorbent (Anuar et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Sorption of Antibiotics in Agricultural Soils as a Function of pH

Rodríguez-López,

Santás-Miguel,

Cela-Dablanca

et al. 2024

Span. J. Soil Sci.

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This study aims to understand the adsorption/desorption process in six agricultural soils of two antibiotics, Ciprofloxacin (CIP) and Trimethoprim (TRI), widely used today and the influence of pH on this process. Antibiotics can reach the soil through the application of sludge and effluents from wastewater treatment plants and are directly influenced by changes in pH, once in the soil. Therefore, this study with batch experiments allows us to know the adsorption process in a pH range between 2 and 12, in six soils with different organic carbon content, between 1% and 7.7%. The results obtained show that the adsorption of CIP has its maximum at pH between 5 and 7; above and below this range, the adsorption decreases. The soils with the highest organic carbon content (between 4.4% and 7.7%) are those with the highest adsorption. The values for each forms in which the CIP molecule is found are: for KdCIP+, between 0.887 and 8.289 L kg−1; for KdCIP−, between 0.670 and 5.440 L kg−1, while for KdCIP0, the values do not differ from 0, except soils 1 and 3, whose values are 0.206 and 0.615 L kg−1, respectively. Regarding TRI, the maximum adsorption takes place at acidic pHs, below 6 for all soils. Above these values, desorption decreases. The Kd values for each of the species vary between 0.085 and 0.218 L kg−1 for KdTRI+, between 0.011 and 0.056 L kg−1 for KdTRI0, and between 0.092 and 0.189 L kg−1 for KdTRI−. For both antibiotics, the highest adsorption was achieved in the soil with the highest organic carbon content (7.7%). Comparing both antibiotics, we see that CIP presents the highest adsorption, and in the case of desorption, for CIP, it varies between 3.7% and 75.8%, with the maximum desorption at basic pHs. In the case of TRI, desorption is higher, varying between 9.4% and 99.1%, with the maximum around neutrality, except for two soils, whose maximums are at pH of 4.3 and 9.5. These results should be taken into account, as once they reach the soil, pH will be a determining factor in their behaviour and fate.

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Section: Introductionmentioning

confidence: 99%

Sorption of Antibiotics in Agricultural Soils as a Function of pH

Rodríguez-López,

Santás-Miguel,

Cela-Dablanca

et al. 2024

Span. J. Soil Sci.

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“…In this regard, there are several studies that have evaluated the toxicity of heavy metals in soil microbial communities (Hattori, 1992;Giller et al, 1998;Giller et al, 2009;Abdu et al, 2017). On the other hand, there are also previous studies focused on studying the effects of antibiotics on soil microorganisms (Thiele-Bruhn, 2005;Toth et al, 2011;Caban et al, 2018;Urra et al, 2019), however, there are few studies that focus on the study of tetracyclines in soil bacterial communities, such as Santás-Miguel et al (2020a); Santás-Miguel et al, 2020c;Santás-Miguel et al, 2020d), or on the temporal evolution of various antibiotics affected by environmental conditions, such as Rodríguez-López et al (2022). On the other hand, several works evaluated the cotolerance to antibiotics of soil bacterial communities, at the functional and genetic level, in soils contaminated with heavy metals (Bååth, 1989;Berg et al, 2010;Oyetibo et al, 2010;Ji et al, 2012;Dickinson et al, 2019;Santás-Miguel et al, 2020b;Santás-Miguel et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Soil Bacterial Community Tolerance to Three Tetracycline Antibiotics Induced by Ni and Zn

