Influence of oral polyunsaturated and saturated phospholipid treatment on the lipid composition and fatty acid profile of chimpanzee lipoproteins

Rosseneu, Maryvonne; Declercq, B; Vandamme, Dries; Vercaemst, R.; Soetewey, F.; Peeters, H.; Blaton, V.

doi:10.1016/0021-9150(79)90079-0

Cited by 52 publications

(10 citation statements)

References 9 publications

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“…a Significance from SO-fed rats by Students't test at p<0.05. pigs (2), monkeys (3,4) and humans (5) that soybean phospholipid (SP) decreases the concentration of serum cholesterol. The amount of the SP (10%) given was comparable to quantities given in other experiments (4,5,7).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary polyunsaturated phospholipid on the chemical composition of serum lipoproteins in rat.

Imaizumi

Murata

Sugano

1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe effect of soybean phospholipid (SP), given at the rate of 100g/kg diet for 2-3 weeks, on the chemical composition of serum lipoprotein in rats was examined. Soybean oil (SO) containing almost comparable amounts of linoleic acid was used as a control diet . SP significantly decreased the concentration of serum cholesterol and apo lipoprotein A-I (apo A-I) and increased apolipoprotein B (apo B) . There was no significant change in the concentration of serum apolipoprotein E (apo E) and the other lipids. The reduction of cholesterol levels in all the lipoprotein fractions was observed. The reduction of the serum apo A-I was brought about by the addition of SP at the level of 1% while that of the cholesterol at the level of 4%. The subunit composition of apo A-I, but not apolipoprotein C, in high density lipoprotein (HDL) was also altered by SP. The high molecular weight of apo B was responsible for the increment of apoproteins in the low density lipoprotein (LDL) . The triglyceride, but not the cholesterol ester, also increased in LDL . There was no significant difference between the groups in the fatty acid compositions of serum triglyceride and phospholipid. In the liver, SP significantly increased the concentration of cholesterol ester and decreased triglyceride. These results are discussed in the context of the role of the lipoprotein and apoprotein in the regulation of serum cholesterol concentration.

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Section: Discussionmentioning

confidence: 99%

Effect of dietary polyunsaturated phospholipid on the chemical composition of serum lipoproteins in rat.

Imaizumi

Murata

Sugano

1982

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Also PUFAs rise LDLR activity and affinity of LDL with LDL receptor, elevate the ability of LDL uptake in the receptor-dependent manner, and accelerate the clearance speed of cholesterol [28]. Meanwhile PUFAs increase levels of cholesteryl ester and lysophosphatidylcholine which induced changes of structure of HDL particle tending towards fluidity and density as favorable carrier during reverse cholesterol transport [29]. …”

Section: Discussionmentioning

confidence: 99%

Effects of Extract from Cole Pollen on Lipid Metabolism in Experimental Hyperlipidemic Rats

Geng

Zhang

et al. 2014

The Scientific World Journal

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In order to evaluate the effects of extract by SCE (supercritical carbon dioxide extraction) from cole pollen on lipid metabolism in hyperlipidemic rats, the experimental hyperlipidemic rats were established by providing with high fat diets, and randomized into six groups. After four weeks of perfusion diets into stomach, the rats were executed, and lipid levels of serum and hepatic tissue were detected. The serum levels of TC and TG were significantly lower in the pollen extract groups and MC group than in HFC group. Hepatic TC levels were decreased in rats fed pollen extract and lovastatin compared with HFC group. A higher concentration of HDL-C and apoAI in hepatic tissue was measured after intake of the pollen extract compared to the HFC group (P < 0.05). LCAT activity in serum of pollen extract groups was significantly higher than that in HFC group, and also HMG-CoA reductase showed decreasing tendency in pollen extract groups. The contents of DHA in pollen extract groups were found higher than those in HFC group. Cole pollen extract enriched in alpha-linolenic acid is likely to be a novel source of ALA which is probably responsible for favorable lipid changes through promoting transportation, excretion, and metabolism of cholesterol in hepatic tissue and serum.

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“…Several mechanisms might be responsible for this effect. There could be an increase in the activities of cholesteryl ester hydrolase in the arterial wall (3,4); there might be an activation of triglyceride lipase (5); or there could be changes in the metabolism of high density lipoproteins (HDL) (6). Further, high doses of lecithin in the diet might interfere with absorption of cholesterol, or they might alter the metabolism of triglycerides or low density lipoproteins (LDL).…”

Section: Introductionmentioning

confidence: 98%

Dietary Lecithin: Metabolism, Fate, and Effects on Metabolism of Lipids and Lipoproteins

Grundy

1987

Drugs Affecting Lipid Metabolism

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Influence of oral polyunsaturated and saturated phospholipid treatment on the lipid composition and fatty acid profile of chimpanzee lipoproteins

Cited by 52 publications

References 9 publications

Effect of dietary polyunsaturated phospholipid on the chemical composition of serum lipoproteins in rat.

Effect of dietary polyunsaturated phospholipid on the chemical composition of serum lipoproteins in rat.

Effects of Extract from Cole Pollen on Lipid Metabolism in Experimental Hyperlipidemic Rats

Dietary Lecithin: Metabolism, Fate, and Effects on Metabolism of Lipids and Lipoproteins

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