2017
DOI: 10.18632/aging.101210
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Abstract: Omega-3 polyunsaturated fatty acids (n3-PUFA) are recognized for their anti-inflammatory effects and may be beneficial in the context of sarcopenia. We determined the influence of n3-PUFA on muscle mitochondrial physiology and protein metabolism in older adults. Twelve young (18-35 years) and older (65-85 years) men and women were studied at baseline. Older adults were studied again following n3-PUFA supplementation (3.9g/day, 16 weeks). Muscle biopsies were used to evaluate respiratory capacity (high resoluti… Show more

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Cited by 91 publications
(110 citation statements)
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References 68 publications
(106 reference statements)
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“…Recently, the effects of n-3 PUFA supplementation were tested in skeletal muscle mitochondria from older men. Sixteen weeks of n-3 PUFA supplementation was not able to change maximal mitochondrial oxygen consumption, however, there was a decrease in mitochondrial ROS emission in the presence of several substrates [37]. These findings raise the positive biological effects of n-3 PUFA on mitochondrial function and redox state, which can lower inflammation and improve muscle function in elderly.…”
Section: Nutritionmentioning
confidence: 76%
“…Recently, the effects of n-3 PUFA supplementation were tested in skeletal muscle mitochondria from older men. Sixteen weeks of n-3 PUFA supplementation was not able to change maximal mitochondrial oxygen consumption, however, there was a decrease in mitochondrial ROS emission in the presence of several substrates [37]. These findings raise the positive biological effects of n-3 PUFA on mitochondrial function and redox state, which can lower inflammation and improve muscle function in elderly.…”
Section: Nutritionmentioning
confidence: 76%
“…However, supplements with ω -3 eicosapentanoic acid and docosahexaenoic acid, but not ω -6, are reported to improve skeletal muscle damage, stiffness and regeneration [48][49][50] . In vivo studies in elderly human probands and insulin-resistant non-diabetic patients, ω -3 PUFA supplementation had no effect on mitochondrial function 48,51 but improved mitochondrial ADP kinetics and insulin sensitivity in young, healthy adults 52 . Pre-treatment with ω -3 fatty acid eicosapentanoic acid but not docosahexaenoic acid stimulates fatty acid ß-oxidation and glucose transport in human myotubes 53 .…”
Section: Discussionmentioning
confidence: 91%
“…Omega‐3, polyunsaturated fatty acids ( PUFA , abundant in fish oil, present anti?thrombotic, antiatherogenic and anti‐inflammatory functions . These fatty acids are PPAR ligands and increase PGC‐1α, TFAM, and cyt C oxidase expression, membrane potential and ATP levels in mitochondria .…”
Section: Nutritional Strategies Targeting Mitochondrial Dysfunction Imentioning
confidence: 99%
“…Taneda et al showed that rat tubular epithelial cells treated in vitro and in vivo with eicosapentaenoic acid (EPA) presented decreased mitochondrial apoptosis by preventing cyt C release to the cytosol and could reduce caspase‐9 activation, a marker of mitochondrial apoptosis. Lalia et al studied the effects of high dose (3.9 g/day) n3‐PUFA for 4 months on the mitochondria from vastus lateralis muscle biopsies in older adults. There was no significant change in muscle mitochondrial respiration rates, but the results pointed towards a reduction in ROS production.…”
Section: Nutritional Strategies Targeting Mitochondrial Dysfunction Imentioning
confidence: 99%
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