et al. 2023

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A laboratory work has been carried out to determine the tolerance of soil bacterial communities to Ni and Zn and co-tolerance to tetracycline antibiotics (chlortetracycline (CTC), oxytetracycline (OTC) and tetracycline (TC)) in soils individually spiked with five different concentrations of Ni or Zn (1,000, 750, 500, 250, and 125 mg kg−1), and an uncontaminated (0 mg kg−1) control soil. The PICT parameter (pollution-induced community tolerance) was estimated for the bacterial community using the tritium (3H)-labeled leucine incorporation technique, and the values corresponding to log IC50 were used as toxicity index. The mean log IC50 values observed in the uncontaminated soil samples indicate that Zn (with log IC50 = −2.83) was more toxic than Ni (log IC50 = −2.73). In addition, for the soil with the lowest carbon content (C = 1.9%), Ni-contaminated samples showed increased tolerance when the Ni concentrations added were ≥500 mg kg−1, while for the soils with higher carbon content (between 5.3% and 10.9%) tolerance increased when Ni concentrations added were ≥1,000 mg kg−1. Regarding the soils contaminated with Zn, tolerance increased in all the soils studied when the Zn concentrations added were ≥125 mg kg−1, regardless of the soil carbon content. The co-tolerance increases obtained after exposure of the bacterial suspension to TC, OTC and CTC showed an identical behavior within these tetracycline antibiotics. However, it was dependent on the heavy metal tested (Ni or Zn). In the case of soils 1 (C = 1.1%) and 2 (C = 5.3%), the soil bacterial communities showed increases in co-tolerance to TC, OTC and CTC for Ni concentrations added of ≥125 mg kg−1, while for soil 3 (with C = 10.9%) co-tolerance took place when Ni was added at ≥1,000 mg kg−1. However, in soils contaminated with Zn, increases in co-tolerance to CTC, OTC and TC occurred at Zn concentrations added of ≥125 mg kg−1 for the 3 soils tested. These results can be considered relevant when anticipating possible environmental repercussions related to the simultaneous presence of various types of pollutants, specifically certain heavy metals and antibiotics.

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“…Several studies have detected antibiotic uptake in crops like carrot and barley (Eggen et al, 2011), corn, green onion and cabbage (Kumar et al, 2005), lettuce and radish (Bassil et al, 2013) and grass, corn and wheat (Conde-Cid et al, 2018). It has been shown that different antibiotics may also impact on the soil microbial biomass (Santás-Miguel et al, 2020), and that their degradation in the soil environment is affected by variables such as soil pH, humic acids and salts (Rodríguez-López et al, 2022), which could substantially change after sludge spreading.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Nine Antibiotics in Different Kinds of Sewage Sludge, Soils, Corn and Grapes After Sludge Spreading

Barreiro¹,

Cela-Dablanca²,

Nebot³

et al. 2022

Span. J. Soil Sci.

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The huge worldwide use of antibiotics triggers the accumulation of these substances in sludge from wastewater treatment plants (WWTP) and the possible contamination of soils amended with it, as well as of crops growing in these soils. In this work we analyzed the presence of the antibiotics amoxicillin (AMO), cefuroxime (CEF), ciprofloxacin (CIP), clarithromycin (CLA), levofloxacin (LEV), lincomycin (LIN), norfloxacin (NOR), sulfadiazine (SUL), and trimethoprim (TRI), in sludge from different WWTPs in Galicia (NW Spain), as well as in sludge technically treated by waste-managers, in soils where treated sludge was applied, and in crops (corn and vineyard) growing in the amended areas. The antibiotics were quantified by means of high resolution HPLC-mass-chromatography. The results indicate that almost all the sludge samples contained antibiotics, being ciprofloxacin and levofloxacin the most abundant reaching maximum values of 623 and 893 ng/g, respectively. The sludge treatment significantly reduced the number and the concentrations of antibiotics. In 12% of the soil samples where sludge was applied, some antibiotics were detected, but always in small concentrations. Regarding the crops, no antibiotic was detected in the roots, stalk, leaves and grain of corn, neither in grapes sampled in vineyards. It can be concluded that the treatments currently applied in the WWTPs under study are not totally effective in removing antibiotics from the sludge, although the findings of this research suggest that the additional specific treatment of the sludge derived from these WWTPs is effective in reducing the risk of environmental pollution due to a variety of antibiotics, and specifically in the case of soils amended with these organic materials and crops growing on it.

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Influence of pH, Humic Acids, and Salts on the Dissipation of Amoxicillin and Azithromycin Under Simulated Sunlight

Cited by 13 publications

References 61 publications

Sorption of Antibiotics in Agricultural Soils as a Function of pH

Sorption of Antibiotics in Agricultural Soils as a Function of pH

Soil Bacterial Community Tolerance to Three Tetracycline Antibiotics Induced by Ni and Zn

Occurrence of Nine Antibiotics in Different Kinds of Sewage Sludge, Soils, Corn and Grapes After Sludge Spreading

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