volume 67, issue 1, P110-118 1986
DOI: 10.1182/blood.v67.1.110.bloodjournal671110
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GB Nash,
CS Johnson,
HJ Meiselman

Abstract: Although the rheological behavior of sickle cell suspensions and of hemoglobin S solutions is known to be strongly dependent on oxygen tension (PO2), little data exist concerning the influence of PO2 on the viscoelasticity of individual HbSS RBC. We have used micropipette aspiration techniques to test the deformation response of both HbSS and control HbAA RBC over a wide range of PO2 at 23 degrees C. Sickled, spiculed HbSS cells were present for PO2 approximately less than 35 mm Hg; for a number of these cells…

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